Endotoxin and Other Toxic Bacterial Cell Wall Components
In the outer membrane of Gram-neg. bacteria.
- Exerts it activity when bacteria are lysed.
- Lipid A is the toxic portion.
- Activates complement and stimulation of release of cytokines (hyperproduction)
- TNF-alpha, IL-1, IL-6, IL-8, platelet activating factor.
- Shock, endothelial damage, MOSF