Millersburg is a northern Bourbon county town located where US 68 crosses Hinkston Creek. It is named for John Miller, who founded the town on his farm in 1798. The post office opened in 1804 as Millersburgh, changing to Millersburg in 1893. The population in 1990 was 937.

The Millersburg Military Institute operated here from 1893 until 2006.