Room 135, Sanders-Brown Center On Aging
800 South Limestone Street
Lexington, KY 40536-0230
Chemistry and Sanders-Brown Center on Aging
(1) the role of oxidative stress, particularly DNA oxidation, in the pathogenesis of neuron degeneration in Alzheimer’s disease brain; (2) the role of disruption of zinc homeostasis in AD; and (3) the application of quantitative proteomics to identify differences in protein expression in mitochondria isolated from control subjects, early AD subjects, subjects with Mild Cognitive Impairment and late-stage AD subjects.