Banner Link to UK Academy for Undergraduate Excellence Division of Undergraduate Education

The Office of Undergraduate Research

Elizabeth "Megan" Flynn

Mechanism of multiple lysine methylation by the SET domain enzyme Rubisco LSMT
Mentor: Dr. Robert L. Houtz

Megan's Beckman research proposal can be found at the bottom of this page.

Megan entered the University of Kentucky as a Governor's Scholar and was awarded the UK Bluegrass Merit Scholarship from 2000-2004. She graduated in May 2004 Summa Cum Laude with duel degrees in Agricultural Biotechnology and Spanish and with Honors from the Honors Program and the Department of Hispanic Studies. She went on to receive her Ph.D in Molecular and Cellular Biology from the University of California San Fransisco for which she was awarded full-tuition and a stipend. She completed three semesters of law school at Hastings College of Law at UC San Fransisco where she plans to finish her law degree. She currently serves as a Senior Research Associate in Early Discover Biochemistry at Genentech and is a registered Patent Agent with the United States Patent and Trademark Office.


Journal of the American Chemical Society
Dynamic Active-Site Protection by the M. Tuberculosis Protein Tyrsine Phosphatase TtpB Lid Domain

Kinetic Manifestation of Processivity during Multiple Methylations Catalyzed by SET-domain Protein Methyltransferases

Nature Structural and Molecular Biology
Mechanism of Multiple Lysine methylation by the SET domain enzyme Rubisco LSMT

Professional Coference Presentations:

2004 - Annual Meeting of the American Society for Biochemistry and Molecular Biology/8th Conference for the International Union for Biochemistry Biology, Boston, MA
2004 - 29th Congress of the Federation of European Biochemical Societies, Poland

From Megan (Spring 2004):

In Dr. Robert L. Houtz' laboratory in the Department of Horticulture, I completed 3 years of undergraduate research on functional characterization of SET domain-containing proteins using structure as a guide. I have presented my research at Posters-at-the-Capitol, the National Conference on Undergraduate Research, the American Society of Biochemistry and Molecular Biology Annual Meeting, the Federation of European Biochemical Societies International Congress, and a FASEB Summer meeting on Biological Methylation. I have also published in Nature Structural and Molecular Biology and am preparing a manuscript for the Journal of Biochemistry.

While at UK, I participated in the College of Agriculture Student Council as a senior representative, Honors Program Student Council, served as the president of the local chapter of the Phi Eta Sigma National honor society, as well as the president and floor representative of the Resident Student Government, and was an active member of Omicron Delta Kappa Leadership Society. I studied abroad in the Spring 2003 semester for an ISEP exchange at the University of Malaga, Spain. My hobbies include whitewater canoeing, snow skiing, traveling, and practicing my Spanish.

Undergraduate research has been the highlight of my college career and has helped me discover the passion I possess for scientific research and the progression of scientific knowledge. Next year, I will be attending the University of California at Berkeley for a Ph.D. in Molecular and Cellular Biology with an emphasis in Biochemistry, with full tuition and stipend. I hope to then become a Professor and researcher at a large research university, where I can participate in the progression of science and mentor young scientists.

Research Proposal: