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PHR 647 - Review
Georgette
Howard, Ph.D.
Glossary of terms that you should know:
1. Nucleus
- Genome
- Chromosome
- Chromatin
- DNA
- Gene
- Nucleotides
2. Gene Expression
- Transcription
- RNA polymerase
- RNA
- Splicing
- Translation
- Ribosomes
- Protein
- Protein modifications
3. Anatomy of a Gene
- Promoter/Enhancer
- Transcription factors
- Exons
- Introns
4. Mutations - Mol. Cell Biology Chpt 8, 26.
- Translocations
- Point mutations
- Carcinogen
- Oncogenes
- Tumor suppressors
- Predisposition
- Polygenic
5. Cell cycle - MCB Chpt. 25
- Stages of cell division
- Mitosis
- Stem cells
- Quiescent cells
- Differentiated cells
- Germ cells
- Prokaryote
- Eukaryote
6. Med. Genetics - MCB Chpt. 8,10
- Allele
- Mutant
- Wild-type
- Carrier
- Heterozygote
- Homozygote
- Dominant
- Recessive
- Autosomal
- X-linked
- Genome Initiative
7. Techniques
- Diagnostic:
- Radioactive probe
- Gel electrophoresis
- Southern hybridization
- Northern hybridization
- Western hybridization
- Autoradiograph
- PCR
- DNA Sequencing
- Monoclonal antibodies
- Therapeutic:
- Cloning
- Restriction enzymes
- Vector
- Foreign DNA
- Recombinant DNA
- Ligation
- Bacterial host (E. coli)
- cDNA
8. Therapeutics
- Recombinant
- proteins
- Antigenicity
- Stability
- Delivery
- Gene Therapy
- Ex Vivo
- In Vivo
- Retroviral
- Adenoviral
- Integration
- Replication
- Host
- Receptor
- Liposomes
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