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Professor Gets Grant to Study Enzymes

Contact: Ralph Derickson

Photo of Anne-Frances Miller
Anne-Frances Miller

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Anne-Frances Miller’s research group will use the NIH funding to employ a special nuclear magnetic resonance technique to observe individual atoms of the cofactor used by a large class of diverse and crucial enzymes. This process, she said, “will give us ‘inside information’ on exactly how the engine works, with atomic and even electronic detail.”

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LEXINGTON, Ky. (Oct. 3, 2003) -- Anne-Frances Miller, associate professor of chemistry and biochemistry and director of the Nuclear Magnetic Resonance Facility at the University of Kentucky College of Arts and Sciences, has been awarded a $150,000 grant by the National Institutes of Health (NIH) to study enzymes.

Miller said most of the thousands of chemical reactions on which our lives depend are performed by catalysts called enzymes. “While enzymes are composed largely of protein, these enzymes very often employ a reactive ingredient called a cofactor to do the actual chemistry, just as an engine employs a spark plug to initiate combustion,” she explained.

Miller’s research group will use the NIH funding to employ a special nuclear magnetic resonance technique to observe individual atoms of the cofactor used by a large class of diverse and crucial enzymes. This process, she said, “will give us ‘inside information’ on exactly how the engine works, with atomic and even electronic detail.”

Miller came to the University of Kentucky in 1999 from The Johns Hopkins University. She received her Bachelor of Science Honors in Genetics at the University of Guelph in her native Canada and then earned a doctorate in biophysical chemistry from Yale University.

Miller has been involved in numerous research projects and grants, including her most current NIH-funded research.


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