Melanie Hardin-Pierce DNP, RN, APRN, ACNP-BC
Associate Professor; Adult-Gerontology/Acute Care Nurse Practitioner DNP Track Coordinator

Melanie Hardin-Pierce has an extensive background in adult critical care. Her research interests include improving outcomes in the mechanically ventilated adult critically ill patient population, prevention of ventilator-associated pneumonia, and positional therapy as an adjunct treatment for acute respiratory distress syndrome. She has written numerous textbook chapters in the area of high acuity nursing and is a co-editor of an award-winning nationally recognized critical care textbook, High Acuity Nursing (5th edition). She is active in research and evidence-based practice issues. Dr. Hardin-Pierce is an associate professor in the college where she teaches in the graduate program. She is an acute care nurse practitioner at the VA Medical Center in Lexington, and also is involved in research in the adult critical care services division at UK's Albert B. Chandler Hospital.

Contact Information

Phone: (859) 323-5658

Fax: (859) 323-1057




DNP, University of Kentucky, 2006
Post-Masters Clinical Scholars Program, University of Kentucky, 1998
MSN, University of Kentucky, 1992
BSN, University of Kentucky, 1986
ADN, Lexington Technical Institute, 1981


Prevention of ventilator-associated pneumonia; improving outcomes in critically ill adults; cardiovascular function and weaning outcomes in patients requiring mechanical ventilation


Dr. Melanie Hardin-Pierce's CV


Hammash, M. H. Moser, D. K. Frazier, S. K. Lennie, T. A. Hardin-Pierce, M. G. Heart rate variability as a predictor of cardiac dysrhythmias during weaning from mechanical ventilation. (2015), American Journal of Critical Care 24 (2), 118-127.

Reeves, G. Alhurani, A. Frazier, S. K. Watkins, J. Lennie, T. A. Hardin-Pierce, M. G. The association of comorbid diabetes mellitus and symptoms of depression with all-cause mortality and cardiac rehospitalization in patients with heart failure. (2015), BMJ Open Diabetes Research & care 3

Hammash, M. Moser, D. K. Frazier, S. K. Lennie, T. A. Hardin-Pierce, M. G. Heart rate variability predicts occurrence of cardiac dysrhythmias duroing ventilator weaning . (2015), American Journal of Critical Care 24 (2), 118-127.

Hardin-Pierce, M. G. Alterations in Gastrointestinal Function High acuity nursing. (2014), Prentice Hall Health (6),

Pfeifle, A. L. Hardin-Pierce, M. G. McDowell, S. M. Graduate Interprofessional Leadership Development to Facilitate Collaboration, Safety, and Quality in an Integrated Healthcare System. (2014), All Together Better Health VII


Boling, B., Hardin-Pierce, M. G., Jensen, L. A., Hassan, Z. U. 2015, October. Evaluation of a High- Fidelity Simulation Training Program for New Cardiothoracic ICU Nurses. The Society of Thoracic Surgeons (STS) and the Foundation for the Advancement of Cardiothoracic Surgical Care (FACTS-Care), Washington, DC .

Garrett, N., Hardin-Pierce, M. G., Lowry, G., Okoli, C. T., Bradley, J. 2015, November. 2013 Jin Shin Jyutsu® Patient Response. 25th Annual Nursing Research Papers Day, Lexington, KY .

Ratermann, L. M., Frazier, S. K., Jones, A. R., Hardin-Pierce, M. G. 2015, April. Association of Drug and Alcohol Use with Trauma Severity Outcomes. Undergraduate Research Showcase, University of Kentucky, Lexington, KY .

Hardin-Pierce, M. G., Tovar, E. G., Yates, A., Bennett, T. L. 2015, April. A Graduate Elective to provide Inter-professional Education on Collaboration and Application of the 8-Step LEAN approach to Quality Improvement. NONPF 2015 Annual Meeting, National Organization of Nurse Practitioner Faculties (NONPF), Baltimore, MD United States.

Routt, J. C., Frazier, S. K., Hardin-Pierce, M. G. 2015, April. Regional Differences in Trauma Features, Clinical Management and Outcomes. Undergraduate Research Showcase, University of Kentucky, Lexington, KY .