Amphotericin B Lipid Formulations

• Rapidly cleared from blood with large Vd

• Concentrates in the RES - liver, spleen, lymph nodes.

• Tolerated doses in man

  • ABLC - 40 mg/kg
  • DCAB - 1.5 mg/kg

• LD50

  • ABLC - > 40 mg/kg
  • DCAB - 3 mg/kg

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