Room 329A, Sanders-Brown Center on Aging, 800 South Limestone Street, Lexington, KY 40536-0230
Department of Molecular and Biomedical Pharmacology and Sanders-Brown Center on Aging
Blood-Brain Barrier Function in Alzheimer's Disease
The blood-brain barrier is the vasculature that separates blood from brain. The primary role of this barrier is to ensure nutrient supply to the brain and, at the same time, to protect the brain from potentially toxic xenobiotics, including therapeutic drugs. Recent studies show that brain disorders affect the blood-brain barrier, which itself may play a role in brain pathology such as Alzheimer’s disease. This is a new paradigm in the field that is not well understood.
My current research is focused on mechanisms that regulate blood-brain barrier function in Alzheimer’s disease. We develop novel therapeutic strategies to improve blood-brain barrier function to reduce memory loss and delay onset and slow progression of Alzheimer’s disease.
Hartz AM, Bauer B, Soldner EL, Wolf A, Boy S, Backhaus R, Mihaljevic I, Bogdahn U, Klunemann HH, Schuierer G, Schlachetzki F (2012) Amyloid-beta contributes to blood-brain barrier leakage in transgenic human amyloid precursor protein mice and in humans with cerebral amyloid angiopathy. Stroke 43:514-523.
Wolf A, Bauer B, Hartz AM (2012) ABC Transporters and the Alzheimer's Disease Enigma. Front Psychiatry 3:54.
Agarwal S, Hartz AM, Elmquist WF, Bauer B (2011) Breast cancer resistance protein and P-glycoprotein in brain cancer: two gatekeepers team up. Curr Pharm Des 17:2793-2802.
Shukla S, Skoumbourdis AP, Walsh MJ, Hartz AM, Fung KL, Wu CP, Gottesman MM, Bauer B, Thomas CJ, Ambudkar SV (2011) Synthesis and characterization of a BODIPY conjugate of the BCR-ABL kinase inhibitor Tasigna (nilotinib): evidence for transport of Tasigna and its fluorescent derivative by ABC drug transporters. Mol Pharm 8:1292-1302.
Hartz AM, Bauer B (2010) Regulation of ABC transporters at the blood-brain barrier: new targets for CNS therapy. Mol Interv 10:293-304.
Hartz AM, Mahringer A, Miller DS, Bauer B (2010) 17-beta-Estradiol: a powerful modulator of blood-brain barrier BCRP activity. J Cereb Blood Flow Metab 30:1742-1755.
Hartz AM, Miller DS, Bauer B (2010) Restoring blood-brain barrier P-glycoprotein reduces brain amyloid-beta in a mouse model of Alzheimer's disease. Mol Pharmacol 77:715-723.