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D. studentTPIdtADPSpcACSEndUgrCHK7@BHector @ @ @ Hernandez, Visiting ResearcherTPIdtADPSpcACSEndOA@ Heading6 (H6)P@ @@ @Y@P@@@pE AN@` P+ A%IKb@CH H Research in this laboratory uses advanced methods of signal processing and computational modeling to detect and diagnose abnormal physiological behaviors that result from disease or injury. Our current interests focus on: H B@ @ @ F(i)H H heart and brain injury resulting from carbon monoxide poisoning, and; (ii) abnormal electrical activation of the brain associated with sleep-disordered breathing. Our research involves intensive mathematical modeling using the H B@ @ @ GACSLH H simulation suite and H B@ @ @ ComsolH HD H B@ @ @ Multiphysics,H H. and state-of-the-art signal processing using H B@ @ @ MATLABH H and IDL.H cSEndm $ZD9 'A 'A;@iAAIRPA 'BH @ SuperTableI &BzqE R% A 8@s &,:A )A )Ab@Q $ @ @ SuperTable )A 'E *A *A $@i!A@BQJ0PA *A $P@DTableI ) (&@  F )9 ~A~A &@Q ' @@FTable{A &X@BffM?@A 'A #F '@pH@I@AvA +q@ */ +A +A '@iAA@Bp0@A +A 'P@BRowZP +7 *@i A@PP@PAFA *P@CCellI~AoAx ~% )@Q + @@FStorygAbYAANAZNFhf43A~@D@ HResearch InterestsTPIdtACSEndCB bSNb@D@ HC A 3D@HE @cSEndTCAIRNT@pAb@CHHCarbon Monoxide (CO) PoisoningHdPAlnATCSEndm 3Xqq 5A 5A;@iaAIRPA 5B~H @ SuperTableI 4BzqE R A 8@s 4)tr 6A 6Ab@Q 3 @ @ SuperTable 6AX 5E 7A 7A 3@i!A@BQJ0PA 7A 3P@DTableI 6 (&@  < 69 9A 9A 4@Q 5 @@FTable 9A 4X@BffM?@A 5A # < 5@pH@I@y 8q@ 7/ 8A 8A 5@iAA@Bp0@A 8A 5P@BRowZP 87 7@i A@PP@PA ,@@StoryG<W@@N G-N?s<RF @@StoryN?WHHN N-UGs<RM @@StoryUGWOON U-\Ns<RT @@Story\NWVVN \-eUs<R[,@@StoryeUT]]AN e*r\s<Rd @@Storyr\WffNsr. 4:ttb@Rq @ @ SuperTabletet; w|rRs @@TablewrP@BffM?@Ds w+| tRv @@Story|tWxxN |*rwstR{ @@FStoryXBwW}}NZ1Z0,up I T@ Ab@ATPAlnAOCSEnd rHBZAb@  tZA PP  = UAUxpA@P? xpA@PZ3 ?B ? q 6A >C > =K = 6ZB NT@QAb@CHH=Learn more about our research on CO poisoning by clicking on @HCarbon Monoxide ResearchHH on our home page.HcSEnd%BA RNT@ Ab@CHcSEnd2p Kb@BD9TPAlnATCSEndm9[ $q;;;@i!ABR@0@D;`P @ SuperTableM:y FyE R A E@p2B HAb@BDqTPAlnAOCSEndmq[9 3Gss;@iaAIRPEskH @ SuperTableMrzqE Sp A 8@  ZNu@BAASSEndkZA*y;@@EFrame6Q E@ QJ00DP@DFrameIAiAjAEAx @RAkA  A@ @Ql@SNv@ASSEndHqy?@@HTML_TableCell_DefaultXH@PXXAAZP@CCellIA+[ SN@ASSEndIAy?@@HTML_TableCell_FixedXH@PXXAAP@CCellIA+[ SN@ASSEndLBq?@@HTML_TableCell_PercentXH@PXXAAP@CCellIA+[ SN@ASSEnd\[Ay<@ @ HTML_IsMapQ H@IQXAAP@DFrameIAGyE @YnA  Al@SN@ASSEnd^Ay<@ @ HTML_FormQ H@IQXAAP@DFrameIAGyE @YnA  XQF@SN@ASSEndhAy<@@HTML_Form_DropDownListQ H@IQXAAP@DFrameIAGyE @YnA  Al@SN@ASSEndiAy<@@HTML_Form_MultiLineEditQ H@IQXAAP@DFrameIAGyE @YnA  Al@SN@ASSEndjAy<@@HTML_Form_SingleLineEditQ H@IQXAAP@DFrameIAGyE @YnA  Al@SN@ASSEnddAy<@@HTML_Form_CheckBoxQ H@IQXAAP@DFrameIAGyE @YnA  Al@SN@ASSEndaAy<@@HTML_Form_RadioQ H@IQXAAP@DFrameIAGyE @YnA  Al@SN@ASSEndaAy<@@HTML_Form_ImageQ H@IQXAAP@DFrameIAGyE @YnA  Al@SN@ASSEndbAy<@@HTML_Form_SubmitQ H@IQXAAP@DFrameIAGyE @YnA  Al@SN@ASSEndaAy<@@HTML_Form_ResetQ H@IQXAAP@DFrameIAGyE @YnA  Al@SN@ASSEndaAy<@@HTML_Form_TypedQ H@IQXAAP@DFrameIAGyE @YnA  Al@SN@ASSEnd[Ay<@@ Default FrameQ H@IQXAAP@DFrame:A;A@fA`y<@@Default Graphic/OLEQ L@ QJ00A*@@H@DFrameI A7A8 @Y5 A9@SN @ASSEnd`<@@Default Drop CapQ" H@IQXD9[P @FDropCapIgAxH@@Default Drop Cap Style$@@ Default TextI:AMAEAA&@Ae b Ad@@PANg@ASSEnd>A=i A@PRPEE=H@CCellL?GAMAEAx  @S?D@H @B@ @ @ Alonso,@H J. F., M. A. @B@ @ @ Maanas,@H D. @B@ @ @ Hoyer,@H Z. L. @B@ @ @ Topor,@H E. N. Bruce. Evaluation of Respiratory Muscles Activity by means of Cross Mutual Information Function at Different Levels of @B@ @ @ Ventilatory@H Effort. HHIEEE HB@ @ @ TransHHD HB@ @ @ BiomedHHD HB@ @ @ Engrg@H (in press)@cSEndFAEi A@PRPELEH@CCellLGGAMAEAx  HKSGCHH HB@ @ @ MathewHHG B, HB@ @ @ HudgelHHb D, Bruce M, and Bruce E. Entropy of electroencephalogram (EEG) signals varies with sleep state. HB@ @ @ Experim.HH Biology HB@ @ @ Conf.,HH$ San Francisco, CA, April 1-4, 2006.@cSEndMALi A@PRPESLH@CCellLNGAMAEAx  OGSND@HX Bruce, E. N. Mechanisms and consequences of sleep apnea and periodic breathing. HHhEuropean Union "Marie Curie Training Event ", Biomedical Modeling and Cardiovascular-respiratory Control@H, University of @B@ @ @ Graz,@H Austria; Aug. 1-4, 2007.@cSEndTASi A@PRPEZSH@CCellLUGAMAEAx  VCZUCH H%Our recent publications in this area:SSEnd[AZi A@PRPEcZH@CCellL\GAMAEAx  ]h \CH H" Sleep-disordered breathing H B@ @ @ (SDB)H H is a clinical abnormality in which a patient experiences repeated episodes of insufficient breathing during sleep. These events can lead to inadequate levels of blood oxygen H B@ @ @ (hypoxia),H H4 which may cause tissue injury in the brain, and to H B@ @ @ arousals,H H= which disrupt sleep and cause sleep fragmentation. Serious H B@ @ @ FSDBH H2 occurs in about 4% of the population, being more H B@ @ @ prevelantH H in males, and mild H B@ @ @ FSDBH He may be present but largely undiagnosed in 15% of the population. Obstructive sleep apnea syndrome H B@ @ @ (OSAS)H H is a form of H B@ @ @ FSDBH H in which breathing is reduced or blocked by obstruction of the upper airway due to encroachment of soft tissues into the airway lumen.H dPAlnA@DPIdtA 0DPSpcA 8CSEndhF B]@S\CH H Aging is associated with major changes in the quality of sleep. The resulting problems are widespread, as more than 80% of adults 65 H B@ @ @ EyrH Hn and older report some degree of sleep disruption. The incidence of sleep fragmentation and the frequency of H B@ @ @ arousalsH H@ and awakenings increase significantly with age. ÂH B@ @ @ HypoxiaH HI and sleep fragmentation each contribute to the neurological and related H B@ @ @ morbiditiesH HD H B@ @ @ asociatedH H with H B@ @ @ FSDBH H. and aging - memory and executive impairment, H B@ @ @ psychosocialH HC difficulties, daytime sleepiness, and excessive rate of accidents.H dPAlnA@DPIdtA 0DPSpcA 8CSEnd  ]AhIK\CH H^ Our current work in this area focusses on diagnosing the causes and consequences of H B@ @ @ FSDBH HG through novel signal processing of electroencephalogram (EEG) signals.H dPAlnA@DPIdtA 0DPSpcA 8CSEnd]q PHA\ASSEndd>ci A@PRPEkcH@CCellLeGAMAEAxfEZNF435\CeD@HSleep and EEG ResearchTPAlnATCSEndv;ui A@PP@PEzuH@CCellLwoAx  xPANFhf(CwASSEnd{8zi A@PP@PE~zH@CCellL|oAx}[SNFhfz*C|CHH3Learn more about our research on EEG analyses in slHHeep by clicking on @HEEG/Sleep ResearchHH on our home page. 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