Mare and foal

 

Horse Genome Project

RECENT NEWS

International Equine Genome Mapping Workshop
The 8th Dorothy Russell Havemeyer Foundation International Equine Genome Mapping Workshop took place near Newmarket, UK from July 22 to 25, 2009...[more]

MEDIA ECLIPSE AWARD
Writers at the Louisville Courier Journal recently won the 2008 Media Eclipse Award for journalism based on an article about Thoroughbred racing and break-downs. They published a 3 part story, including genetics, track surfaces and medications. In connection with the genetics section they interviewed several members of the Horse Genome Project. See the accompanying links for the full stories on the 2008 Media Eclipse Award and the article itself.

Courier-Journal Web site wins award for horse project
Genetics may hold key to Injury-prone horses
[December 2008]

HORSE GENOME SEQUENCE COMPLETE
The first draft of the horse genome sequence was recently completed and deposited...
[JAVMA News, April 2007]

HORSE GENOME ASSEMBLED
Data on Equine Genome Freely Available to Researchers Worldwide
[NIH News, February 2007]

HORSE GENOME SEQUENCED
The first genome map of a horse is complete, providing scientists with new tools for investigating equine disease. [ April 2006]

 

CURRENT GENOMICS RESEARCH PROJECTS

None of us are really gene mappers nor molecular geneticists.  Before 1995, each of us was pursuing research on a disease, performance or behavior trait that was important to the health and welfare of horses.   But in 1995 we had observed the progress being made by the Human Genome Project and realized that genomic tools would allow us to make better progress toward our goals.  

Now that we have the whole genome sequence for the horse, our creative energies are focused on diverse projects, many of which are included in the list that follows this paragraph.  Some targets are simple genetic traits, such as cerebellar abiotrophy, dwarfism and lavender foal syndrome, that are probably caused by a single gene defect.  Others, such as osteochondrossis dessicans, laminitis and athleticism are probably complex and have multiple genes plus management factors governing the manifestation of the trait.  Other traits are not inherited, such as herpesvirus infections, some aspects of laminitis and cartilage repair, but we are still interested in knowing how genes are regulated in connection with the conditions.  Knowing this information will allow us to develop therapeutic treatments or devise management practices that will produce healthier horses.

 

Research Projects Using Tools from the Whole Genome Sequence*

Trait

Breed

Institution

Gene Discovery Projects

Allergic Eczema

Icelandic

Swedish University of Agriculture

Anterior Segment Dysgenesis

Rocky Mountain Horse

Texas A & M University

Athletic Performance

Thoroughbred

University College Dublin, Ireland

Athletic Performance

Swedish Trotters

Sweden

Behavior

Swiss Franches Montagnes

University of Berne, Switzerland

Cerebellar Abiotrophy

Arabian

University of California - Davis

Cervical Stenotic Myelopathy

Thoroughbred

University of Kentucky

Chronic Progressive Lymphedema

Belgian, Shire, Clydesdale

University of California - Davis

Contracted Foal Syndrome

Thoroughbred

University of Kentucky

Cytogenetic Abnormalities/Infertility

Thoroughbred, others

University of Kentucky

Dwarfism

Miniature

University of Kentucky

Extreme Lordosis

Saddlebred

University of Kentucky

Immune Mediated Myopathy

Quarter Horse

University of Minnesota/ Texas A&M

Fell Pony Syndrome

Fell Pony

Texas A & M, Uppsala

Fertility and Reproduction

Various

University of Hannover, Germany

Fracture and Tendon Injury

Thoroughbred

Animal Health Trust,
Royal Veterinary College, United Kingdom

Laminitis

Thoroughbred

University of Kentucky

Lavender Foal

Arabian

Cornell University

Musculo-Skeletal Defects

French breeds

INRA, France

Navicular Disease

Warmblood

University of Hannover, Germany

Osteochondrosis Dissicans

Dutch Warmblood

University College Dublin, Ireland

Osteochondrosis Dissicans

Thoroughbred

Animal Health Trust, United Kingdom

Osteochondrosis Dissicans

Hannoverian Warmblood

University of Hannover, Germany

Osteochondrosis Dessicans

Standardbred, Quarter Horse, Belgian

University of Minnesota/
Norwegian Veterinary School

Pasture-Associated Laminitis

Ponies and others

Virginia Technical University

Photosensitive Trichothiodystrophy

Curly Horse

Texas A & M University

Polysaccharide Storage Myopathy 2

Quarter Horse

University of Minnesota

Recurrent Airway Obstruction

Swiss Warmblood

University of Berne, Switzerland/
Animal Health Trust, United Kingdom

Recurrent Airway Obstruction

Quarter Horse

Michigan State University,
Cornell University

Recurrent Exertional Rhabdomyolysis

Thoroughbred

Animal Health Trust, United Kingdom

Recurrent Exertional Rhabdomyolysis

Thoroughbred

University of Minnesota

Recurrent Uveitis

Appaloosa

University of Minnesota/
Texas A&M University

Sarcoid Tumors

Quarter Horses

Cornell University

Shivers Muscle Tremors

Belgian

University of Minnesota

Stereotypic behavior (Cribbing)

Thoroughbred, Quarter horse, others

University of California - Davis

Suspensory Ligament Desmitis

Paso Fino

Texas A&M University

White Markings

Swiss Franches Montagnes

University of Berne, Switzerland

Gene Expression Projects


Maturation and Repair of Articular Cartilage

Various

University of Kentucky

Allergic Eczema

Icelandic

Swedish Agricultural University

Alternations of Maternal Immunity During Pregnancy

Various

Cornell University

Athletic Performance

Trotters

Swedish Agricultural University

Common Variable Immunodeficiency

Various

Cornell University

Early Embryonic Development

Various

Texas A&M University

Equine Placental Development

Various

Cornell University

Fertility and Reproduction

Various

University of Hannover, Germany

Immunity to Equine Herpes Virus Type 1

Various

Cornell University

Immunity to Rhodococcus equi in foals

Various

Cornell University

Improved Safety of Intra-articular
Glucocorticoid Therapy

Various

University of Kentucky

Muscle Response to Exercise

Thoroughbred

University College Dublin, Ireland

Osteochondrosis Dessicans

Standardbred

University of Minnesota/
Norwegian Veterinary School

Recurrent Airway Obstruction

Various

Cornell University

Recurrent Airway Obstruction

Warmblood

University of Berne, Switzerland/
Animal Health Trust, United Kingdom

Recurrent Airway Obstruction

Quarter Horse, others

Michigan State University

Studies of Equine Allergic Diseases

Various

Cornell University

Suspensory Ligament Desmitis

Paso Fino

Texas A&M University

 

* This list is taken from the Morris Animal Foundation Consortium Project on Equine Medical Genetics.  This is a comprehensive project designed to create shared genomic tools and enhance collaboration among laboratories.   Scientists also obtain additional funds for research projects related to these topics from other funding agencies, including the American Quarter Horse Association, Home of Rest for Horses, Grayson-Jockey Club Research Foundation, United States Department of Agriculture,and the American Saddlebred Horse Association.

 

running horses

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