RECENT PUBLICATIONS, CURRENT AND FORMER STUDENTS AND POSTDOCS

Singh, D. K., and Porter, T.D.  (2006) Inhibition of sterol 4a-methyl oxidase is the principal mechanism by which garlic decreases cholesterol synthesis.  J. Nutr. 136, 1S-6S.

Mokashi, V., and Porter, T.D.  (2005) Supernatant protein factor requires phosphorylation and interaction with Golgi to stimulate cholesterol synthesis in hepatoma cells.  Arch. Biochem. Biophys. 435, 175-181 [abstract].

Mokashi, V., Singh, D.K., and Porter, T.D.  (2005) Supernatant protein factor stimulates HMG-CoA reductase in cell culture and in vitro.  Arch. Biochem. Biophys. 433, 474-480 [abstract].

Mokashi, V., Singh, D.K., and Porter, T.D.  (2004) Rat supernatant protein factor-like protein stimulates squalene monooxygenase and is activated by protein kinase A.  Biochem. Biophys. Res. Commun. 316, 688-692 [abstract].

Porter, T.D.  (2004) Jud Coon: 35 Years of P450 research, a synopsis of P450 history.  Drug Metab. Dispos. 32, 1-6 [abstract].

Mokashi, V., Li, L., and Porter, T.D.  (2003) Cytochrome b₅ reductase and cytochrome b₅ support the CYP2E1-mediated activation of nitrosamines in a recombinant Ames test.  Arch. Biochem. Biophys. 412, 147-152 [abstract].

Singh, D.K., Mokashi, V., Elmore, C.L., and Porter, T.D.  (2003) Phosphorylation of supernatant protein factor enhances its ability to stimulate microsomal squalene monooxygenase.  J. Biol. Chem. 278, 5646-5651 [abstract]

Porter, T.D.  (2003) Supernatant protein factor and tocopherol-associated protein: An unexpected link between cholesterol synthesis and vitamin E  (Invited review).  J. Nutr. Biochem. 14, 3-6. [abstract]

Porter, T.D.  (2002) The Roles of Cytochrome b₅ in Cytochrome P450 Reactions (Invited review).  J. Biochem. Mol. Toxicol. 16, 311-316.  [abstract]

Elmore, C.L., and Porter, T.D.  (2002) Modification of the nucleotide-cofactor binding site of cytochrome P450 reductase to enhance turnover with NADH in vivo.  J. Biol. Chem. 277, 48960-48964. [abstract]

Gupta, N., and Porter, T.D.  (2002) Inhibition of human squalene monooxygenase by selenium compounds.  J. Biochem. Mol. Toxicol. 16, 18-23.  [abstract]

Cooper, M.T. and Porter, T.D.  (2001) Cytochrome b₅ coexpression increases the CYP2E1-dependent mutagenicity of dialkylnitrosamines in methyltransferase-deficient strains of Salmonella typhimurium.  Mutation Res. 484, 61-68.  [abstract]

Gupta, N., and Porter, T.D.  (2001) Garlic and garlic-derived compounds inhibit human squalene monooxygenase.  J. Nutrition 131, 1662-1667.  [abstract]

Laden, B.P., and Porter, T.D.  (2001) Resveratrol inhibits human squalene monooxygenase.  Nutrition Res. 21, 747-753.  

Laden, B.P., and Porter, T.D.  (2001) Inhibition of human squalene monooxygenase by tellurium compounds: Evidence of interaction with vicinal sulfhydryls.  J. Lipid Res. 42, 235-240.  [abstract]

Cooper, M.T., and Porter, T.D. (2000)  Mutagenicity of nitrosamines in methyltransferase-deficient strains of Salmonella typhimurium coexpressing human cytochrome P450 2E1 and reductase.  Mutation Res. 454, 45-52.  [abstract]

Laden, B.P., Tang, Y., and Porter, T.D.  (2000) Cloning, heterologous expression and enzymological characterization of human squalene monooxygenase.  Arch. Biochem. Biophys. 374, 381-388.  [abstract]

Students and Postdoctoral Scientists

Current Students and Postdocs

2002-          Li Li (Pharmaceutical Sciences)

2003-          Elżbieta Stolarczyk (Pharmaceutical Sciences)

Former Students

1992-97      Dr. Yinzi Tang, Director of Business Development, WuXi PharmaTech Co., Ltd., Shanghai, China

1995-02      Dr. Matthew Cooper, Principal Scientist, Group Leader of Toxicogenomics & In Vitro Toxicology, Roche Palo Alto, Palo Alto, CA

1997-00      Dr. Brian Laden, Office of Technology Transfer, Vanderbilt University, Nashville, TN

1999-03      Dr. C. Lee Elmore, Postdoctoral Scientist with Dr. Rowena Matthews, Dept. of Biological Chemistry, University of Michigan, Ann Arbor

2001-04      Dr. Vishwesh Mokashi, Postdoctoral Scientist with Dr. Alan Daugherty, Depts. of Internal Medicine and Physiology, University of Kentucky

Former Postdoctoral Associates

1993-94      Dr. Jinsheng Dong, Senior Staff Researcher with Dr. Alan Hinnebusch, NICHD, NIH

1995-98      Dr. Shinyu Chang, Scientist with Hyseq, Inc., Sunnyvale, CA

2000-01      Dr. Nisha Gupta, Postdoctoral Scientist with Dr. Aron B. Fisher, Institute of Environmental Medicine, University of Pennsylvania, Philadelphia, PA 

2001-04      Dr. Dev Karam Singh, Instructor, Dept. of Medicine, Diabetes and Metabolism, University of Illinois at Chicago 

                 Andrew Sauerbeck