Robert Blouin
Pharm.D.

Selected Publications

Rockich K, Blouin RA. The effect of the acute phase response on the pharmacokinetics of chlorzoxazone and cytochrome P450 2E1 in vitro activity in rats. Drug Metab Dispos, accepted

Watson AM, Poloyac S, Howard G, Blouin RA. The effect of leptin on hepatic microsomal and cytosolic enzymes in ob/ob mice. Drug Metab Dispos, 1999

Warren GW, Poloyac SM, Gary DS, Mattson MP, Blouin RA. Hepatic cytochrome P450 expression in the TNF-receptor (p55/p75) knockout mice following endotoxin administration. J Pharmacol Exp Ther, 288:945-950, 1999

Watson AM, Warren G, Howard G, Shedlofsky SI, Blouin RA. Activities of conjugating and antioxidant enzymes following endotoxin exposure. J Biochem Molecular Toxicol, 13:63-69, 1999

Roe AL, Howard G, Blouin RA, Snawder JE. Characterization of cytochrome P450 and glutatione S-transferase activity and expression in male and female ob/ob mice. Int J Obesity, 23:48-53, 1999

Roe AL, Howard G, Blouin RA. Characterization of nuclear protein binding (AP-1, GR, and STAT) in the genetically obese (fa/fa) Zucker rat. Life Sciences, 63:1339-1346, 1998

Roe AL, Howard G, Hou Q, Shedlofsky SI, Blouin RA. The effect of high-dose endotoxin on CYP3A expression. Pharm Res, 15:1603-1608, 1998

Shedlofsky SI, Israel BC, Tosheva R, Blouin RA. Endotoxin depresses hepatic cytochrome P450-mediated drug metabolism in women. Br J Clin Pharmacol, 43:627-632, 1997

Roe AL, Blouin RA, Howard G. In vivo phenobarbital treatment increases protein binding to a punitive AP-1 site in the CYP2B2 promoter. Biochem Biophys Res Comm, 228:110-114, 1996

Zannikos PN, Bandyopadhyay AM, Robertson LW, Blouin RA. Expression of the CYP3A and CYP2C11 enzymes in a nutritionally obese rodent model: Response to phenobarbital. Int J Obesity, 18:369-374, 1994

Shedlofsky SI, Israel BC, McClain CJ, Hill DB, Blouin RA. Endotoxin administration to humans inhibits hepatic cytochromoe P450-mediated drug metabolism. J Clin Invest, 94:2209-22214, 1994

Toler SM, Young B, McClain C, Young B, Shedlofsky SI, Bandyopadhyay AM, Blouin RA. The effect of head trauma on the regulation and expression of hepatic CYP2C11 and CYP3A in Fisher-344 rats. Drug Metab Dispo, 21:1064-1069, 1993

Blouin RA, Chaudhary I, Bandyopadhyay AM, Robertson LW, Gemzik B, Parkinson A. Cytochrome P450  2B enzyme induction defect following phenobarbital treatment in the fa/fa rat: Molecular characterization. Arch Biochem Biophys, 303:313-320, 1993

Israel BC, Blouin RA, McIntrye W, Shedlofsky SI. Effects of interferon-alpha monotherapy on hepatic drug metabolism in cancer patients. Br J Clin Pharmacol, 36:229-235, 1993

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