Claysville is a northeastern Harrison county community on the Licking River at US 62. It was established early in the nineteenth century as Marysville, named for the wife of Benjamin Harrison, and was once an important river port for tobacco and other products. It was incorporated as Claysville, honoring Henry Clay, in 1821. The Marysville post office opened in 1816 and was renamed Claysville in 1825. It closed in 1917.