Richard J. Kryscio, Ph.D.
Position
Professor
Address
Address
Room 230, Sanders-Brown Center On Aging
800 South Limestone Street
Lexington, KY 40536-0230
Departmental Affiliations
Statistics and Chair, Biostatistics
Research Focus
(1) longitudinal data analysis with a focus in subareas related to Markov transition models, shared random effects, and missing data; (2) prevention trials in Alzheimer’s disease; (3) design and analysis of clinical trials with emphasis on ALS, PD, and traumatic brain injury; (4) screening for early detection of ovarian cancer; and (5) estimating relative risk on the line using nearest neighbor statistics.
In the Lab
Erin Abner, M.S.
Yushun Lin, M.S.
Liou Xu, Ph.D.
Josh Stalion
Lab Mission
To provide expert advice on study design and data analysis to all investigators in the Center on Aging and related programs in aging. To conduct research on statistical methodology relevant to Alzheimer’s disease, aging, the neurosciences, and ovarian cancer.
Recent Publications
Nelson PT, Abner EL, Schmitt FA, Kryscio RJ, Jicha GA, Smith CD, Davis DG, Poduska JW, Patel E, Mendiondo MS, Markesbery WR. Modeling the association between 43 different clinical and pathological variables and the severity of cognitive impairment in a large autopsy cohort of elderly persons.Brain Pathol. 2010 Jan;20(1):66-79.
Yu L, Tyas SL, Snowdon DA, Kryscio RJ. Effects of ignoring baseline on modeling transitions from intact cognition to dementiaComput Stat Data Anal. 2009; 53(9):3334-3343.
Pavlik, E.J., Saunders, B.A., Doran,S., McHugh, K.W., Ueland,F.R., DeSimone, C.P., DePriest, P.D., Ware, R.A., Kryscio, R.J., van Nagell, J.R. The search for meaning- Symptoms and transvaginal sonography screening for ovarian cancer: predicting malignancy. Cancer 2009: 115(16): 3689-3698.
Nelson, P.T., Kryscio, R.J., Jicha, G.A., Abner, E. L., Schmitt, F.A., Xu, L.O., Cooper, G., Smith,C.D., Markesbery,W.R. Relative preservation of MMSE scores in autopsy proven dementia with Lewy bodies. Neurology 73(14): 1127-1133, 2009.
Sparks DL, Kryscio RJ, Connor DJ, Sabbagh MN, Sparks LM, Lin Y, Liebsack C. Cholesterol and cognitive performance in normal controls and the influence of elective statin use after conversion to mild cognitive impairment: results in a clinical trial cohort. Neurodegener Dis. 2010;7(1-3):183-6.
Stein PS, Kryscio RJ, Desrosiers M, Donegan SJ, Gibbs MB. Tooth loss, apolipoprotein E, and decline in delayed word recall.J Dent Res. 2010; 89(5):473-7.
Wang CC, Yepes LC, Danaher RJ, Berger JR, Mootoor Y, Kryscio RJ, Miller CS. Low prevalence of varicella zoster virus and herpes simplex virus type 2 in saliva from human immunodeficiency virus infected persons in the era of highly active antiretroviral therapy.Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010; 109(2):232-7.
Nelson PT, Schmitt FA, Jicha GA, Kryscio RJ, Abner EL, Smith CD, Van Eldik LJ, Markesbery WR. Association between male gender and cortical Lewy body pathology in large autopsy series.J Neurol. 2010; 257(11):1875-81
Murphy MP, Morales J, Beckett TL, Astarita G, Piomelli D, Weidner A, Studzinski CM, Dowling AL, Wang X, Levine H 3rd, Kryscio RJ, Lin Y, Barrett E, Head E. Changes in cognition and amlyoid-β processing with long term cholesterol reduction using atorvastatin in aged dogs.J Alzheimers Dis. 2010;22(1):135-50.
Mirrielees J, Crofford LJ, Lin Y, Kryscio RJ, Dawson Iii DR, Ebersole JL, Miller CS. Rheumatoid arthritis and salivary biomarkers of periodontal disease.J Clin Periodontol. 2010; 37(12):1068-74.
Reneer DV, Hisel RD, Hoffman JM, Kryscio RJ, Lusk BT, Geddes JW. A multi-mode shock tube for investigation of blast-induced traumatic brain injury.J Neurotrauma. 2011 28(1): 95-104.
Yu, L., Griffith, W.S., Tyas, S.L., Snowdon, D.A., Kryscio, R.J. A nonstationary Markov transition model for computing the relative risk of dementia before death. Statistics in Medicine, 2010; 29: 639-648.
Abner EL, Schmitt FA, Mendiondo MS, Marcum JL, Kryscio RJ. Vitamin E and All-cause mortality: a meta analysis. Curr.Aging Science 2011: Epub ahead of print