Mark A. Lovell, Ph.D.
Position
Professor
Address
Address
Room 135, Sanders-Brown Center On Aging
800 South Limestone Street
Lexington, KY 40536-0230
Departmental Affiliations
Chemistry
In the Lab
the role of oxidative stress, particularly DNA oxidation, in the pathogenesis of neuron degeneration in Alzheimer’s disease brain; (2) the role of disruption of zinc homeostasis in AD; and (3) the application of quantitative proteomics to identify differences in protein expression in mitochondria isolated from control subjects, early AD subjects, subjects with Mild Cognitive Impairment and late-stage AD subjects.
Recent Publications
C.D. Smith, H. Chebrolu, A.H. Andersen, D.A. Powell, M.A. Lovell, S. Xiong, and B.T. Gold, “White Matter Diffusion Alterations in Normal Women at Risk of Alzheimer’s Disease”,Neurobiol. Aging, In Press, (2008).
M. A. Lovell, B. C. Lynn, S. Xiong, J. F. Quinn, J. Kaye and W. R. Markesbery, “An Aberrant Protein Complex as a Biomarker of Alzheimer’s Disease”,Neurology,70:2212-2218, (2008).
M. A. Lovell, B. C. Lynn, S. Xiong, J. F. Quinn, J. Kaye and W. R. Markesbery, “An Aberrant Protein Complex as a Biomarker of Alzheimer’s Disease”, Neurology,70:2212-2218, (2008).
C. X. Shao, J. Wang, W. R. Markesbery and M. A. Lovell, “Decreased Ogg1 Based Excision Repair in Amnestic Mild Cognitive Impairment”,Free Radic. Biol. Med.45:813-819,(2008).
J. Dong, J.D. Robertson, W.R. Markesbery and M.A. Lovell, “Alterations in serum zinc in the progression of Alzheimer’s disease”,J. Alzheimer’s Disease, 15:443-450, (2008).
J. Dong, J.D. Robertson, W.R. Markesbery and M.A. Lovell, “Alterations in serum zinc in the progression of Alzheimer’s disease”,J. Alzheimer’s Disease, 15:443-450, (2008).
M. A. Lovell and W. R. Markesbery, “Oxidative Modification of RNA in Mild Cognitive Impairment”,Neurobiol. Dis., 29:169-175, (2008).
Lovell MA, Markesbery WR. Oxidative DNA damage in mild cognitive impairment and late-stage Alzheimer's disease. Nucleic Acids Res 35: 7497-7504, 2007.
G. Mao, Y. Zhang, F. Yuan, B. B. Zhu, M. A. Lovell, M. P. Lee, W. R. Markesbery, L. Gu and G. M. Li, “Identification of an OGG1 Mutation Inactivating 8-oxo-guanine DNA glycosylase Activity in Patients with Alzheimer’s Disease”,Nuc. Acids Res.,35:2759-2766, (2007).
Markesbery WR, Lovell MA. Damage to lipids, proteins, DNA, and RNA in mild cognitive impairment. Arch Neurol 64: 954-956, 2007.
Mehta SG, Watts GD, Adamson JL, Hutton M, Umberger G, Xiong S, Ramdeen S, Lovell MA,Kimonis VE, Smith CD. APOE is a potential modifier gene in an autosomal dominant form of frontotemporal dementia (IBMPFD). Genet Med 9: 9-13, 2007.
Xiong S, Markesbery WR, Shao C, Lovell MA. Seleno-L-methionine protects against beta-amyloid and iron/hydrogen peroxide-mediated neuron death. Antioxid Redox Signal 9: 457-467, 2007.