The mission of the UK-ADC Clinical Core is to provide thoroughly evaluated, longitudinally followed normal control subjects and Alzheimer’s disease (AD) and other non-AD dementing disorders patients for research studies at UK and other ADCs and institutions studying AD. All longitudinally followed subjects have consented to brain donation, continuing our Center’s emphasis on clinical-pathological correlation.
- Clinical Studies for Volunteers and Patients
- Kentucky Neuroscience Institute Memory Disorders Clinic: UK-ADC neurologists offer initial evaluations for memory loss of patients with late-life cognitive disorders, e.g., AD and vascular dementia. Following evaluation, patients may be asked to participate in our Sanders-Brown Center on Aging Clinic studies.
- Telemedicine Cognitive Clinic is for patients who live in remote areas of Kentucky or surrounding states. The use of a videoconferencing system allows patient and doctor to see and talk with each other as if they were in the same room.
- Sanders-Brown Center on Aging Clinic The UK-ADC Clinical Core is dedicated to the study of normal brain aging and transitions across the spectrum of cognitive impairment (normal/ preclinical AD/ MCI/ dementia). Our normal brain aging study follows a research control group of 500 initially cognitively normal, healthy aged subjects (Sanders-Brown Healthy Brain Aging Volunteers). The core provides an integrated program of diagnosis, treatment and research for those with Alzheimer’s disease or a related disorder and longitudinally follows 200-300 well-characterized patients who have transitioned from normal, preclinical AD or MCI, to AD or other dementias. All study participants have consented to brain donation, continuing our Center’s emphasis on clinical-pathological correlation.
- The Minority Gateway Satellite Clinic for African Americans at UK Polk-Dalton evaluates and longitudinally follows a cohort of cognitively normal and approximately 100 impaired subjects.
- Provides an environment for translational research to support therapeutic development for AD and other dementing disorders by offering clinical trials and other investigator-initiated projects.
- Participates in ADCS and Pharmaceutical-Sponsored Clinical Trials (Hyperlink to UK-ADC/Participate in a Study/CLINICAL TRIALs)
- Participates in NIH/NIA major initiatives such as NACC, ADCS, ADNI/ADNI-GO/ADNI II, NCRAD, and GWAS.
- Provides data for the ADC database and serum, plasma, buffy coats, and CSF from normal controls, MCI patients, early, mid, and late stage AD patients, and non-AD dementias for use by investigators, ADC pilot studies, two UK AD program project grants, multiple AD R01 grants, other research projects at UK, and other national and international investigators in neurodegenerative diseases and normal aging. For investigators, see Biostatistics and Data Management Core for data requests.
- Maintains a Community Registry Database of participants aged 65 and older from the local geographic area who responded to a letter and questionnaire. This database is used to recruit participants for our longitudinal cohorts and is popular with local aging researchers who require older participants with particular demographic profiles.
Core Leader - Gregory Jicha, MD, PhD
AddressRoom 233, Sanders-Brown Center on Aging
800 S. Limestone Street
Lexington KY 40536-0230
Phone Number(859) 257-1412 x255
Clinical Core Primary Phone: (859) 323-5550
- Frederick Schmitt, PhD
- Charles D. Smith, MD
- Allison Caban-Holt, PhD
|Clinic Coordinator||Jeffrey Howe, MS|
|Research Volunteer Coordinator||Katherine Grossman, MS|
|Research Admin Coordinators/Clinical||Diane Spencer|
|Clinical Research Assistants||
Marie Smart, LSW
Robin Hamon, MSW
|Administrative Assistant||Jacqueline Towner|
|Research Administrative Coordinator||Sarah Tarrant|
|Clinical Trial Coordinators||Heather Nichols|