Room 131, Sanders-Brown Center on Aging
800 South Limestone Street
Lexington, KY 40536-0230
Molecular and Biomedical Pharmacology
Calcium signaling pathways in brain aging and aging-related diseases
Dr. Norris' work focuses on the role of Ca2+ signaling mechanisms in brain aging and neurodegenerative disease, with recent emphasis on the Ca2+/calmodulin dependent protein phosphatase, calcineurin, and its downstream targets. Most studies are conducted on the hippocampus, or hippocampal cultures using a variety of experimental approaches including: adenoviral-mediated gene delivery, electrophysiology (patch clamp and sharp electrode recordings), immunocytochemistry, and protein biochemistry. Behavioral assessment in rodents also is used to test brain-behavior relationships.
Alzheimer’s Research Forum: Chicago: NFATs, Calcineurin—Mediators of AD, PD Pathogenesis?
Alzheimer’s Research Forum: The Skinny on NFATs—Mediators of Aβ Toxicity?