College of Medicine is hosting a free seminar, "Weight
Management in Adolescence: Suggestions for Teens and
Parents," at 7 p.m. Monday, July 29, in 115 UK College
of Nursing/Health Sciences Learning Center. For more
information, call (859) 257-4058.
10, 2002 (Lexington, Ky.) --
A drug used to treat depression and smoking cessation
may be an effective tool in the fight against obesity,
according to a 48-week University of Kentucky study
that will be published in July's Obesity Research,
the leading obesity journal.
SR (pronounced bu-pro-pee-on), which has been on the
market for more than 10 years, can be an effective
tool to combat obesity when combined with diet and
exercise, according to the findings of a multi-center,
double-blind, randomized study led by James W. Anderson,
M.D., professor of medicine and clinical nutrition
in the UK College of Medicine.
clearly is increasing in this country, and the treatments
we offer aren't very effective," Anderson said. "There
are no magic bullets for treating obesity, but this
does give us another tool in the toolbox. Diet and
exercise are still keys to weight loss."
first 24 weeks of the study, 227 people considered
clinically obese, ages 18 to 65, either took a placebo,
300 milligrams of bupropion SR daily, or 400 milligrams
of bupropion SR daily.
also were on a restricted diet - 600 fewer calories
per day than required to maintain the participant's
normal weight - using two meal replacements per day.
They also recorded miles walked, kept a lifestyle
diary, and received dietetic counseling every two
to four weeks. Individuals assigned to 400 milligrams
a day lost 10.1 percent of their initial body weight,
compared to 7.2 percent for 300 milligrams and 5 percent
for the placebo. In the second 24 weeks of the study,
192 participants who completed the study received
bupropion and sustained their weight loss, Anderson
said. During the second phase of the study, participants
maintained a moderate exercise regimen.
end of the second session, those receiving 400 milligrams
a day maintained an 8.6 percent loss of their initial
body weight. Those receiving 300 milligrams maintained
a 7.5 percent loss of their initial body weight. The
drug, which had few side effects, is thought to work
on neurochemicals in the brain that control responses
to certain stimuli: for example, habitual behaviors
next will study weight loss and adolescents using
the same drug and other diet regimens.
is a major problem in this country, particularly in
Kentucky," Anderson said. "For example, 70 percent
of heart attacks in women are related to obesity.
We need all the weapons we can gather to fight this