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Five high-tech small businesses affiliated with the University of Kentucky receive state matching grants

Editor's note: Five of the seven companies receiving $1.8 million in Kentucky matching funds have ties to the University of Kentucky. The high-tech companies are: Orthopeutics/Intralink (relocated to Coldstream Research Campus from Austin, Texas, Tom Hedman has joined the faculty with a joint appointment in biomedical engineering and neurosurgery), nGimat (working with College of Engineering and the UK Center for Applied Energy Research), 3H Company (located in UK's largest on campus incubator known as ASTeCC, will be moving soon to Coldstream Research Campus), Vindico NanoBioTechnology (located in UK's ASTeCC campus incubator), and Advanced Dynamics (located at Coldstream Resaerch Campus). Company descriptions are at the end of the press release.


LEXINGTON, Ky. (Sept. 22, 2010) —Gov. Steve Beshear announced awards totaling more than $1.8 million to seven Kentucky high-tech companies as part of a Kentucky initiative to attract and support technology-based small businesses. Through the state's competitive SBIR-STTR Matching Funds program, Kentucky matches federal SBIR-STTR awards received by Kentucky companies or those willing to relocate to Kentucky. This seventh round of state awards supplements more than $2.4 million in federal funding made to the firms.


The state matching funds were awarded after the high-tech firms received grants in Phase 1 or Phase 2 of the federal Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs. Kentucky is the first and only state to match both phases of the federal program: up to $150,000 to match Phase 1 federal awards and up to $500,000 per year to match Phase 2 federal awards. To date, the state's SBIR-STTR matching program has made a total of 91 awards to 52 Kentucky high-tech companies for a combined $20.5 million in state funds, leveraging more than $37.4 million in federal funds. The program has also helped bring 10 new high-tech businesses to the Commonwealth to benefit from the matching funds.


"Kentucky's unique program is widely recognized as the top SBIR-STTR matching program in the nation," said Gov. Beshear. "Not only do these awards help support our high-tech small businesses, they bring in tens of millions of dollars in federal funding that indirectly benefit other Kentucky companies and their employees who provide products and services in support of our research industry."


The seven Kentucky companies receiving matching funds specialize in areas as diverse as human health and development, energy, nanotechnology, bioscience, materials science and advanced manufacturing.


Company descriptions:

nGimat Co., which relocated from Georgia to Lexington, will initially develop advanced energy storage nanomaterials for use in next-generation lithium-ion automotive batteries, as well as in energy storage components for the emerging electrical smart-grid. nGimat's facility will also produce nanopowder using the company's proprietary process.


Advanced Genomic Technology LLC, of Louisville, is developing a genetic test to identify specific disease biomarkers in patients who have Alzheimer's disease.


Talon Technologies, of Covington, is developing a high-performance flexible conduit for use with the Army's rapidly installed fuel transfer system during active combat deployments.


Orthopeutics Inc., which relocated from Texas to Lexington, is developing a nonsurgical treatment for degenerative disc disease and associated lower-back pain. The treatment involves injecting a tissue revitalization material into the spinal disc to mechanically reinforce and stabilize the joint and decompress the surrounding neural tissues without the need for invasive spinal surgery.


3H Company LLC, of Lexington, is developing technology that captures and stores carbon dioxide underground to help reduce greenhouse gas emissions from coal-fired power plants. The company's novel absorbent also helps reduce energy loss during the coal capture process.


Vindico NanoBio Technology Inc., of Lexington, is developing a synthetic oxygen therapeutic, a blood substitute, that can be administered to patients and help reduce blood shortages.


Advanced Dynamics Inc., of Lexington, is developing software that enables more accurate designs of aircraft wings and rotor blades, while providing rapid and reliable aeromechanics assessment.


The Cabinet for Economic Development, through its Department of Commercialization and Innovation (DCI), manages the Kentucky SBIR-STTR Matching Funds program, which is administered under contract to DCI by the Kentucky Science and Technology Corporation (KSTC).


"Kentucky's SBIR-STTR matching program has generated a lot of interest nationwide," said DCI Commissioner Deborah Clayton. "Not only have the awards brought 10 high-tech firms – and their jobs – to Kentucky from other states, but they have greatly increased the number of Kentucky companies that are applying for and winning federal SBIR and STTR awards."


Applications for each round of the program are accepted by KSTC on a regular basis. A link to the online guidelines and application form for the Kentucky program are posted at

United States Equestrian Federation Equine Drug Testing and Research Lab moving to UK's Coldstream Research Campus

LEXINGTON, Ky. (Sept. 17, 2010) —Already the site of the 2010 Alltech FEI World Equestrian Games, First Lady Jane Beshear announced Lexington will be the location of the United States Equestrian Federation's (USEF) Equine Drug Testing and Research Laboratory. USEF will relocate the specialized equine drug testing facility from Ithaca, NY later this year, creating a dozen specialized new jobs and a capital investment of nearly $1.5 million to the Commonwealth.


"USEF's equine drug testing and research lab will be an excellent addition to the Commonwealth, already known as the Horse Capital of the World," said Mrs. Beshear. "The creation of a dozen, high-paying jobs, dedicated to providing and maintaining a safe and level playing field for equine athletes, will have a positive effect on the Lexington community."


The University of Kentucky's Coldstream Research Campus will be home to the new facility, which is expected to occupy a 7,500-square-foot space. In addition to testing more than 15,000 samples each year collected from USEF licensed competitions across the country and samples from the American Quarter Horse Association (AQHA), the USEF's lab will be fully capable of serving any additional needs for equestrian sport.


"Our facility is one of the world leaders in cutting-edge drug testing and research," said John Long, CEO of the USEF. "During the last few years, the size and scope of our program has nearly doubled. Growth of this size presents challenges and we look forward to meeting those challenges by relocating our facility closer to our headquarters, in the heart of Lexington."


Before making its transition to Lexington, the lab in Ithaca will be responsible for processing the samples collected during the 2010 Alltech FEI World Equestrian Games. The lab is one of only five in the world used by the Fédération Equestre Internationale (FEI) to receive samples collected at FEI competitions.


In addition to the relocation of the lab, Mrs. Beshear also announced a partnership between USEF, the U.S. Eventing Association and the University of Kentucky's College of Engineering that will have a significant impact on safety in the equestrian sport of eventing. An Olympic sport and part of the World Equestrian Games, eventing includes dressage, cross country and stadium jumping.

The UK research team is working to develop new designs and new materials for cross country jumps that will greatly decrease the chance of severe injuries to the rider and horse. While these injuries are infrequent, the severity of the injury has led a worldwide effort to reduce their occurrence and improve eventing safety.


"We are very proud to be in partnership with USEF," said UK President Lee T. Todd Jr. "Having this lab at Coldstream provides great synergy between USEF and our researchers, and will attract even more equine-related businesses to our research campus. Currently, there are seven equine-related companies and the UK College of Agriculture Veterinary Diagnostic Laboratory (formerly the UK Livestock Disease Diagnostic Lab) at Coldstream."


Established in 1917, USEF serves as the National Governing Body for Equestrian Sport. The federation trains, selects and funds the United States Equestrian Team which consistently wins medals at the highest level of international competition, including the Olympic Games. The USEF also licenses 2800 equestrian competitions of all levels across the United States each year in 28 different breeds, national disciplines and international disciplines.


"We have some of the world's top equine researchers at the University of Kentucky Gluck Center and the world's best horses. USEF will be a welcome addition," said Lexington Mayor Jim Newberry. "This is another clear example of the capacity of the horse industry and the strength of UK research to attract good jobs to our community."


"Commerce Lexington is excited that USEF has chosen to relocate its equine testing lab to Lexington," said Bob Quick, president and CEO of Commerce Lexington Inc. "Having a world-class lab in Lexington will only strengthen our standing as the Horse Capital of the World. Congratulations to USEF on their expansion in the Bluegrass."


USEF was preliminarily approved by the Kentucky Economic Development Finance Authority for up to $300,000 in tax incentives through the Kentucky Business Investment program. The performance-based incentive can be earned over a 10-year period through corporate income tax credits and wage assessments. The average annual approved amount to be earned by USEF is $30,000.


A detailed community profile for Lexington (Fayette County) can be viewed at Lexington Community profile. Information on Kentucky's economic development efforts and programs is available at

George Ward named executive director of Coldstream Research Campus

LEXINGTON, KY (September 14, 2010) — The University of Kentucky Board of Trustees approved the appointment of George Ward as the new executive director of the university's Coldstream Research Campus.


George WardWard, who has served as a Kentucky commerce cabinet secretary, has 30 years of executive experience in hotel and real estate development, finance and business operations, and government relations.


"We believe that George has all of the qualifications and experience that will be critical to take Coldstream Research Campus to the next level," said University of Kentucky President Lee T. Todd Jr.


Last year, consultants were hired to update the Coldstream master plan according to UK Vice President for Commercialization & Economic Development Len Heller. Heller and Ward will announce the new long term vision for Coldstream and details on the first phase of development later this year. 


"Serving as the executive director of the Coldstream Research Campus fulfils a personal goal to utilize my business and marketing skills and past experience to contribute to Kentucky's future," said George Ward. "I consider it an honor to be part of the team that is assisting Dr. Todd in fulfilling UK's economic development mission as the land-grant institution and economic engine for the Commonwealth."


Ward, who was president of H&W Management Co. Inc., a regional hotel development and real estate company, for 18 years, was appointed Kentucky State Parks commissioner in 2004 and later served as Kentucky Commerce Cabinet secretary until December 2007. Most recently, he has worked with Transposagen Biopharmaceuticals Inc., an early stage biotech company that relocated to Lexington from Philadelphia, Pa. and is located in UK's ASTeCC campus incubator. Ward also serves on the board of directors of Commerce Lexington and is a member of the Bluegrass Regional Public Policy Council.


Coldstream Research Campus is currently home to some 65 companies and more than 1,000 employees. The companies at Coldstream include IBM, HP, Embassy Suites Hotel, the UK Veterinary Diagnostic Laboratory (formerly the UK Livestock Disease Diagnostic Lab), Kentucky's largest sterile pharmaceutical manufacturing facility Coldstream Laboratories Inc., and other biotech, pharmaceutical, equine-related and service businesses.


Ward has lived in Lexington since 1984. He and his wife, Lorie, have six children, including three children currently enrolled at the University of Kentucky.

Larry Kranking named CEO of Coldstream Laboratories Inc.

LEXINGTON KY (August 23, 2010) — Larry Kranking has been named the new President and CEO of Coldstream Laboratories Inc. (CLI), the largest sterile pharmaceutical manufacturing facility in Kentucky.


Kranking, who comes to CLI from Aveta Lifesciences-usa in Valparaiso, Ind., has 38 years of experience as a pharmaceutical executive leading start-up companies and implementing innovative regulatory strategies. Kranking will head a staff of 70 who provide full service GMP sterile manufacturing services for international biotech and pharmaceutical clients who require small batches of product for use in pre-clinical trials to commercial distribution.


"Larry is an internationally recognized industry leader who has helped develop the guidelines that define today's biopharma manufacturing world," said Len Heller, chairman of the board of CLI. "Larry also brings expertise in the area of ANDA drug development which will be important to CLI as we move into our fourth year of operation," said Heller, who also serves as the University of Kentucky Vice President for Commercialization & Economic Development.


"CLI is in an excellent position to expand our customer base and services as we leverage the University of Kentucky's position as a premier research institution and global leader in cancer research and drug development," said Larry Kranking, whose business operations experience includes the startup of cGMP manufacturing facilities for Boehringer Ingelheim and Eisai Inc. "We want to position Coldstream Laboratories as the bridge between drug discovery and commercial business."


Kranking replaces Joe Wyse who transitioned CLI from the University of Kentucky Center for Pharmaceutical Science & Technology to a private business in 2007. "Joe has done a tremendous job the past three years navigating all of the issues and regulations inherent in a start-up business and a cGMP pharma operation while starting to build an international client base," said Heller.


Coldstream Laboratories Inc., located at the Coldstream Research Campus, is wholly owned by the University of Kentucky through the University of Kentucky Research Foundation.

Coldstream's barn owls fledge, nesting box installed

LEXINGTON, KY (July 28, 2010) — Coldstream's temporary tenants, a pair of federally protected barn owls and their chicks, have fledged and a permanent nesting box has been installed. Barn owls have what scientists call a high "nest fidelity," meaning they often return to the same nest each year.


Barnowl"The owls will come back and find their nest has been closed up and hopefully they will find our box to be suitable since it's so close (to the original nest)," said Kate Heyden, an avian biologist with the Kentucky Department of Fish and Wildlife Resources. The new nesting box was installed near the owl's original nest near the top of the Lexhold building and provides a plywood space 2.5 ft. wide and 1ft. high.


"I watched one of the chicks take its first flight," Heydon said. "It flew to the rooftop ... of the building, then took many small flights from there to build up its strength."


She said the owl family might still be seen around the building for the next month or so and the adults will stay in the area through the winter. The owls were first discovered in June by a construction worker who was completing final detailing on the building. Wildlife officials were called in and construction halted until the young birds flew away.


Biologists think the numbers of barn owls are decreasing because the owls like to nests in old trees with hollow spaces or in hay barns or other old buildings that are becoming increasingly scarce.

New body temperature alert patch allows athletes and others to "beat the heat"

Editor's note: ionX International Inc. is headquartered at UK's Coldstream Research Campus. Read more on ionX and the iDot patch in Business Lexington.


LEXINGTON, KY (June 25, 2010) — After being stuck in gyms and indoor workout facilities during the frigid winter months, cyclists and runners are filling parks and roadways, relishing the warmer weather. Baseball diamonds and golf courses are teeming with players, and spring training is in full swing on high school and college athletic fields across the country. And while the shift to the outdoors is always welcome after a long winter, the sun can quickly warm to the point of danger for those who play — and work — in the heat of day.


To serve as a first line of defense against overheating and possible hyperthermia, ionX International has recently launched its Body Temperature Alert Patch, an early warning device, designed to help prevent heat stroke and potentially save lives. As the wearer's core body temperature increases, the disposable, single-use ionX Alert Patch changes from black to bright yellow, warning the wearer if and when there is a danger of overheating. Once the individual has cooled to a non-risk temperature, the patch will return to the original color. (The patch will change color again when the body temperature increases to an elevated level.) By mid- to late-June, the ionX Alert Patch will be available at more than 550 retail outlets nationwide, including The Sports Authority and select Hibbett Sports.


Easy-to-use ionX Alert Patch signals a "first warning"
The patented nano-polymer technology of the Alert Patch responds to core body temperature changes, allowing it to indicate rise and fall of temperature. When the wearer's core temperature reaches elevated levels, the Alert Patch begins to change from black to yellow. At a risk point, the patch turns a noticeable yellow that is easily visible, even from a distance as far away as the sidelines. The patch does not react to external temperatures or humidity; and since the inks do not wear out, the patch will continue to change color and measure body temperature as long as it is worn.


With the same characteristics and application of a bandage, the Alert Patch is round, elastic and waterproof, staying securely in place during physical activity. Due to the nature of the adhesive, the patch is designed for a single use. To accurately measure core temperature, the Alert Patch is placed on an area with blood vessels or capillaries close to the surface of the skin on the neck artery; the bicep just before the inner elbow; the inner forearm just before inner elbow; or the wrist just before the hand.


Dog days of summer can have tragic consequences
Summer can bring heat waves with unusually high temperatures that last for days or even weeks. Nearly 700 people in the U.S. die each year from exposure to heat (with thousands more treated in emergency situations), and heat stroke is the third-leading cause of death for high school athletes. Naturally, hotter weather can be even more devastating: The United States experienced an intense heat wave in the summer of 1980, resulting in nearly 1,700 deaths from heat-related illness. And in the summer of 2003, tens of thousands of Europeans died during a similar heat wave. But heat-related illnesses and fatalities are completely preventable if a person knows he or she is close to overheating and takes steps to reduce their heat exposure.


Human beings suffer heat-related illness when the body's temperature control system is overloaded. The body normally cools itself by sweating. In certain conditions, such as high humidity, sweating doesn't cool the body effectively and body temperature rises rapidly, which can damage the brain or other vital organs. Other factors that can limit the body's ability to regulate temperature include old age, obesity, fever, dehydration, heart disease, poor circulation, sunburn and drug or alcohol use.


About ionX International, Inc.
Lexington, Kentucky-based ionX International, Inc. is wholly owned by Ionx Capital Holdings, Inc. (ICH), a diversified, private-equity company engaged in product development. The Body Temperature Alert Patch is one of many new technologies created for improved health and wellness by ICH.

Allylix featured in The Economist

LEXINGTON, KY (June 24, 2010) — Allylix is featured in this week's edition of The Economist in a special section titled "A special report on the human genome: Inhuman genomes." Allylix, a biotechnology firm, licensed its original technology from UK's College of Agriculture and today uses it for the low cost production of high-value terpene products through yeast fermentation. UK is part of the original investors in Allylix through Kentucky Technology Inc. and the Bluegrass Angel Fund. Individual Bluegrass Angels are also original 2004 investors and joined national investors in 2007 for a $3.35 million B round of funding. Allylix has business offices in San Diego, Ca. and research and development laboratories at UK's Coldstream Research Campus. See for additional information.

Protected Barn Owls nest at Coldstream

barnowlLEXINGTON, KY (June 4, 2010) — UK's Coldstream Research Campus has new, though temporary, tenants. Protected under the federal Migratory Bird Treaty Act, a pair of nesting barn owls is raising four barn owl chicks in a nest at the top of the Lexhold building off Aristides Boulevard.


The owls were first discovered by a construction worker who was completing the building's "eyebrow," an architectural feature that runs across the top of the building. Wanting to be good environmental stewards, Bill Bishop, who is overseeing the completion of the building, and construction manager Bill Borregard contacted the state fish and wildlife experts to identify the birds.


The preservation of barn owls is a major concern in much of the U.S. including Kentucky. The birds traditionally nest in hollowed out tree cavities. As these become increasingly scarce, however, the owls have moved to barns and other structures adjoining vast pastoral spaces.


According to Kate Heyden, an avian biologist with the Kentucky Department of Fish and Wildlife Resources, there are currently only 10 known nests in Kentucky. Construction on the Lexhold building will be delayed until the end of June when it is expected that all of the barn owl chicks will leave the nest. An agreement has also been made to install an owl box on top of the eyebrow as barn owls often return to the same spot to nest again.

FEMA leases space at Coldstream Research Campus

LEXINGTON, KY (June 2, 2010) — The Federal Emergency Management Administration (FEMA) has leased space at the University of Kentucky's Coldstream Research Campus following Kentucky's designation as a major disaster area May 11. Approximately 61,000 square feet in the Lexhold Technology Building off Aristides Boulevard will serve as a central coordinating location for the 300 FEMA professionals who have been mobilized for federal recovery operations in affected Kentucky counties.


According to Len Heller, UK's vice president for Commercialization and Economic Development, FEMA selected Coldstream because of its location at the intersection of I-75 and I-64.


The FEMA Web site is reporting that people in 61 Kentucky counties are eligible for individual assistance (assistance to individuals and households) following the May 1 severe storms, flooding, mudslides, and tornadoes.


FEMA and the Kentucky Division of Emergency Management are operating disaster recovery centers around Kentucky. Please note that the facility at Coldstream is not a disaster recovery center. Additional information is available at and or by calling toll-free 800-621-FEMA (3362) (for TTY call 800-462-7585).

USEF Drug Testing and Research Lab will relocate to Coldstream Research Campus

LEXINGTON, KY (April 5, 2010) — The drug testing and research lab for the United States Equestrian Federation will relocate from Ithaca, N.Y. to UK's Coldstream Research Campus by the end of the year. According to UK Vice President for Commercialization & Economic Development Len Heller, "USEF will move their research and testing operations into a re-fitted, 7,500 sq. ft. lab space in the Kentucky Technology Center complex at Coldstream called the mini campus."


The USEF is headquartered at the Kentucky Horse Park and drug tests and licenses equestrian competitions of all levels across the country, in addition to training, selecting and funding the U.S. Equestrian Team. "The decision to bring the lab to Lexington has to do with many things including being headquartered here, but it also has to do with being part of the legacy of the World Equestrian Games this fall," says USEF CEO John Long.


The 2010 Alltech FEI World Equestrian Games will be held at the Kentucky Horse Park September 25 to October 10. The new USEF testing lab at Coldstream Research Campus is anticipated to bring 12 jobs paying an average $26 an hour including benefits.

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