Peter Crooks
Ph.D.

Selected Recent Publications:

Research Publications/Presentations

“Residence Time and Half-Lives of Nicotine Metabolites in Rat Brain after Acute Peipheral Admintration of

[2’-14C]Nicotine”. B Omar Ghosheh, Linda P. Dwoskin, Wenkui Li, and Peter A. Crooks, Drug Metab.

Disposit., 1999, in press.

“A Novel Enantioselective synthesis of (S)-(-)- and (R)-(+)-Nornicotine via Alkylation of a Chiral 2-Hydroxy-

3-pinanone Ketimine Template”. By Jason H. Swango, Balwinder S. Bhatti, Muhammad M. Qureshi, and Peter A. Crooks, Chirality, 11, 316-318, 1999.

“S-(-)-Cotinine, the Major Brain Metabolite of Nicotine, Stimulates Nicotinic Receptors to Evoke

[3H]Dopamine Release from Rat Striatal Slices in a Calcium-Dependent Manner”. By Linda P. Dwoskin,

LiHong Teng, Susan T. Buxton, and Peter A. Crooks, J. Pharmacol. Exp. Therap., 1999, 288, 905-911.

“Development of a Novel Class of Subtype-Selective Nicotinic Receptor Antagonists: Pyridine N-Substituted

Nicotine Analogues”. By Linda P. Dwoskin, Lincoln H. Wilkins, James R. Pauly, and Peter A. Crooks, Ann.

New York Acad. Sci., 1999, 868, 617-618.

“Acute and Chronic Effects of Nornicotine on Locomotor Activity in Rats: Cross-Reactivity to Nicotine.”. By

Linida P. Dwoskin, Peter A. Crooks, Melinda B. Marion, LiHong Teng and Michael E. Bardo

Psychopharmacology, 1999, 145, 442-451.

“Synthesis of (E)-[Methyl-d3-]-4-(pyridinyl)-3-buten-1-amine; a Deuterated Analogue of the Tobacco Alkaloid

and Nicotine Metabolite: Metanicotine.” By Peter A. Crooks, Alain Ravard and Gary D. Byrd, J. Labelled

Comp. Radiopharm., 1998, LXI, 1165-1171.

“The Heterocyclic Substituted Pyridine Derivative (+/-)-2-Azabibicyclo (2.2.1)-hept-5-ene (RJR-2429); A

Selective Ligand at Nictoinic Acetylcholine Receptors:. By M. Bencherif, J.D. Schmitt, B.S. Bhatti, P.A.

Crooks, W.S. Caldwell, M.E. Lovette, K. Fowler, L. Reeves, and P.M. Lippiello, J.Pharmacol. Exp. Ther.,

1998, 284, 886-894.

“Lobeline Displaces [3H]Dihydrotetrabenazine Binding and Releases [3H]Dopamine from Rat Striatal Synaptic Vesicles: Comparison with d-Amphetamine”. By LiHong Teng, Peter A. Crooks and Linda P. Dwoskin, J.Neurochem., 1998, 71, 258-265.

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