Professor of
Nutrition and Toxicology; Ph.D. in Nutrition, Iowa State, 1982.
Dr. Hennig’s
primary appointment is in the College
of Agriculture. He also has academic appointments with the
Center of Nutritional
Sciences, Graduate
Center for Toxicology and the
Center of Membrane Sciences, and he is a member of the Gill
Heart Institute.
Dr. Hennig is the current
Director of the University of Kentucky Superfund Basic Research Program
(http://www.uky.edu/Research/Superfund/)
or http://www-apps.niehs.nih.gov/sbrp/index.cfm
Dr. Hennig is the Editor-in-Chief
of the Journal of Nutritional Biochemistry (http://www.elsevier.com/locate/jnutbio)
Dr. Hennig also
serves on the Editorial Boards for the Journal of the American College
of Nutrition, and Nutrition Research. He is a Fellow of the
American College of Nutrition, and Fellow of the Council on Arteriosclerosis,
American Heart Association. Dr. Hennig also is a Council Member of the
Cardiovascular Hypertension Section, American College of Nutrition.
NATIONAL
AWARDS
| • |
Fulbright
Recipient, 2008; Universidad de Antioquia, Medellín, Colombia |
| • |
Helen
LeBaron Hilton Award for Outstanding Leadership and Distinguished
Achievement; Iowa State University, 2006 |
| • |
Grace
A. Goldsmith Award for Significant Current Achievements in the Field
of Nutrition, 1995 |
| • |
Borden
Award for Significant Research in Nutrition, 1993 |
| • |
Clintec
Award for Excellence in the Science of Nutrition, 1993 |
RESEARCH
EMPHASIS
Dr. Hennig’s
research emphasis involves the utilization of tissue culture model systems
in the study of nutrition and atherosclerosis, with emphasis in the
role of nutrients on biochemical and molecular mechanisms of vascular
endothelial cell function, injury and protection. His research has focused
on the injurious effects of individual fats (e.g., fatty acids, cholesterol
and their oxidation derivatives) to vascular endothelial cells and protection
against such injury by certain vitamins and minerals (e.g., vitamin
E and zinc). Because the nutritional environment of the vascular endothelium
can influence cytokine-mediated endothelial activation or dysfunction,
vascular effects of inflammatory cytokines also are being studied. In
addition, Dr. Hennig is studying molecular mechanisms of nutrient interactions
with the cytotoxic effects of specific environmental contaminants, such
as persistent organic pollutants, in relation to endothelial cell activation
and the pathology of atherosclerosis. Results from these studies may
suggest novel therapeutic interventions by further understanding "endothelial
cell nutrition" as a key variable in the etiology of diseases such
as atherosclerosis.
RECENT
PUBLICATIONS (OUT OF OVER 170)
For a complete list: PubMed
Lei W, Lim EJ,
Toborek M, Hennig B. The role of fatty acids an d caveolin-1
in TNF-alpha-induced endothelial cell activation. Metabolism (in press)
Zheng YY, Lim EJ, Wang L, Smart EJ, Toborek M, Hennig B.
Role of caveolin-1 in EGCG-mediated protection against linoleic acid-induced
endothelial cell activation. J Nutr Biochem (in press)
András IE, Rha GB, Huang W, Eum SY, Couraud PO, Hennig
B, Toborek M. Simvastatin protects against amyloid beta and
HIV-1 Tat-induced promoter activities of inflammatory genes in brain
endothelial cells. Mol Pharmacol (in press)
Venkatachalam K, Arzuaga X, Chopra N, Gavalas VG, Xu J, Bhattacharyya
D, Hennig B, Bachas LG. Reductive dechlorination of
3,3’,4,4’-tetrachloro biphenyl (PCB) using palladium or
palladium/iron nanoparticles and assessment of the reduction in toxic
potency in vascular endothelial cells. J Hazard Mater (in press)
Lee, YW, Hennig B, Yao J, Toborek M. Methamphetamine
induces AP-1 and NF-kappaB binding and transactivation in human brain
endothelial cells. J. Neurosci. Res. (in press)
Choi W, Eum SY, Lee YW, Hennig B, Robertson LW, Toborek
M. PCB 104-induced proinflammatory reactions in human vascular endothelial
cells: relationship to cancer metastasis and atherogenesis. Toxicol.
Sci. (in press)
András IE, Pu H, Tian J, Deli MA, Nath A, Hennig, B,
Toborek M. Signaling mechanisms of HIV-1 Tat-induced alterations of
claudin-5 expression in brain endothelial cells. Journal of Cerebral
Blood Flow & Metabolism (J Cereb Blood Flow Metab). (in press)
Pu H, Tian J, András IE, Hayashi K, Flora G, Hennig B,
Toborek M. HIV-1 TAT protein-induced alterations of ZO-1 expression
are mediated by redox-regulated ERK1/2 activation. J Cereb Blood Flow
Metab (in press)
Majkova Z, Oesterling
E, Toborek M, and Hennig B. Impact of nutrition on
PCB toxicity. Environ Toxicol Pharmacol, 25: 192-196, 2008.
Shen H, Arzuaga X, Toborek M, and Hennig B. Zinc nutritional
status modulates expression of AhR-responsive P450 enzymes in vascular
endothelial cells. Environ Toxicol Pharmacol, 25: 197-201, 2008.
Eum SY, Andras IE, Couraud PO, Hennig B, Toborek M.
PCBs and tight junction expression. Environ Toxicol Pharmacol, 25: 234-240,
2008.
Sipka S, Eum SY, Son KW, Xu S, Gavalas VG, Hennig B,
Toborek M. Oral administration of PCBs induces proinflammatory and prometastatic
responses. Environ Toxicol Pharmacol, 25: 251-259, 2008.
Wang L, Reiterer G, Toborek M, Hennig B.Changing ratios
of omega-6 to omega-3 fatty acids can differentially modulate polychlorinated
biphenyl toxicity in endothelial cells.Chem Biol Interact, 172:27-38,
2008.
Pu H, Hayashi K, Andras IE, Eum SY, Hennig B, Toborek
M. Limited role of COX-2 in HIV Tat-induced alterations of tight junction
protein expression and discruption of the blood-brain barrier. Brain
Res, 1184: 333-344, 2007.
Lim EJ, Smart E, Toborek M, Hennig B. The role of caveolin-1
in PCB77-induced eNOS phosphorylation in human-derived endothelial cells.
Am J Physiol Heart Circ Physiol, 293: H3340-3347, 2007.
Arzuaga A, Reiterer G, Majkova Z, Kilgore MW, Toborek M, and Hennig
B. Activation of PPARalpha reduces PCB-induced endothelial
activation:possible interactions in inflammation and atherosclerosis.
Cardiovasc Toxicol, 7:264-272,2007.
Shen H, MacDonald R, Bruemmer D, Stromberg A, Daugherty A, Li X, Toboreck
M, and Hennig B. Zinc deficiency alters lipid metabolism
in LDL-receptor-deficient mice treated with rosiglitazone J Nutr, 137:
2339-2345, 2007.
András IE, Deli M, Veszelka S, Hayashi K, Hennig B,
Toborek M. The NMDA and AMPA/KA receptors are involved in glutamate-induced
alterations of occludin expression and phosphorylation in brain endothelial
cells. J Cereb Blood Flow Metab, 27:1431-1443, 2007.
Umannova L, Zatloukalova J, Machala M, Krcmar P, Majkova Z, Hennig
B, Kozubik A, Vondracek J.
Tumor necrosis factor-alpha modulates effects of aryl hydrocarbon receptor
ligands on cell proliferation and expression of cytochrome P450 enzymes
in rat liver "stem-like" cells. Toxicol Sci, 99:79-89, 2007.
Hennig B, Ettinger AS, Jandacek RJ, Koo S, McClain
C, Seifried H, Silverstone A, Watkins B, Suk WA. Using nutrition for
intervention and prevention against environmental chemical toxicity
and associated diseases. Environ Health Perspect, 115:493-5, 2007.
Hennig B, Oesterling E, Toborek M. Environmental toxicity,
nutrition, and gene interactions in the development of atherosclerosis.
Nutr Metab Cardiovasc Dis, 17: 162-169, 2007.
Hennig
B, Lei W, Arzuaga X, Das Ghosh D, Saraswathi V, Toborek M.
Linoleic acid induces proinflammatory events in vascular endothelial
cells via activation of the PI3K/Akt and ERK1/2 signaling. J Nutr Biochem,
17: 766-772, 2006.
Eum SY, Lee
YW, Hennig B, Toborek M. Interplay between epidermal
growth factor receptor and Janus kinase 3 regulates polychlorinated
biphenyl-induced metalloproteinase-3 expression and transendothelial
migration of tumor cells. Mol Cancer Res, 4: 361-370, 2006.
Eum SY, Rha
GB, Hennig B, Toborek M. c-Src is the primary signaling
mediator of polychlorinated biphenyl-induced interleukin-8 expression
in a human microvascular endothelial cell line. Toxicol Sci, 92: 311-320,
2006.
Hayashi K,
Pu H, András IE, Eum SY, Yamauchi A, Hennig B,
Toborek M. HIV-TAT protein upregulates expression of multidrug resistance
protein 1 in the blood-brain barrier. Journal of Cerebral Blood Flow
& Metabolism (JCBFM), 26: 1052-1065, 2006.
Flora G, Pu
H, Hennig B, Toborek M. Cyclooxygenase-2 is involved
in HIV-1 Tat-induced inflammatory responses in the brain. NeuroMolecular
Med, 8: 337-351, 2006.
Reiterer G,
Toborek M, Hennig B. Zinc and cell signaling during
inflammation: implications in atherosclerosis. Current Nutrition &
Food Science, 2: 23-28, 2006.
Hennig,
B., M. Toborek, P. Ramadass, G. Ludewig, L.W. Robertson. Polychlorinated
Biphenyls, Oxidative Stress and Diet. pp. 93-128. In: Reviews in Food
and Nutrition Toxicity; edited by Preedy and Watson; CRC Press, Boca
Raton, FL. 2005.
Flora, G., H.
Pu, Y.W. Lee, R. Ravikumar, A. Nath, B. Hennig and
M. Toborek. Proinflammatory synergism of ethanol and HIV-1 Tat protein
in brain tissue. Experimental Neurology, 191: 2-12. 2005.
Hansen, L.,
M. Machala, L. Fischer, M. James, B. Hennig, H. Glauert,
J.F. Narbonne, L. van Bree, T. Schultz, P. Grevatt, W. Suk, I. Holoubek,
and L. Robertson. Research needs identified at the Second PCB Workshop
in Brno, Czech Republic, May 7-11, 2002. Toxicological and Environmental
Chemistry, 87: 261-265. 2005.
Hayashi, K.,
H. Pu, J. Tian, I.E. Andras, Y.W. Lee, B. Hennig and
M. Toborek. HIV-Tat protein induces P-glycoprotein expression in brain
microvascular endothelial cells. Journal of Neurochemistry 93:1231-1241.
2005.
Hennig,
B., G. Reiterer, Z. Majkova, E. Oesterling, P. Meerarani and
M. Toborek. Modification of environmental toxicity by nutrients: implications
in atherosclerosis. Cardiovascular Toxicology 5(2):153-60. 2005.
Hennig, B.,
G. Reiterer, M. Toborek, S.V. Matveev, A. Daugherty, E. Smart and L.
Robertson. Dietary fat interacts with PCBs to induce changes in lipid
metabolism in LDL receptor deficient mice. Environ.mental Health Perspectives
113: 83-87. 2005.
Reiterer, G., R. MacDonald,
J.D. Browning, J. Marrow, S.V. Matveev, A. Daugherty, E. Smart, M. Toborek
and B. Hennig. Zinc deficiency induces atherogenic
events in LDL-R-deficient mice. Journal of Nutrition, 135:2114-2118.
2005.
Toborek, M., Y.W. Lee, G.
Flora, H. Pu, I.E. Andras, E. Wylegala, B. Hennig and
A. Nath. Mechanisms of blood-brain barrier disruption in HIV-1 infection.
Cellular and Molecular Neurobiology 25: 181-199. 2005.
Lee, Y.W., S.Y.
Eum, K.C. Chen, B. Hennig, and M. Toborek. Gene expression
profile of interleukin-4-treated human vacular endothelial cells. Molecular
Medicine 10(1-6):19-27. 2004.
Reiterer G,
Toborek M, Meerarani P, Hennig B. Peroxisome proliferator
activated receptors alpha and gamma require zinc for their anti-inflammatory
properties in porcine vascular endothelial cells. J. Nutr. 134:1711-5,
2004
Reiterer G,
Toborek M, Hennig B. Quercetin protects against linoleic
acid-induced endothelial cell dysfunction without PPAR-gamma activation.
J. Nutr., 134: 771-775, 2004.
Hennig
B, Toborek M, Bachas LG, Suk WA. Emerging issues: Nutritional
awareness in environmental toxicology. J. Nutr. Biochem., 15: 194-195,
2004.
Saraswathi
V, Wu G, Toborek M, Hennig B. Linoleic acid-induced
endothelial activation: role of calcium and peroxynitrite signaling.
J. Lipid Res., 45: 794-804, 2004.
Ravikumar R,
Flora G, Geddes JW, Hennig B, Toborek M. Nicotine attenuates
oxidative stress, activation of redox-regulated transcription factors
and induction of proinflammatory genes in compressive spinal cord trauma.
Brain Res Mol Brain Res., 124:188-98, 2004.
Eum SY, Lee
YW, Hennig B, Toborek M. VEGF regulates PCB 104 mediated
stimulation of permeability and transmigration of breast cancer cells
in human microvascular endothelial cells. Exp. Cell Res., 294: 231-44,
2004.
Chalimoniuk
M, King-Pospisil K, Pedersen WA, Malecki A, Wylegala E, Mattson MP,
Hennig B, Toborek M. Arachidonic acid increases choline
acetyltransferase activity in spinal cord neurons through a protein
kinase C-mediated mechanism. J. Neurchem., 90: 629-36, 2004.
Lee, Y.W., Hennig
B., Toborek M.. Redox-regulated mechanisms of interleukin-4-induced
MCP-1 expression in human vascular endothelial cells. Am. J. Physiol.,
284: H185-192, 2003.
Flora G., Lee
Y.W., Nah A., Hennig B., Maragos W., Toborek M.. Methamphetamine
potentiates HIV-1 Tat protein-mediated activation of redox-sensitive
pathways in discrete regions of the brain. Exp. Neurol., 179, 60-70,
2003.
Toborek M.,
Lee Y.W., Pu H., Malecki A., Flora G., Garrido R., Hennig B.,
Bauer H.C., Nath A.. HIV-Tat protein induces oxidative and inflammatory
pathways in brain endothelium. J. Neurochem., 84: 169-179, 2003.
Hennig
B, Toborek M, Robertson LW. Nutrition and proinflammatory mechanisms
of PCB toxicity in the vascular endothelium. Fresen. Environ. Bull.,
12: 240-244, 2003.
Meerarani P,
Smart EJ, Toborek M, Boissonneault GA, Hennig B. Cholesterol
attenuates linoleic acid-induced endothelial cell activation. Metabolism,
52:493-500, 2003.
Lee, Y.W., H.J.
Park, K.W. Son, B. Hennig, L.W. Robertson and M. Toborek.
2,2’4,4’,6’-Pentachlorobiphenyl (PCB 104) induces apoptosis of human
microvascular endothelial cells through the caspase-dependent activation
of CREB. Toxicol. Appl. Pharmacol., 189: 1-10, 2003.
Meerarani P,
Reiterer G, Toborek M, Hennig B. Zinc modulates PPAR-gamma
signaling and activation of endothelial cells. J. Nutr., 133: 3049-3055,
2003.
Ramadass P,
Meerarani P, Toborek M, Robertson LW, Hennig B. Dietary
flavonoids modulate PCB-induced oxidative stress, CYP1A1 induction and
AhR DNA binding activity in vascular endothelial cells. Toxicol. Sci.,
76: 212-219, 2003.
Garrido R,
King-Pospisil K, Son KW, Hennig B, Toborek M. Nicotine
upregulates nerve growth factor expression and prevents apoptosis of
cultured spinal cord neurons. Neurosci. Res., 47: 349-355, 2003.
Pu H, Tian J,
Flora G, Lee YW, Nath A, Hennig B, Toborek M: HIV-1
Tat protein upregulates inflammatory mediators and induces monocyte
invasion into the brain. Mol. Cell. Neurosci., 24: 224-237, 2003.
Garrido R,
Springer JE, Hennig B, Toborek M. Nicotine attenuates
arachidonic acid-induced apoptosis of spinal cord neurons by preventing
depletion of neurotrophic factors. J. Neurotrauma, 20: 1201-1213, 2003.
Saraswathi
V, Hammock BD, Newman JW, Meerarani P, Toborek M, Hennig B.
Involvement of CYP 2C9 in mediating the proinflammatory effects of linoleic
acid in vascular endothelial cells. J. Am. Coll. Nutr., 502-510, 2003.
András IE,
Pu H, Deli MA, Nath A, Hennig B, Toborek M. HIV-1 Tat
protein alters tight junction protein expression and distribution in
cultured brain endothelial cells. J. Neurosci. Res., 74: 255-265, 2003.
Toborek, M.,
Y.W. Lee, R. Garrido, S. Kaiser, and B. Hennig. Dietary
unsaturated fatty acids selectively induce an inflammatory environment
in human endothelial cells. Am. J. Clin. Nutr., 75: 119-125. 2002.
Park, H.J.,
Y.W. Lee, B. Hennig, and M. Toborek. Linoleic acid-induced
VCAM-1 expression in human microvascular endothelial cells is mediated
by the NF-kappa B-dependent pathway. Nutr. Cancer, 41: 126-134, 2002.
Toborek, M.,
Y.W. Lee, S. Kaiser, and B. Hennig. Measurement of
inflammatory properties of fatty acids in human endothelial cells. Methods
Enzymol., 352: 198-219, 2002.
Hennig,
B., Hammock B.D., R. Slim, M. Toborek, V. Saraswathi, and L.W.
Robertson. PCB-induced oxidative stress in endothelial cells: modulation
by nutrients. Int. J. Hyg. Environ. Health, 205: 95-102, 2002.
Hennig,
B., P. Meerarani, R. Slim, M. Toborek, A. Daugherty, A. Silverstone,
and L.W. Robertson. Proinflammatory properties of co-planar PCBs: in
vitro and in vivo evidence. Toxicol. Appl. Pharmacol., 181: 174-183,
2002.
Flora, G.,
Y.W. Lee, A. Nath, W. Maragos, B. Hennig and M. Toborek.
Methamphetamine-induced TNF-alpha gene expression and activation of
AP-1 in discrete regions of mouse brain: potential role of reactive
oxygen intermediates and lipid peroxidation. J. Molec. Neurosci. 2:
71-85, 2002.
Lee, Y.W., K.W.
Son, G. Flora, B. Hennig, A. Nath and M. Toborek. Methamphetamine
activates DNA-binding of specific redox-responsive transcription factors
in mouse brain. J. Neurosci. Res., 70: 82-89, 2002.
Lee YW, Hennig B,
Fiala M, Toborek M. Cocaine activates redox-regulated transcription
factors and induces TNF-alpha expression in human brain endothelial
cells. Brain Res, 920: 125-133, 2001.
Lee YW, Park HJ, Hennig
B, Toborek M. Linoleic acid induces MCP-1 gene expression in human
microvascular endothelial cells through an oxidative mechanism.
J Nutr Biochem, 12: 648-654, 2001.
Lee YW, Kühn H, Kaiser S,
Hennig B, Daugherty A, Toborek M. Interleukin-4 induces transcription
of the 15-lipoxygenase-I gene in human endothelial cells. J Lipid Res,
42: 783-791, 2001.
Hennig B, Toborek
M, McClain CJ. High-energy nutrients, fatty acids and endothelial cell
function: implications in atherosclerosis. J Am Coll Nutr, 20: 97-105,
2001.
Garrido R, Mattson MP, Hennig
B, Toborek M. Nicotine protects against arachidonic acid-induced
caspase activation, cytochrome c release, and apoptosis of cultured
spinal cord neurons. J Neurochem, 76: 1395-1403, 2001.
Hennig B, Toborek
M. Nutrition and Endothelial Cell Function: implications in Atherosclerosis.
Nutr Res, 21: 279-293, 2001.
Slim R, Hammock BD, Toborek
M, Robertson LW, Newman JW, Morisseau CHP, Watkins BA, Saraswathi V,
Hennig B. The role of methyl-linoleic acid epoxide and diol metabolites
in the amplified toxicity of linoleic acid and polychlorinated biphenyls
to vascular endothelial cells. Toxicol Appl Pharmacol, 171: 184-193,
2001.
Lee YW, Kühn
H, Hennig B, Neish AS, Toborek M. IL-4-induced oxidative stress
upregulates VCAM-1 gene expression in human endothelial cells. J Mol
Cell Cardiol, 33: 83-94, 2001.
Lee YW, Kühn
H, Hennig B, Toborek M. IL-4 induces apoptosis of endothelial
cells through the caspase-3-dependent pathway. FEBS Lett, 485: 122-126,
2000.
Krizbai IA,
Bauer H, Amberger A, Hennig B, Szabo H, Fuchs R, Bauer HC. Growth
factor-induced morphological, physiological and molecular characteristics
in cerebral endothelial cells. Eur J Cell Biol, 79: 594-600, 2000.
Hennig B,
Meerarani P, Ramadass P, Watkins BA, Toborek M. Fatty acid-mediated
activation of vascular endothelial cells. Metabolism, 49: 1006-1013,
2000.
Hennig B,
Slim R, Toborek M, Malecki A, Robertson LW. Effects of lipids and antioxidants
on PCB-mediated dysfunction of vascular endothelial cells. Cent Eur
J Public Health, 8 Suppl: 18-19, 2000.
Slim R, Toborek
M, Robertson LW, Lehmler HJ, Hennig B. Cellular glutathione status
modulates polychlorinated biphenyl-induced stress response and apoptosis
in vascular endothelial cells. Toxicol Appl Pharmacol, 166: 36-42, 2000.
Malecki A,
Garrido R, Mattson MP, Hennig B, Toborek M. 4-Hydroxynonenal
induces oxidative stress and death of cultured spinal cord neurons.
J Neurochem, 74: 2278-2287, 2000.
Garrido R,
Malecki A, Hennig B, Toborek M. Nicotine attenuates arachidonic
acid-induced neurotoxicity in cultured spinal cord neurons. Brain Res,
861: 59-68, 2000.
Toborek M,
Garrido R, Malecki A, Kaiser S, Mattson MP, Hennig B, Young
B. Nicotine attenuates arachidonic acid-induced overexpression of nitric
oxide synthase in cultured spinal cord neurons. Exp Neurol, 161: 609-620,
2000.
Slim R, Toborek
M, Robertson LW, Hennig B. Antioxidant protection against PCB-mediated
endothelial cell activation. Toxicol Sci, 52: 232-239, 1999.
Meerarani P,
Ramadass P, Toborek M, Bauer HC, Bauer H, Hennig B. Zinc protects
against apoptosis of endothelial cells induced by linoleic acid and
tumor necrosis factor alpha. Am J Clin Nutr, 71: 81-87, 2000.
Lab Personnel (photos)
