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"This amount of funding is going to help the researchers change the face of how our universities and medical centers deal with lung cancer and help provide us with critical information in this fight."

-- Gov. Paul Patton

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Oct. 17, 2001 (Frankfort, Ky.) -- Gov. Paul Patton today handed out $3.8 million of Tobacco Settlement money to 20 researchers from the University of Kentucky and University of Louisville for lung cancer research.

The grants are part of the Lung Cancer Research Project that Governor Patton and lawmakers created in the 2000 General Assembly to combined efforts of UK and U of L to become national leaders in lung cancer basic research, early detection, diagnosis and treatment.

"Lung cancer is a significant problem in Kentucky. About 3,000 Kentuckians die each year from it. This type of cancer kills more Kentuckians annually than breast, colon, pancreas and prostate cancers combined," Patton said. "These figures are staggering and make the mission and importance of our universities' research even greater."

The Lung Cancer Research Project is a 20-year initiative that was designed to receive 20 percent of all moneys in the Tobacco Master Settlement Agreement for this collaborative partnership between the two universities. The project's nine-member board helped select the 20 grant recipients from a total of 54 initial requests.

Dr. Donald Miller, director of the James Graham Brown Cancer Center at the University of Louisville, and Dr. Alfred Cohen, director of the Markey Cancer Center at the University of Kentucky, will help oversee the direction of the 20 grants, which were funded for two years.

"This amount of funding is going to help the researchers change the face of how our universities and medical centers deal with lung cancer and help provide us with critical information in this fight," Patton said.

The researchers who received grants include:

Name/University Research

Mansoor Ahmed: UK, TGF-beta signaling and radiation response in lung carcinoma

Douglas A. Andres: UK, Novel ras-related GTPase in lung cancer

Paula J. Bates: U of L, Nucleolin: A novel marker and therapeutic target for lung cancer

Haribabu Bodduluri: U of L, Role of G-protein coupled receptor mediated motility in lung cancer

Stephen A. Brown: UK, Radioprotective agents in NSCLC therapy

John W. Eaton: U of L, Pro-inflammatory and clastogenic actions of smoke-borne free fatty acids

H. Leighton Grimes: U of L, Involvement of the GF11 oncoprotein in human lung cancer

Ramesh C. Gupta: UK, Etiology and prevention of lung cancer: Biomarker development in clinical studies

David A. Hein: U of L, Environmental genomics and molecular epidemiology of lung cancer: Functional characterization of N-acetyltransferase-1 and -2 genetic polymorphisms

Louis B. Hersh: UK, A gene therapeutic approach for the treatment of lung cancer

Edward Hirschowitz: UK, Therapeutic investigation of dendritic cell vaccines in NSCLC

Glenn McGregor: U of L, Mechanisms of BPDE-induced mutagenesis and mutation avoidance

Marcos A. Oliveira: UK, A novel chemo-radio sensitizing target: PARP-2 activation domain

Stephen C. Peiper: U of L, Role of G-protein coupled receptors in lung cancer biology: Novel approaches to block proliferation and spread

Gordon D. Ross: U of L, Oral adjuvant immunotherapy of lung carcinoma

William St. Clair: UK, Novel anticancer agents to promote the efficacy of contemporary or GRID radiation therapy for treatment of lung cancer

Sandra Sephton: U of L, Psychosocial effects in lung cancer outcomes

Haval Shirwan: U of L, A novel approach to tumor vaccination

H. Peter Spielman: UK, Pre-clinical studies of novel ras function inhibitors to treat lung cancer

John R. Yannelli: UK, Use of dendritic cells to present non-small cell lung cancer associated antigens

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