The Core serves as a data collection and analytic hub for the UK-ADC by:
One of the primary objectives of this core is to maintain a centralized database of all information collected by the ADC cores, pilot projects, and AD and aging research studies. Activities that support this objective include:
The core also provides expertise on experimental design and analysis to ADC cores, pilot projects, and other aging and AD research initiatives. Activities that support this objective include:
This core contributes to the literature with innovative studies on statistical methodology in AD research and participates in the training of graduate students, postdoctoral researchers, and young investigators.
To read more about the Biostatistics Core Studies go here.
The BDMC is investigating risk factors associated with the UK-ADC transition/translation diagram (figure below left) by making the intervening states transient and accounting for the competing risk of death (figure below right) taken from Salazar et al., et al. Stat Med. 2007;26:568-580.
There is a wealth of information available on our longitudinal cohort. For example, our centralized database consists of clinical data on 4,765 subjects. This includes 1,000 subjects enrolled as cognitively intact at entry having 7,009 person years of follow-up and of these 266 have come to autopsy after 2,321 person years of follow-up. This is a critical resource for investigators, whose requests for snapshots of the centralized database have risen to an average of 7 requests per month in the past year.
Link to Biospecimen, Data or Clinic Request for more information
AddressRoom 230, Sanders-Brown Center on Aging
800 South Limestone Street
Lexington, KY 40536-0230
Phone Number(859) 257-4064
Fax Number(859) 257-4665
|Data Manager||Erin Abner, MA|