Recent Publications

  • Abisambra JF, Scheff S (2014) Brain injury in the context of tauopathies. J Alzheimers Dis 40:495-518.
  • Abner EL, Nelson PT, Schmitt FA, Browning SR, Fardo DW, Wan L, Jicha GA, Cooper GE, Smith CD, Caban-Holt AM, Van Eldik LJ, Kryscio RJ (2014) Self-reported head injury and risk of late-life impairment and AD pathology in an AD center cohort. Dement Geriatr Cogn Disord 37:294-306.
  • Bachstetter AD, Watterson DM, Van Eldik LJ (2014) Target Engagement Analysis and Link to Pharmacodynamic Endpoint for a Novel Class of CNS-penetrant and Efficacious p38alpha MAPK Inhibitors. J Neuroimmune Pharmacol.
  • Brenowitz WD, Monsell SE, Schmitt FA, Kukull WA, Nelson PT (2014) Hippocampal sclerosis of aging is a key Alzheimer's disease mimic: clinical-pathologic correlations and comparisons with both alzheimer's disease and non-tauopathic frontotemporal lobar degeneration. J Alzheimers Dis 39:691-702.
  • Butterfield DA (2014) The 2013 SFRBM discovery award: Selected discoveries from the butterfield laboratory of oxidative stress and its sequela in brain in cognitive disorders exemplified by Alzheimer disease and chemotherapy induced cognitive impairment. Free Radic Biol Med 74c:157-174.
  • Butterfield DA, Di Domenico F, Barone E (2014) Elevated risk of type 2 diabetes for development of Alzheimer disease: A key role for oxidative stress in brain. Biochim Biophys Acta 1842:1693-1706.
  • Butterfield DA, Gu L, Di Domenico F, Robinson RA (2014) Mass spectrometry and redox proteomics: applications in disease. Mass Spectrom Rev 33:277-301.
  • Davis PR, Head E (2014) Prevention approaches in a preclinical canine model of Alzheimer's disease: benefits and challenges. Front Pharmacol 5:47.
  • Di Domenico F, Pupo G, Tramutola A, Giorgi A, Schinina ME, Coccia R, Head E, Butterfield DA, Perluigi M (2014) Redox proteomics analysis of HNE-modified proteins in Down syndrome brain: clues for understanding the development of Alzheimer disease. Free Radic Biol Med 71:270-280.
  • Farr SA, Ripley JL, Sultana R, Zhang Z, Niehoff ML, Platt TL, Murphy MP, Morley JE, Kumar V, Butterfield DA (2014) Antisense oligonucleotide against GSK-3beta in brain of SAMP8 mice improves learning and memory and decreases oxidative stress: Involvement of transcription factor Nrf2 and implications for Alzheimer disease. Free Radic Biol Med 67:387-395.
  • Forster S, Welleford AS, Triplett JC, Sultana R, Schmitz B, Butterfield DA (2014) Increased O-GlcNAc levels correlate with decreased O-GlcNAcase levels in Alzheimer disease brain. Biochim Biophys Acta 1842:1333-1339.
  • Gold BT, Zhu Z, Brown CA, Andersen AH, LaDu MJ, Tai L, Jicha GA, Kryscio RJ, Estus S, Nelson PT, Scheff SW, Abner E, Schmitt FA, Van Eldik LJ, Smith CD (2014) White matter integrity is associated with cerebrospinal fluid markers of Alzheimer's disease in normal adults. Neurobiol Aging 35:2263-2271.
  • Greenberg RN, Gurtman A, Frenck RW, Strout C, Jansen KU, Trammel J, Scott DA, Emini EA, Gruber WC, Schmoele-Thoma B (2014) Sequential administration of 13-valent pneumococcal conjugate vaccine and 23-valent pneumococcal polysaccharide vaccine in pneumococcal vaccine-naive adults 60-64 years of age. Vaccine 32:2364-2374.
  • Hallgren J, Pietrzak M, Rempala G, Nelson PT, Hetman M (2014) Neurodegeneration-associated instability of ribosomal DNA. Biochim Biophys Acta 1842:860-868.
  • Holler CJ, Davis PR, Beckett TL, Platt TL, Webb RL, Head E, Murphy MP (2014) Bridging Integrator 1 (BIN1) Protein Expression Increases in the Alzheimer's Disease Brain and Correlates with Neurofibrillary Tangle Pathology. J Alzheimers Dis.
  • Jullienne A, Roberts JM, Pop V, Paul Murphy M, Head E, Bix GJ, Badaut J (2014) Juvenile traumatic brain injury induces long-term perivascular matrix changes alongside amyloid-beta accumulation. J Cereb Blood Flow Metab.
  • Kasarskis EJ, Mendiondo MS, Matthews DE, Mitsumoto H, Tandan R, Simmons Z, Bromberg MB, Kryscio RJ (2014) Estimating daily energy expenditure in individuals with amyotrophic lateral sclerosis. Am J Clin Nutr 99:792-803.
  • Kryscio RJ (2014) Secondary Prevention Trials in Alzheimer Disease: The Challenge of Identifying a Meaningful End Point. JAMA Neurol.
  • Lin AL, Coman D, Jiang L, Rothman DL, Hyder F (2014) Caloric restriction impedes age-related decline of mitochondrial function and neuronal activity. J Cereb Blood Flow Metab.
  • Marcelo A, Bix G (2014) Investigating the role of perlecan domain V in post-ischemic cerebral angiogenesis. Methods Mol Biol 1135:331-341.
  • Marcelo A, Bix G (2014) The potential role of perlecan domain V as novel therapy in vascular dementia. Metab Brain Dis.
  • Martin SB, Dowling AL, Lianekhammy J, Lott IT, Doran E, Murphy MP, Beckett TL, Schmitt FA, Head E (2014) Synaptophysin and Synaptojanin-1 in Down Syndrome are Differentially Affected by Alzheimer's Disease. J Alzheimers Dis.
  • Mathews M, Abner E, Kryscio R, Jicha G, Cooper G, Smith C, Caban-Holt A, Schmitt FA (2014) Diagnostic accuracy and practice effects in the National Alzheimer's Coordinating Center Uniform Data Set neuropsychological battery. Alzheimers Dement.
  • Matveev SV, Spielmann HP, Metts BM, Chen J, Onono F, Zhu H, Scheff SW, Walker LC, LeVine H, 3rd (2014) A distinct subfraction of Abeta is responsible for the high-affinity Pittsburgh compound B-binding site in Alzheimer's disease brain. J Neurochem.
  • McBride JC, Zhao X, Munro NB, Smith CD, Jicha GA, Hively L, Broster LS, Schmitt FA, Kryscio RJ, Jiang Y (2014) Spectral and complexity analysis of scalp EEG characteristics for mild cognitive impairment and early Alzheimer's disease. Comput Methods Programs Biomed 114:153-163.
  • Moga DC, Abner EL, Brouwer ES (2014) Dementia and "Obesity Paradox": Is This for Real or Are We Missing Something? An Epidemiologist's Perspective. J Am Med Dir Assoc.
  • Nelson PT, Estus S, Abner EL, Parikh I, Malik M, Neltner JH, Ighodaro E, Wang WX, Wilfred BR, Wang LS, Kukull WA, Nandakumar K, Farman ML, Poon WW, Corrada MM, Kawas CH, Cribbs DH, Bennett DA, Schneider JA, Larson EB, Crane PK, Valladares O, Schmitt FA, Kryscio RJ, Jicha GA, Smith CD, Scheff SW, Sonnen JA, Haines JL, Pericak-Vance MA, Mayeux R, Farrer LA, Van Eldik LJ, Horbinski C, Green RC, Gearing M, Poon LW, Kramer PL, Woltjer RL, Montine TJ, Partch AB, Rajic AJ, Richmire K, Monsell SE, Schellenberg GD, Fardo DW (2014) ABCC9 gene polymorphism is associated with hippocampal sclerosis of aging pathology. Acta Neuropathol 127:825-843.
  • Neltner JH, Abner EL, Baker S, Schmitt FA, Kryscio RJ, Jicha GA, Smith CD, Hammack E, Kukull WA, Brenowitz WD, Van Eldik LJ, Nelson PT (2014) Arteriolosclerosis that affects multiple brain regions is linked to hippocampal sclerosis of ageing. Brain 137:255-267.
  • Niedowicz DM, Reeves VL, Platt TL, Kohler K, Beckett TL, Powell DK, Lee TL, Sexton TR, Song ES, Brewer LD, Latimer CS, Kraner SD, Larson KL, Ozcan S, Norris CM, Hersh LB, Porter NM, Wilcock DM, Murphy MP (2014) Obesity and diabetes cause cognitive dysfunction in the absence of accelerated beta-amyloid deposition in a novel murine model of mixed or vascular dementia. Acta Neuropathol Commun 2:64.
  • Parikh I, Fardo DW, Estus S (2014) Genetics of PICALM expression and Alzheimer's disease. PLoS One 9:e91242.
  • Perez SE, He B, Nadeem M, Wuu J, Scheff SW, Abrahamson EE, Ikonomovic MD, Mufson EJ (2014) Resilience of Precuneus Neurotrophic Signaling Pathways Despite Amyloid Pathology in Prodromal Alzheimer's Disease. Biol Psychiatry.
  • Perluigi M, Pupo G, Tramutola A, Cini C, Coccia R, Barone E, Head E, Butterfield DA, Di Domenico F (2014) Neuropathological role of PI3K/Akt/mTOR axis in Down syndrome brain. Biochim Biophys Acta 1842:1144-1153.
  • Perluigi M, Swomley AM, Butterfield DA (2014) Redox proteomics and the dynamic molecular landscape of the aging brain. Ageing Res Rev 13:75-89.
  • Powell D, Caban-Holt A, Jicha G, Robertson W, Davis R, Gold BT, Schmitt FA, Head E (2014) Frontal white matter integrity in adults with Down syndrome with and without dementia. Neurobiol Aging 35:1562-1569.
  • Qosa H, LeVine H, 3rd, Keller JN, Kaddoumi A (2014) Mixed oligomers and monomeric amyloid-beta disrupts endothelial cells integrity and reduces monomeric amyloid-beta transport across hCMEC/D3 cell line as an in vitro blood-brain barrier model. Biochim Biophys Acta 1842:1806-1815.
  • Rannikmae K, Kalaria RN, Greenberg SM, Chui HC, Schmitt FA, Samarasekera N, Al-Shahi Salman R, Sudlow CL (2014) APOE associations with severe CAA-associated vasculopathic changes: collaborative meta-analysis. J Neurol Neurosurg Psychiatry 85:300-305.
  • Rowe RK, Striz M, Bachstetter AD, Van Eldik LJ, Donohue KD, O'Hara BF, Lifshitz J (2014) Diffuse brain injury induces acute post-traumatic sleep. PLoS One 9:e82507.
  • Scheff SW, Neltner JH, Nelson PT (2014) Is synaptic loss a unique hallmark of Alzheimer's disease? Biochem Pharmacol 88:517-528.
  • Sudduth TL, Weekman EM, Brothers HM, Braun K, Wilcock DM (2014) beta-amyloid deposition is shifted to the vasculature and memory impairment is exacerbated when hyperhomocysteinemia is induced in APP/PS1 transgenic mice. Alzheimers Res Ther 6:32.
  • Wang WX, Danaher RJ, Miller CS, Berger JR, Nubia VG, Wilfred BS, Neltner JH, Norris CM, Nelson PT (2014) Expression of miR-15/107 family microRNAs in human tissues and cultured rat brain cells. Genomics Proteomics Bioinformatics 12:19-30.
  • Webster SJ, Bachstetter AD, Nelson PT, Schmitt FA, Van Eldik LJ (2014) Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models. Front Genet 5:88.
  • Xing B, Bachstetter AD, Van Eldik LJ (2014) Inhibition of Neuronal p38alpha, but not p38beta MAPK, Provides Neuroprotection Against Three Different Neurotoxic Insults. J Mol Neurosci.
  • Zhao Y, Miriyala S, Miao L, Mitov M, Schnell D, Dhar SK, Cai J, Klein JB, Sultana R, Butterfield DA, Vore M, Batinic-Haberle I, Bondada S, St Clair DK (2014) Redox proteomic identification of HNE-bound mitochondrial proteins in cardiac tissues reveals a systemic effect on energy metabolism after doxorubicin treatment. Free Radic Biol Med 72:55-65
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  • Amtul Z, Park JW, Murphy MP, Siddiqui RA, Choudhary MI (2013) Dietary lipids and Alzheimer's disease. Curr Alzheimer Res 10:542-548.
  • Ansari MA, Roberts KN, Scheff S (2013) Dose and time dependent neuroprotective effects of Pycnogenol following traumatic brain injury. J Neurotrauma.
  • Bachstetter AD, Rowe RK, Kaneko M, Goulding D, Lifshitz J, Van Eldik LJ (2013) The p38alpha MAPK regulates microglial responsiveness to diffuse traumatic brain injury. J Neurosci 33:6143-6153.
  • Bag S, Ghosh S, Tulsan R, Sood A, Zhou W, Schifone C, Foster M, LeVine H, 3rd, Torok B, Torok M (2013) Design, synthesis and biological activity of multifunctional alpha,beta-unsaturated carbonyl scaffolds for Alzheimer's disease. Bioorg Med Chem Lett 23:2614-2618.
  • Bix GJ (2013) Perlecan domain V therapy for stroke: a beacon of hope? ACS Chem Neurosci 4:370-374.
  • Carty N, Nash KR, Brownlow M, Cruite D, Wilcock D, Selenica ML, Lee DC, Gordon MN, Morgan D (2013) Intracranial injection of AAV expressing NEP but not IDE reduces amyloid pathology in APP+PS1 transgenic mice. PLoS One 8:e59626.
  • Di Domenico F, Coccia R, Cocciolo A, Murphy MP, Cenini G, Head E, Butterfield DA, Giorgi A, Schinina ME, Mancuso C, Cini C, Perluigi M (2013) Impairment of proteostasis network in Down syndrome prior to the development of Alzheimer's disease neuropathology: Redox proteomics analysis of human brain. Biochim Biophys Acta 1832:1249-1259.
  • Gold BT, Kim C, Johnson NF, Kryscio RJ, Smith CD (2013) Lifelong bilingualism maintains neural efficiency for cognitive control in aging. J Neurosci 33:387-396.
  • Head E (2013) A canine model of human aging and Alzheimer's disease. Biochim Biophys Acta 1832:1384-1389.
  • Hebert SS, Wang WX, Zhu Q, Nelson PT (2013) A study of small RNAs from cerebral neocortex of pathology-verified Alzheimer's disease, dementia with lewy bodies, hippocampal sclerosis, frontotemporal lobar dementia, and non-demented human controls. J Alzheimers Dis 35:335-348.
  • Jicha GA, Rentz DM (2013) Cognitive and brain reserve and the diagnosis and treatment of preclinical Alzheimer disease. Neurology 80:1180-1181.
  • Kahle MP, Bix GJ (2013) Neuronal restoration following ischemic stroke: influences, barriers, and therapeutic potential. Neurorehabil Neural Repair 27:469-478.
  • Kryscio RJ, Abner EL, Lin Y, Cooper GE, Fardo DW, Jicha GA, Nelson PT, Smith CD, Van Eldik LJ, Wan L, Schmitt FA (2013) Adjusting for mortality when identifying risk factors for transitions to mild cognitive impairment and dementia. J Alzheimers Dis 35:823-832.
  • McBride J, Zhao X, Munro N, Smith C, Jicha G, Jiang Y (2013) Resting EEG discrimination of early stage Alzheimer's disease from normal aging using inter-channel coherence network graphs. Ann Biomed Eng 41:1233-1242.
  • Murphy MP (2013) Special issue: Animal models of disease. Biochim Biophys Acta 1832:1361.
  • Nelson PT, Pious NM, Jicha GA, Wilcock DM, Fardo DW, Estus S, Rebeck GW (2013) APOE-[Latin Small Letter Open E]2 and APOE-[Latin Small Letter Open E]4 Correlate With Increased Amyloid Accumulation in Cerebral Vasculature. J Neuropathol Exp Neurol.
  • Nicholson AM, Baker MC, Finch NA, Rutherford NJ, Wider C, Graff-Radford NR, Nelson PT, Clark HB, Wszolek ZK, Dickson DW, Knopman DS, Rademakers R (2013) CSF1R mutations link POLD and HDLS as a single disease entity. Neurology 80:1033-1040.
  • Niedowicz DM, Studzinski CM, Weidner AM, Platt TL, Kingry KN, Beckett TL, Bruce-Keller AJ, Keller JN, Murphy MP (2013) Leptin regulates amyloid beta production via the gamma-secretase complex. Biochim Biophys Acta 1832:439-444.
  • Platt TL, Reeves VL, Murphy MP (2013) Transgenic models of Alzheimer's disease: Better utilization of existing models through viral transgenesis. Biochim Biophys Acta 1832:1437-1448.
  • Pop V, Sorensen DW, Kamper JE, Ajao DO, Murphy MP, Head E, Hartman RE, Badaut J (2013) Early brain injury alters the blood-brain barrier phenotype in parallel with beta-amyloid and cognitive changes in adulthood. J Cereb Blood Flow Metab 33:205-214.
  • Rinker B, Fink BF, Stoker AR, Milan ME, Nelson PT (2013) Calcium channel blockers reduce the effects of cigarette smoking on peripheral nerve ischemia/reperfusion injury. Ann Plast Surg 70:222-226.
  • Roher AE, Cribbs DH, Kim RC, Maarouf CL, Whiteside CM, Kokjohn TA, Daugs ID, Head E, Liebsack C, Serrano G, Belden C, Sabbagh MN, Beach TG (2013) Bapineuzumab alters abeta composition: implications for the amyloid cascade hypothesis and anti-amyloid immunotherapy. PLoS One 8:e59735.
  • Sama DM, Norris CM (2013) Calcium dysregulation and neuroinflammation: Discrete and integrated mechanisms for age-related synaptic dysfunction. Ageing Res Rev.
  • Scheff SW, Ansari MA, Roberts KN (2013) Neuroprotective effect of Pycnogenol(R) following traumatic brain injury. Exp Neurol 239:183-191.
  • Scheff SW, Price DA, Schmitt FA, Roberts KN, Ikonomovic MD, Mufson EJ (2013) Synapse stability in the precuneus early in the progression of Alzheimer's disease. J Alzheimers Dis 35:599-609.
  • Schnieders T, Danner DD, McGuire C, Reynolds F, Abner E (2013) Incentives and Barriers to Research Participation and Brain Donation Among African Americans. Am J Alzheimers Dis Other Demen.
  • Sudduth TL, Greenstein A, Wilcock DM (2013) Intracranial Injection of Gammagard, a Human IVIg, Modulates the Inflammatory Response of the Brain and Lowers Abeta in APP/PS1 Mice Along a Different Time Course than Anti-Abeta Antibodies. J Neurosci 33:9684-9692.
  • Sudduth TL, Powell DK, Smith CD, Greenstein A, Wilcock DM (2013) Induction of hyperhomocysteinemia models vascular dementia by induction of cerebral microhemorrhages and neuroinflammation. J Cereb Blood Flow Metab 33:708-715.
  • Sudduth TL, Schmitt FA, Nelson PT, Wilcock DM (2013) Neuroinflammatory phenotype in early Alzheimer's disease. Neurobiol Aging 34:1051-1059.
  • Tai LM, Bilousova T, Jungbauer L, Roeske SK, Youmans KL, Yu C, Poon WW, Cornwell LB, Miller CA, Vinters HV, Van Eldik LJ, Fardo DW, Estus S, Bu G, Gylys KH, Ladu MJ (2013) Levels of soluble apolipoprotein E/amyloid-beta (Abeta) complex are reduced and oligomeric Abeta increased with APOE4 and Alzheimer disease in a transgenic mouse model and human samples. J Biol Chem 288:5914-5926.
  • Torok B, Sood A, Bag S, Tulsan R, Ghosh S, Borkin D, Kennedy AR, Melanson M, Madden R, Zhou W, Levine H, 3rd, Torok M (2013) Diaryl hydrazones as multifunctional inhibitors of amyloid self-assembly. Biochemistry 52:1137-1148.
  • Tsuang D, Leverenz JB, Lopez OL, Hamilton RL, Bennett DA, Schneider JA, Buchman AS, Larson EB, Crane PK, Kaye JA, Kramer P, Woltjer R, Trojanowski JQ, Weintraub D, Chen-Plotkin AS, Irwin DJ, Rick J, Schellenberg GD, Watson GS, Kukull W, Nelson PT, Jicha GA, Neltner JH, Galasko D, Masliah E, Quinn JF, Chung KA, Yearout D, Mata IF, Wan JY, Edwards KL, Montine TJ, Zabetian CP (2013) APOE epsilon4 increases risk for dementia in pure synucleinopathies. JAMA Neurol 70:223-228.
  • Webster SJ, Bachstetter AD, Van Eldik LJ (2013) Comprehensive behavioral characterization of an APP/PS-1 double knock-in mouse model of Alzheimer's disease. Alzheimers Res Ther 5:28.
  • Xing B, Bachstetter AD, Van Eldik LJ (2013) Deficiency in p38beta MAPK fails to inhibit cytokine production or protect neurons against inflammatory insult in in vitro and in vivo mouse models. PLoS One 8:e56852.
  • Zhang L, Dasuri K, Fernandez-Kim SO, Bruce-Keller AJ, Freeman LR, Pepping JK, Beckett TL, Murphy MP, Keller JN (2013) Prolonged diet induced obesity has minimal effects towards brain pathology in mouse model of cerebral amyloid angiopathy: Implications for studying obesity-brain interactions in mice. Biochim Biophys Acta 1832:1456-1462.
  • Abner EL, Kryscio RJ, Cooper GE, Fardo DW, Jicha GA, Mendiondo MS, Nelson PT, Smith CD, Van Eldik LJ, Wan L, Schmitt FA (2012) Mild cognitive impairment: statistical models of transition using longitudinal clinical data. Int J Alzheimers Dis 2012:291920.
  • Andersen AH, Rayens WS, Liu Y, Smith CD (2012) Partial least squares for discrimination in fMRI data. Magn Reson Imaging 30:446-452.
  • Bachstetter AD, Norris CM, Sompol P, Wilcock DM, Goulding D, Neltner JH, St Clair D, Watterson DM, Van Eldik LJ (2012) Early stage drug treatment that normalizes proinflammatory cytokine production attenuates synaptic dysfunction in a mouse model that exhibits age-dependent progression of Alzheimer's disease-related pathology. J Neurosci 32:10201-10210.
  • Barone E, Di Domenico F, Sultana R, Coccia R, Mancuso C, Perluigi M, Butterfield DA (2012) Heme oxygenase-1 posttranslational modifications in the brain of subjects with Alzheimer disease and mild cognitive impairment. Free Radic Biol Med 52:2292-2301.
  • Barone E, Mancuso C, Di Domenico F, Sultana R, Murphy MP, Head E, Butterfield DA (2012) Biliverdin reductase-A: a novel drug target for atorvastatin in a dog pre-clinical model of Alzheimer disease. J Neurochem 120:135-146.
  • Blonder LX, Pettigrew CL, Kryscio RJ (2012) Emotion recognition and marital satisfaction in stroke. Journal of clinical and experimental neuropsychology.
  • Butterfield DA, Barone E, Di Domenico F, Cenini G, Sultana R, Murphy MP, Mancuso C, Head E (2012) Atorvastatin treatment in a dog preclinical model of Alzheimer's disease leads to up-regulation of haem oxygenase-1 and is associated with reduced oxidative stress in brain. Int J Neuropsychopharmacol 15:981-987.
  • Butterfield DA, Perluigi M, Reed T, Muharib T, Hughes CP, Robinson RA, Sultana R (2012) Redox Proteomics in Selected Neurodegenerative Disorders: From Its Infancy to Future Applications. Antioxid Redox Signal.
  • Caban-Holt A, Abner E, Kryscio RJ, Crowley JJ, Schmitt FA (2012) Age-expanded normative data for the ruff 2&7 selective attention test: evaluating cognition in older males. The Clinical neuropsychologist 26:751-768.
  • Cenini G, Dowling AL, Beckett TL, Barone E, Mancuso C, Murphy MP, Levine H, 3rd, Lott IT, Schmitt FA, Butterfield DA, Head E (2012) Association between frontal cortex oxidative damage and beta-amyloid as a function of age in Down syndrome. Biochim Biophys Acta 1822:130-138.
  • Clarke DN, Al Ahmad A, Lee B, Parham C, Auckland L, Fertala A, Kahle M, Shaw CS, Roberts J, Bix GJ (2012) Perlecan Domain V induces VEGf secretion in brain endothelial cells through integrin alpha5beta1 and ERK-dependent signaling pathways. PLoS One 7:e45257.
  • Counts SE, He B, Nadeem M, Wuu J, Scheff SW, Mufson EJ (2012) Hippocampal Drebrin Loss in Mild Cognitive Impairment. Neurodegener Dis.
  • Di Domenico F, Casalena G, Jia J, Sultana R, Barone E, Cai J, Pierce WM, Cini C, Mancuso C, Perluigi M, Davis CM, Alkayed NJ, Butterfield DA (2012) Sex differences in brain proteomes of neuron-specific STAT3-null mice after cerebral ischemia/reperfusion. J Neurochem 121:680-692.
  • Di Domenico F, Sultana R, Ferree A, Smith K, Barone E, Perluigi M, Coccia R, Pierce W, Cai J, Mancuso C, Squillace R, Wiengele M, Dalle-Donne I, Wolozin B, Butterfield DA (2012) Redox Proteomics Analyses of the Influence of Co-Expression of Wild-Type or Mutated LRRK2 and Tau on C. elegans Protein Expression and Oxidative Modification: Relevance to Parkinson Disease. Antioxid Redox Signal.
  • Ding Q, Zhu H, Zhang B, Soriano A, Burns R, Markesbery WR (2012) Increased 5S rRNA Oxidation in Alzheimer's Disease. J Alzheimers Dis.
  • Duncan MJ, Smith JT, Franklin KM, Beckett TL, Murphy MP, St Clair DK, Donohue KD, Striz M, O'Hara BF (2012) Effects of aging and genotype on circadian rhythms, sleep, and clock gene expression in APPxPS1 knock-in mice, a model for Alzheimer's disease. Exp Neurol 236:249-258.
  • Ferrari R, Mok K, Moreno JH, Cosentino S, Goldman J, Pietrini P, Mayeux R, Tierney MC, Kapogiannis D, Jicha GA, Murrell JR, Ghetti B, Wassermann EM, Grafman J, Hardy J, Huey ED, Momeni P (2012) Screening for C9ORF72 repeat expansion in FTLD. Neurobiol Aging 33:1850 e1851-1811.
  • Furman JL, Sama DM, Gant JC, Beckett TL, Murphy MP, Bachstetter AD, Van Eldik LJ, Norris CM (2012) Targeting astrocytes ameliorates neurologic changes in a mouse model of Alzheimer's disease. J Neurosci 32:16129-16140.
  • Galasko DR, Peskind E, Clark CM, Quinn JF, Ringman JM, Jicha GA, Cotman C, Cottrell B, Montine TJ, Thomas RG, Aisen P (2012) Antioxidants for Alzheimer disease: a randomized clinical trial with cerebrospinal fluid biomarker measures. Arch Neurol 69:836-841.
  • Gleichmann M, Zhang Y, Wood WH, 3rd, Becker KG, Mughal MR, Pazin MJ, van Praag H, Kobilo T, Zonderman AB, Troncoso JC, Markesbery WR, Mattson MP (2012) Molecular changes in brain aging and Alzheimer's disease are mirrored in experimentally silenced cortical neuron networks. Neurobiol Aging 33:205 e201-218.
  • Gold BT, Jiang Y, Powell DK, Smith CD (2012) Multimodal Imaging Evidence for Axonal and Myelin Deterioration in Amnestic Mild Cognitive Impairment. J Alzheimers Dis.
  • Gold BT, Johnson NF, Powell DK, Smith CD (2012) White matter integrity and vulnerability to Alzheimer's disease: Preliminary findings and future directions. Biochim Biophys Acta 1822:416-422.
  • Gwon AR, Park JS, Arumugam TV, Kwon YK, Chan SL, Kim SH, Baik SH, Yang S, Yun YK, Choi Y, Kim S, Tang SC, Hyun DH, Cheng A, Dann CE, 3rd, Bernier M, Lee J, Markesbery WR, Mattson MP, Jo DG (2012) Oxidative lipid modification of nicastrin enhances amyloidogenic gamma-secretase activity in Alzheimer's disease. Aging Cell.
  • Hack N, Jicha GA, Abell A, Dean D, Vitek JL, Berger JR (2012) Substantia nigra depigmentation and exposure to encephalitis lethargica. Ann Neurol 72:912-917.
  • Head E, Silverman W, Patterson D, Lott IT (2012) Aging and Down syndrome. Curr Gerontol Geriatr Res 2012:412536.
  • Holler CJ, Webb RL, Laux AL, Beckett TL, Niedowicz DM, Ahmed RR, Liu Y, Simmons CR, Dowling AL, Spinelli A, Khurgel M, Estus S, Head E, Hersh LB, Murphy MP (2012) BACE2 expression increases in human neurodegenerative disease. Am J Pathol 180:337-350.
  • Hyman BT, Phelps CH, Beach TG, Bigio EH, Cairns NJ, Carrillo MC, Dickson DW, Duyckaerts C, Frosch MP, Masliah E, Mirra SS, Nelson PT, Schneider JA, Thal DR, Thies B, Trojanowski JQ, Vinters HV, Montine TJ (2012) National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease. Alzheimers Dement 8:1-13.
  • Ivanchak N, Fletcher K, Jicha GA (2012) Attention-deficit/hyperactivity disorder in older adults: prevalence and possible connections to mild cognitive impairment. Curr Psychiatry Rep 14:552-560.
  • Jayaraman A, Carroll JC, Morgan TE, Lin S, Zhao L, Arimoto JM, Murphy MP, Beckett TL, Finch CE, Brinton RD, Pike CJ (2012) 17beta-estradiol and progesterone regulate expression of beta-amyloid clearance factors in primary neuron cultures and female rat brain. Endocrinology 153:5467-5479.
  • Jicha GA, Abner EL, Schmitt FA, Kryscio RJ, Riley KP, Cooper GE, Stiles N, Mendiondo MS, Smith CD, Van Eldik LJ, Nelson PT (2012) Preclinical AD Workgroup staging: pathological correlates and potential challenges. Neurobiol Aging 33:622 e621-622 e616.
  • Jung KM, Astarita G, Yasar S, Vasilevko V, Cribbs DH, Head E, Cotman CW, Piomelli D (2012) An amyloid beta42-dependent deficit in anandamide mobilization is associated with cognitive dysfunction in Alzheimer's disease. Neurobiol Aging 33:1522-1532.
  • Kahle MP, Bix GJ (2012) Successfully Climbing the "STAIRs": Surmounting Failed Translation of Experimental Ischemic Stroke Treatments. Stroke Res Treat 2012:374098.
  • Kahle MP, Lee B, Pourmohamad T, Cunningham A, Su H, Kim H, Chen Y, McCulloch CE, Barbaro NM, Lawton MT, Young WL, Bix GJ (2012) Perlecan domain V is upregulated in human brain arteriovenous malformation and could mediate the vascular endothelial growth factor effect in lesional tissue. Neuroreport 23:627-630.
  • Liang C, Chan KH, Yoon PJ, Lovell MA (2012) Clinicopathological characteristics of extramedullary acute megakaryoblastic leukemia (AMKL): report of a case with initial mastoid presentation and review of literature to compare extramedullary AMKL and non-AMKL cases. Pediatr Dev Pathol 15:385-392.
  • Ling IF, Bhongsatiern J, Simpson JF, Fardo DW, Estus S (2012) Genetics of clusterin isoform expression and Alzheimer's disease risk. PLoS One 7:e33923.
  • Migongo AW, Charnigo R, Love MM, Kryscio R, Fleming ST, Pearce KA (2012) Factors relating to patient visit time with a physician. Med Decis Making 32:93-104.
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