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Kostenbauder Professorship

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Bradley Anderson, Ph.D.
Chair, Division of Pharmaceutical Sciences
H.B. Kostenbauder Professor in Pharmaceutical Sciences

RESEARCH PUBLICATIONS

D. Singhal, M.E. Morgan, and B.D. Anderson, "Pharmacokinetics and Bioavailability of a Tripeptide HIV Protease Inhibitor versus Route of Administration in Chronically Catheterized Rats," submitted.

B.D. Anderson, "Can the Blood-Brain Barrier Permeability of a Compound be Predicted?" in Brain Barrier Systems, O. Paulson, G.M. Knudsen, T. Moos, Eds., Alfred Benzon Symposium 45, Munksgaard, Copenhagen, in press.

M.D. Johnson and B.D. Anderson, "The Use of Cultured Cerebral Capillary Endothelial Cells in Modeling the Central Nervous System Uptake of 2', 3'-Dideoxynucleosides. I. Developing a Model for Simple Passive Diffusion," submitted.

T.-X. Xiang and B.D. Anderson, "Solute Permeation Across Lipid Bilayers, I. Relative Partition Coefficients as Studied by Molecular Dynamics Simulation," J. Chem. Phys., accepted.

T.-X. Xiang and B.D. Anderson, "Influence of Chain Ordering on the Selectivity of DPPC Bilayer Membranes to Permeant Size and Shape," Biophysical J., 75, 2658-2671 (1998).

T.-X. Xiang, Y.-H. Xu, and B.D. Anderson, "The Barrier Domain for Solute Permeation Varies with Lipid Bilayer Phase Structure," J. Membrane Biol., 165, 77-90 (1998).

S. Venkatesh, J. Li, K.D. Caldwell and B.D. Anderson, "Compositional Heterogeneity in Parenteral Lipid Emulsions after Sedimentation Field Flow Fractionation," J. Pharm. Sci., 87, 859-866 (1998).

D. Singhal and B.D. Anderson, "Optimization of the Local Inhibition of Intestinal Adenosine Deaminase (ADA) by Erythro-9-(2-Hydroxy-3-Nonyl)-Adenine: Enhanced Oral Delivery of an ADA-Activated Prodrug for Anti-HIV Therapy," J. Pharm. Sci., 87,578-585 (1998).

D. Singhal, N.F.H. Ho, and B.D. Anderson, "Absorption and Intestinal Metabolism of Purine Dideoxynucleosides and an Adenosine Deaminase-Activated Prodrug of 2'-3'-Dideoxyinosine in the Mesenteric Vein Cannulated Rat Ileum," J. Pharm. Sci., 87, 569-577 (1998).

T.-X. Xiang and B.D. Anderson, "Phase Structures of Binary Lipid Bilayers as Revealed by Permeability of Small Molecules," Biochm. Biophys. Acta., 1370, 64-76 (1998).

M.E. Morgan, K. Liu, and B.D. Anderson, "Microscale Titrimetric and Spectrophotometric Methods for Determination of Ionization Constants and Partition Coefficients of New Drug Candidates," J. Pharm. Sci., 87, 238-245 (1998).

D. Singhal, M.E. Morgan, and B.D. Anderson, "Role of Brain Tissue Localized Purine Metabolizing Enzymes in the Central Nervous System Delivery of Anti-HIV Agents 2'-B-Fluoro-Dideoxyadenosine in Rats," Pharm. Res., 14, 786-792 (1997).

R.G. Strickley and B.D. Anderson, "Solid-State Stability of Human Insulin II. Effect of Water on Reactive Intermediate Partitioning in Lyophiles from pH 2-5 Solutions - Stabilization Against Covalent Dimer Formation," J. Pharm. Sci., 86, 645-653 (1997).

T.-X. Xiang and B.D. Anderson, "Permeability of Acetic Acid Across Gel and Liquid-Crystalline Lipid Bilayers Conforms to Free-Surface-Area Theory," Biphys. J., 72, 223-237 (1997).

M.D. Johnson and B.D. Anderson, "Localization of Purine Metabolizing Enzymes n bovine Brain Microvessel Endothelial Cells: An Enzymatic Blood-Brain Barrier for Dideoxynucleosides?" Pharm. Res., 13, 1881-1886 (1996).

D.L. Teagarden, B.D. Anderson, and W.J. Petre, "The Distribution and chemical Kinetics of Prostaglandin E, in Lipid Emulsions," Adv. Drug Deliv. Rev., 20, 155-164 (1996).

Room 327-G Pharmaceutical Sciences - Rose Street, Lexington, KY 40536-0082 - Phone (859) 257-7896 - Fax (859) 323-0242