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Dosage Forms (Wyeth-Ayerst)
Tablets: 12.5 mg (orange, #19), 25 mg (white, #27), 50 mg (pink, #227)
Syrup, Phenergan Plain: 6.25 mg per 5 ml
Syrup, Phenergan Fortis: 25 mg per 5 ml
Suppositories: 12.5 mg, 25 mg, and 50 mg
Injection: 25 mg/mL and 50 mg/mL
Adult Dosing Guidelines
- For management of allergic rhinitis, allergic conjunctivitis, uncomplicated allergic skin manifestations of urticaria and angioedema, amelioration of allergic reactions to blood plasma, dermographisms, and as adjunctive therapy in anaphylactic reactions:
Oral: 6.25 to 12.5 mg 3-4 times daily as needed, or 25 mg at bedtime.
Injection and rectal: 25 mg initially, repeated in 2 hours if necessary. Resume oral therapy when possible. Preferred parenteral route for injection is deep intramuscular.
- For the control of motion sickness: 25 mg twice daily. Initial dose should be taken 1/2 to 1 hour before anticipated travel, then 8-12 hours later as needed.
- For the control of nausea and vomiting: 12.5 mg to 25 mg every 4-6 hours as needed.
- For sedation: 25 mg to 50 mg at bedtime.
Pediatric Dosing Guidelines
- For the control of motion sickness: 12.5 mg to 25 mg twice daily.
- for sedation: 12.5 mg to 25 mg at bedtime.
General Information
Promethazine competitively inhibits histamine at the H1 receptor site, causing a spasmolytic and decongestant effect. Antihistamines will prevent, but not reverse, histamine-mediated reactions. Therapeutic effects begin to occur 20 minutes after administration and last for 4-6 hours. Peak effects are seen 45-60 minutes after administration. Use is contraindicated in patients with lower respiratory tract symptoms (including asthma).
Adverse Reactions/Side Effects
Drowsiness, rash, nausea, vomiting, blurred vision.
Natural Products or Nutritional Interactions (if applicable)
May be taken with food or milk if GI upset occurs. Avoid alcohol while taking this medication. |