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howardg@pop.uky.edu
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Georgette
Howard
Ph.D.
Associate Professor
Pharmaceutical Sciences Division
Dr. Howard's research in the area of neuroendocrinology focuses on the role
of neuropeptides in the development of obesity and diabetes. The sympathetic
neuropeptide, galanin, is an important neuromodulator of food intake and
insulin secretion. Current research focuses on the tissue-specific and aberrant
regulation of galanin gene expression during obesity-associated diabetes in
the ob/ob mouse mutant. Molecular techniques such as electrophoretic
mobility shift assays, cell culture transfections, and RNA analysis are being
utilized in order to map critical regulatory elements involved in regulating
galanin gene expression in both normal and pathophysiological states.
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