Room 101, Sanders-Brown Center On Aging 800 South Limestone Street Lexington, KY 40536-0230
Anatomy and Neurobiology, Neurology, Psychology, SCoBIRC and Sanders-Brown Center on Aging Endowed Chair, Mansbach Chair in Alzheimer’s Disease
Changes in brain connectivity as a function of both normal aging and Alzheimer’s disease. Using morphological studies, it is possible to investigate changes in synaptic connections in both limbic and association areas of the brain that reflect alterations in cognitive function. The laboratory uses short postmortem human tissue to try and understand the mechanisms underlying the loss of synaptic connections in individuals with mild cognitive impairment and early Alzheimer’s disease. Another portion of the laboratory employs animal models of traumatic brain injury to study how normal aging affects the recovery mechanism following neural trauma. These studies are multi-faceted and study not only morphological but also behavioral and neurochemical alterations.
To gain a better understanding of normal human aging and changes occurring in mild cognitive impairment leading to the development of pharmacologic therapy to improve the quality of life.