Room 430, Sanders-Brown Center on Aging
800 South Limestone Street
Lexington, KY 40536-0230
Anatomy and Neurobiology, Neurology and Sanders-Brown Center on Aging
The role of the extracellular matrix in stroke
My lab is interested in the role of extracellular matrix in stroke, the third leading cause of mortality in the United States. Vascular matrix components are often very sensitive to proteolytic processing/degradation in models of focal cerebral ischemia. Often such processing will generate biologically active matrix fragments. One focus of our lab is to determine how select matrix fragments affect the neurovascular unit, the functional multicellular unit that is perturbed in stroke. Another focus of our lab is to determine what role these matrix fragments could play in neurodevelopment involving processes that are often recapitulated in response to CNS injury.
Bix GJ, Gowing EK, Clarkson AN. Perlecan domain V is neuroprotective and affords functional improvement in a photothrombotic stroke model in young and aged mice. Transl Stroke Res 4: 515-523, 2013. PMID 24323378.
Bix GJ. Perlecan domain V therapy for stroke: a beacon of hope? ACS Chem Neurosci 4: 370-374, 2013. PMID 23509972.
Clarke DN, Al Ahmad A, Lee B, Parham C, Auckland L, Fertala A, Kahle M, Shaw CS, Roberts J, Bix GJ. Perlecan Domain V induces VEGf secretion in brain endothelial cells through integrin alpha5beta1 and ERK-dependent signaling pathways. PLoS One 7: e45257, 2012. PMID 23028886.
Grupke S, Hall J, Dobbs M, Bix GJ, Fraser JF. Understanding history, and not repeating it. Neuroprotection for acute ischemic stroke: from review to preview. Clin Neurol Neurosurg 129: 1-9, 2015. PMID 25497127.
Guell K, Bix GJ. Brain endothelial cell specific integrins and ischemic stroke. Expert Rev Neurother 14: 1287-1292, 2014. PMID 25262658.
Jullienne A, Roberts JM, Pop V, Paul Murphy M, Head E, Bix GJ, Badaut J. Juvenile traumatic brain injury induces long-term perivascular matrix changes alongside amyloid-beta accumulation. J Cereb Blood Flow Metab 34: 1637-1645, 2014. PMID 25052558.
Kahle MP, Bix GJ. Neuronal restoration following ischemic stroke: influences, barriers, and therapeutic potential. Neurorehabil Neural Repair 27: 469-478, 2013. PMID 23392917.
Kahle MP, Bix GJ. Successfully Climbing the "STAIRs": Surmounting Failed Translation of Experimental Ischemic Stroke Treatments. Stroke Res Treat 2012: 374098, 2012. PMID 23326759.
Kahle MP, Lee B, Pourmohamad T, Cunningham A, Su H, Kim H, Chen Y, McCulloch CE, Barbaro NM, Lawton MT, Young WL, Bix GJ. Perlecan domain V is upregulated in human brain arteriovenous malformation and could mediate the vascular endothelial growth factor effect in lesional tissue. Neuroreport 23: 627-630, 2012. PMID 22643235.
Roberts J, Kahle MP, Bix GJ. Perlecan and the blood-brain barrier: beneficial proteolysis? Front Pharmacol 3: 155, 2012. PMID 22936915.
Saini MG, Bix GJ. Oxygen-glucose deprivation (OGD) and interleukin-1 (IL-1) differentially modulate cathepsin B/L mediated generation of neuroprotective perlecan LG3 by neurons. Brain Res 1438: 65-74, 2012. PMID 22244880.
Steelman SM, Hein TW, Gorman A, Bix GJ. Effects of histidine-rich glycoprotein on cerebral blood vessels. J Cereb Blood Flow Metab 33: 1373-1375, 2013. PMID 23801240.