Current Research Investigators
Yvonne Fundufe-Mittendorf, Ph.D.
Emilia Galperin, Ph.D.
Understanding the role of Shoc2 protein in spatio-temporal regulation of extracellular signal-related kinase (ERK) kinase cascade
Our goal is to define the functional importance of endosomal localization of Shoc2 for MAPK activity by utilizing
various biochemical assays and advanced methods of fluorescence microscopy.
Konstantin Korotkov, Ph.D.
Structural biology of ESX secretion system from pathogenic mycobacteria This research proposal aims to unravel the molecular mechanism of the ESX secretion system using a structural biology approach in combination with biochemical and biophysical analyses. The ultimate goal of our research is to develop novel tuberculosis therapies.
Current Pilot Investigators
Craig Horbinski, M.D., Ph.D.
Par-4 as a therapeutic target in gliomas Our overall aim is to identify for the first time how Par-4 is regulated by such alterations, and begin studying ways of exploiting Par-4 to improve glioma therapy. This new knowledge will have broader applications in developing better treatments of diffusely infiltrative gliomas.
Qiou Wei, Ph.D.
Understanding the Mechanism of Sulfiredoxin-induced Colorectal Cancer Cell Invasion and Metastasis Our overall goal is to understand the functional significance of Srx in the molecular basis of human colorectal cancer pathogenesis, in particular, to understand how Srx promotes colorectal cancer cell invasion and metastasis. Accomplishment of this goal may contribute to the future development of novel strategies targeting Srx or Srx-mediated signaling for human colorectal cancer prevention and treatment.
Rebecca Dutch, Ph.D.
A Novel Pathway Connecting Viral Replication to Assembly: The Role of Rab11 endosomes and Phosphatidylinositol-3-phosphate The 3 aims of this project are 1) Analyze the potential role of Rab11 recycling endosomes and PI3P and PI4P lipids in the replication and assembly of paramyxoviruses by study of human metapneumovirus (HMPV), parainfluenza virus 5 (PIV5) and the zoonotic Hendra and Nipah viruses. 2) Develop key reagents to be used for the program project grant, including cell lines stably expressing fluorescently-tagged versions of the HMPV, PIV5 or Hendra M proteins. 3) Present a minisymposium at UK with Drs. Schmitt, Altan-Bonnet and Cameron as guest speakers.
M. Paul Murphy, Ph.D.
Diabetes, Metabolism and Dementia Our goal is to generate additional data on the systemic, metabolic pathology in this mouse line (db/AD) in order to produce a competitve proposal evaluating and targeting the mechanisms connecting diabetes and dementia.