Room 101, Sanders-Brown Center On Aging
800 South Limestone Street
Lexington, KY 40536-0230
Department of Neurology and Sanders-Brown Center on Aging
Vascular disease affecting the nervous system in aging adults. As a clinician performing human-oriented research in stroke, he studies acute stroke therapy (neuroprotective drugs and novel thrombolytic agents), alternative approaches to prevention and vascular dementia (vitamin therapy, drugs designed to overcome insulin resistance), and treatment of cerebral amyloid angiopathy causing brain hemorrhage (homotaurine). His laboratory in the Sanders-Brown Center on Aging is funded by the NIH to study the role of tumor necrosis factor-alpha in an animal model of cerebral ischemic injury.
Pettigrew LC, Kindy MS, Scheff S, Springer JE, Kryscio RJ, Li Y, Grass DS. Focal cerebral ischemia in the TNFa-transgenic rat. J Neuroinflammation 2008;5:47 (e-publication).
Pettigrew LC, Bang H, Chambless LE, Howard VJ, Toole JF. Assessment of pre- and post-methionine load homocysteine for prediction of recurrent stroke and myocardial infarction in the Vitamin Intervention for stroke Prevention trial. Atherosclerosis 2008;200:345-349.
Espinosa PS, Pettigrew LC, Berger JR. Hereditary hemorrhagic telangiectasia and spinal cord infarct: case report with a review of the neurological complications of HHT. Clin Neurol Neurosurg 2008;110:484-492.
Vaishnav AG, Pettigrew LC, Ryan S. Telephonic guidance of systemic thrombolysis in acute ischemic stroke: safety outcome in rural hospitals. Clin Neurol Neurosurg 2008;110:451-4.
Blonder LX, Langer SL, Pettigrew LC, Garrity TF. The effects of stroke disability on spousal caregivers. NeuroRehabilitation 22: 85-92, 2007.
Korde AS, Pettigrew LC, Craddock SD, Pocernich CB, Waldmeier PC, Maragos WF. Protective effects of NIM811 in transient focal cerebral ischemia suggest involvement of the mitochondrial permeability transition. J Neurotrauma 24: 895-908, 2007.
Pettigrew LC, Bang H, Chambless LE, Howard VJ, Toole JF. Assessment of pre- and post-methionine load homocysteine for prediction of recurrent stroke and coronary artery disease in the Vitamin Intervention for Stroke Prevention Trial. Atherosclerosis 2007.
Ishibashi H, Pettigrew LC, Funakoshi Y, Hiramatsu M. Pharmacokinetics of arundic acid, an astrocyte modulating agent, in acute ischemic stroke. J Clin Pharmacol 47: 445-452, 2007.