1. Systems Biology Component - Directed by Dr. Black

2. Bioinformatics/Biostatistical Analysis Component - Directed by Dr. Stromberg

3. Proteomics Component - Directed by Dr. Zhu

4. Analytical Component - Directed by Dr. Wei

6. Bioanalytical Component - Directed by Dr. Morris

The overall activity of the Research Support Core is managed by Dr. Morris in close collaboration with the coordinators of individual components, Dr. Hennig (the Director of UK-SRP) and the Administration Core, and the Project Leaders of all individual grants.

The Specific Aims of the Research Support Core are to provide laboratory and statistical services, equipment, and technical support, and to facilitate access to new technologies (particularly in the areas of systems biology, bioinformatics, and proteomics) for multiple SRP investigators by:

1) Generation of a central database which will combine diverse data generated by all research projects. This database will provide a uniform platform for computational data analysis, which will be shared among all projects. The systems biology approaches will then be implemented to generate new hypotheses and to create predictive models to better anticipate the effects of nutrition on toxicity of Superfund chemicals;

2) Establishing and implementing a variety of state-of-the-art proteomics, bioinformatics, PCB and bioanalytical analysis procedures that are required by all investigators;

3) Providing assistance and consultations for data analysis and experimental design as required by individual investigators of the UK-SRP; and

4) Rigorous quality control of all aspects of the performed research.