Room 329A, Sanders-Brown Center on Aging, 800 South Limestone Street, Lexington, KY 40536-0230
Department of Molecular and Biomedical Pharmacology and Sanders-Brown Center on Aging
Blood-Brain Barrier Function in Alzheimer's Disease
The blood-brain barrier is the vasculature that separates blood from brain. The primary role of this barrier is to ensure nutrient supply to the brain and, at the same time, to protect the brain from potentially toxic xenobiotics, including therapeutic drugs. Recent studies show that brain disorders affect the blood-brain barrier, which itself may play a role in brain pathology such as Alzheimer’s disease. This is a new paradigm in the field that is not well understood.
My current research is focused on mechanisms that regulate blood-brain barrier function in Alzheimer’s disease. We develop novel therapeutic strategies to improve blood-brain barrier function to reduce memory loss and delay onset and slow progression of Alzheimer’s disease.