Acyclovir
Pharmacokinetics
- Oral bioavailability - 15-21%
- Prodrug valaciclovir - (L-valine ester of acyclovir) - 3-5 x greater oral bioavailibility compared to acyclovir.
- Protein binding - < 20%
- CSF - 1/2 of plasma levels.
- t1/2 - 2.5 - 3 hours.
- Renal excretion - 60-91%