Worker Protection Standards (WPS) were established to protect pesticide handlers and agricultural workers. This federal EPA regulation requires that employees are informed about pesticide use and protection practices. WPS requires pesticide safety training for workers and handlers, display of safety posters, and access to labeling and other specific information at a central location. Further protection is ensured by excluding workers from areas being treated with a pesticide, REI (Restricted-Entry Intervals) following a pesticide application, and proper use of PPE (Personal Protective Equipment). REI's and protective clothing requirements are listed on the pesticide label.

Some herbicide products are classified as Restricted Use Pesticides because they have a higher potential for affecting the environment, humans, or animals. Herbicides currently classified as Restricted Use appear below. Pesticide certification is required to purchase and use these products.

When Restricted Use Pesticides are used, accurate records of the application are required by federal law. An applicator must make a written record within 30 days after the application. Records to keep include product name and EPA registration number, total amount applied, location, crop or site of application, size of treated area, name and certification number of applicator or supervisor, and date of application.