|
Research Interests |
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| • Medical Optical
Spectroscopy/Imaging of
Tissue
Hemodynamics • Image Processing, 3D Image Reconstruction and Visualization • Bone Biomechanics and Physiological Modeling |
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| Education | ||
| 9/2004 - 7/2008 | Tsinghua University, P. R. China | Ph.D., Biomedical Engineering |
| 9/2001 - 7/2004 | Jilin University, P. R. China | M.S., Biomedical Engineering |
| 9/1995 - 7/1999 | Jilin University, P. R. China | B.S., Applied Mathematics |
| Work Experience | ||
| 7/2011-now | Postdoctoral Fellow (AHA postdoctoral fellowship) | |
| Center for Biomedical Engineering | University of Kentucky, USA | |
| 7/2008 – 7/2011 | Postdoctoral Scholar | |
| Center for Biomedical Engineering | University of Kentucky, USA | |
| 6/2000 – 8/2004 | Assistant Lecturer | |
| School of Mathematics | Jilin University, P. R. China | |
| 7/1999 – 6/2000 | Assistant Lecturer | |
| Department of Mathematics | Changchun University of Science and Technology, P. R. China | |
|
Teaching
Courses: Complex Function, Partial Differential Equation, Probability and Statistics |
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| Activities | |
| 9/2005 – 1/2008 | Tsinghua University |
| Teaching assistant in the course ‘The simulation and modeling of physiological system’ at Medical School | |
| 3/2006 – 7/2007 | Tsinghua University |
| Teaching assistant in the course ‘The advanced technology for medical engineering’ at Medical School | |
| 5/2005 – 5/2006 | Tsinghua University |
| Associate president in the Graduate Association of Medical School | |
| Manuscript Referee for Journals |
| Optics Letters, Optics Express, Biomedical Optics Express, Applied Optics, Physics in Medicine and Biology, Journal of Cerebral Blood Flow and Metabolism, Physiological Measurement |
| Scholarships and Awards | |
| 2011 | Travel fellowship for the ECI conference Advances in Optics for Biotechnology, Medicine and Surgery XII |
| 2007 | The third scholarship of Tsinghua University |
| 2006 | The excellent lecturer of the 129th Tsinghua Forum for Doctoral Candidates |
| 2006 | The excellent graduate leader of medical school, Tsinghua University |
| 2005 | The Cathay-east scholarship of Tsinghua University |
| 2005 | The second prize of 2005 National Post-graduate Mathematical Contest in Modeling |
| 2003 | The first prize of 2003 China Undergraduate Mathematical Contest in Modeling (national-level, as the instructor) |
| Professional Membership | ||
| 2011- | Member | American Association for the Advancement of Science (AAAS) |
| 2010- | Member | Optical Society of America (OSA) |
| 2009- | Member | The International Society for Optical Engineering (SPIE) |
| 2009- | Member | Biomedical Engineering Society (BMES) |
| Publications | |
| Selected peer-reviewed publications (in chronological order) | |
| - | L. Chen, Y. Shang, E. Sipos, K. E. Saatman, G. Yu, M Toborek, “A novel mouse model for repeated forebrain ischemia-reperfusion using a customized vascular occlude,” Journal of experimental stroke and translational medicine, Submitted (2012). |
| - | L. Dong, M. Kudrimoti, R. Cheng, Y. Shang, E. L. Johnson, S. D. Stevens, B. J. Shelton, and G. Yu, “Noninvasive diffuse optical monitoring of head and neck tumor blood flow and oxygenation during radiation delivery,” Biomedical Optics Express, Vol. 3 Issue 2, pp.259-272 (2012). |
| - | Y. Lin, L. He, Y. Shang, G. Yu, “Noncontact diffuse correlation spectroscopy for noninvasive deep tissue blood flow measurement”, J. Biomed. Opt. 17, 010502 (2012) |
| - | Y. Shang, L. Chen, M. Toborek, and G. Yu, "Diffuse optical monitoring of repeated cerebral ischemia in mice," Optics Express, 19(21), 20301-20315 (2011) |
| - | D. Irwin, L. Dong, Y. Shang, R. Cheng, M. Kudrimoti, S.D. Stevens, and G. Yu, "Influences of tissue absorption and scattering on diffuse correlation spectroscopy blood flow measurements," Biomedical Optics Express 2, 1969-1985 (2011). |
| - | Y. Shang, R. Cheng, L. Dong, S.J. Ryan, S.P. Saha, and G. Yu, "Cerebral monitoring during carotid endarterectomy using near-infrared diffuse optical spectroscopies and electroencephalogram", Physics in Medicine and Biology 56(10), 3015-32 (2011). |
| - | G. Yu, Y. Shang, Y. Zhao, R. Cheng, L. Dong, and S.P. Saha, "Intraoperative evaluation of revascularization effect on ischemic muscle hemodynamics using near-infrared diffuse optical spectroscopies," Journal of Biomedical Optics 16(2), 027004 (2011) |
| - | N. Munk, B. Symons, Y. Shang, R. Cheng and G. Yu, "Noninvasively measuring the hemodynamic effects of massage on skeletal muscle: A novel hybrid near-infrared diffuse optical instrument," Journal of bodywork and movement therapies 16(1), 22-28 (2012) |
| - | Y. Shang, T. B. Symons, T. Durduran, A. G. Yodh, and G. Yu, "Effects of muscle fiber motion on diffuse correlation spectroscopy blood flow measurements during exercise," Biomedical Optics Express 1, 500-511 (2010) |
| - | Y. Shang, Y. Zhao, R. Cheng, L. Dong, D. Irwin, and G. Yu, "Portable optical tissue flow oximeter based on diffuse correlation spectroscopy," Optics Letters 34, 3556-3558 (2009) |
| - | Y. Shang, L. Peng, and J. Bai, "Effect of muscle loadings on femur remodeling simulation using orthotropic algorithm," Journal of Tsinghua University 49(6), 892-895 (2009) |
| - | Y. Shang, J. Bai and L. Peng, "The effects of the spatial influence function on orthotropic femur remodeling," Proceedings of the Institution of Mechanical Engineers Part H - Journal of Engineering in Medicine 222 (5), 601-609 (2008) |
| - | Y. Shang, L. Peng, J. Liu, Y. Wan, Y. Li and J. Bai, "The finite element analysis of femur and tibia for homogeneous materials and CT gray value based materials," Chinese Journal of Biomedical Engineering 27(5), 722-727 (2008) |
| - | L. Peng, H. Wang, J. Liu, Y. Shang and J. Bai, "A method to evaluate femoral bone mass in rats with CT numbers," Journal of Biomedical Engineering 25(2), 231-234 (2008) |
| - | Y. Shang, J. Bai, L. Peng and J. Lau, "Comparison of methods for determining orthotropic axes in 3D femur remodeling," Progress in Natural Science 17 (12), 1405-1411 (2007) |
| - | Y. Shang and J. Bai, "Mathematical model of skeletal muscle force produced by electrical stimulation," International Journal of Biomedical Engineering 30 (2), 77-80 (2007) |
| - | L. Peng, Y. Shang, J. Liu, Y. Wan, Y. Li and J. Bai, "Research on finite element analysis to evaluate the femoral mechanical properties of tail-suspended rats," Chinese Journal of Biomedical Engineering 26 (3), 421-425 (2007) |
| - | L. Peng, Y. Shang, Y. Liang, B. Sun, G. Wang and J. Bai, "Preliminary research on effects of percutaneous muscular electrical stimulation against bone loss in tail-suspended rats," Space Medicine & Medical Engineering 20 (1), 7-10 (2007) |
| - | L. Peng, Y. Shang, Y. Wan, Y. Li, Y. Liang and J. Bai, "Precision comparison of DXA, mechanical testing and mineral content in the evaluation of rat femoral properties," Beijing Biomedical Engineering 26 (1), 65-67 (2007) |
| - | X. Zhu, Y. Hou and Y. Shang, "Effect of micro-cracks of trabecular bone on the mechanical properties of cancellous bone," Chinese Journal of Biomedical Engineering 23 (3), 286-288 (2004) |
| - | X. Zhu, Y. Hou and Y. Shang, "Effect of microstructure and material properties on the mechanical properties of cancellous bone," Chinese Journal of Biomedical Engineering 23 (2), 134-138 (2004) |
| - | X. Zhu, Y. Hou and Y. Shang, "Investigation on trabecular bone rigidity based on homogenization theory," Journal of Jilin University (Engineering and Technology Edition) 34 (2), 169-173 (2004) |
| Selected presentations/publications in conferences/proceedings (in chronological order) | |
| - | Y. Shang, R. Cheng, L. Dong, S. J. Ryan, S. P. Saha, G. Yu, “Comparison of diffuse optical spectroscopies and electroencephalogram for cerebral monitoring during carotid endarterectomy”, OSA Biomedical Optics (BIOMED), Miami, FL, 2012 |
| - | Y. Shang, K. Gurley, B. Symons, D. Long, J. Lee, R. Srikuea, L. Crofford, C. Peterson, G. Yu, “Diffuse optical detecting hemodynamic responses during fatiguing exercise in women with fibromyalgia”, OSA Biomedical Optics (BIOMED), Miami, FL, 2012 |
| - | Y. Shang, L. Chen, M. Toborek, G. Yu, “Hemodynamic monitoring of repeated cerebral ischemia in mice using diffuse optical spectroscopies”, OSA Biomedical Optics (BIOMED), Miami, FL, 2012 |
| - | K. Gurley, Y. Shang, G. Yu, “Noninvasive Optical Quantification of Absolute Blood Flow and Oxygen Consumption Rate in Exercising Skeletal Muscle”, OSA Biomedical Optics (BIOMED), Miami, FL, 2012 |
| - | R. Cheng, Y. Shang, G. Yu, “Noninvasive Optical Detection of Spontaneous Low Frequency Oscillations in Cerebral Blood Flow”, OSA Biomedical Optics (BIOMED), Miami, FL, 2012 |
| - | G. Yu, K. Gurley, Y. Shang, “DCS Measurement Can Be Gated Via Monitoring Muscle Movement to Derive Accurate Blood Flow in Exercising Muscle”, OSA Biomedical Optics (BIOMED), Miami, FL, 2012 |
| - | Y. Lin, L. He, Y. Shang, G. Yu, “Noncontact diffuse correlation spectroscopy probe for deep tissue blood flow measurement”, OSA Biomedical Optics (BIOMED), Miami, FL, 2012 |
| - | L. He, Y. Lin, Y. Shang, and G. Yu, “Using few-mode fiber to improve the signal-to-noise ratio of DCS flow-oximeter measurements”, OSA Biomedical Optics (BIOMED), Miami, FL, 2012 |
| - | L. Dong, D. Irwin, Y. Shang, R. Cheng, M. Kudrimoti, S. D. Stevens, and G. Yu, “Influences of Tissue Optical Properties on Diffuse Correlation Spectroscopy Blood Flow Measurements”, OSA Biomedical Optics (BIOMED), Miami, FL, 2012 |
| - | L. Dong, M. Kudrimoti, R. Cheng, Y. Shang, E. L. Johnson, S. D. Stevens, B. J. Shelton, G. Yu, “Noninvasive diffuse optical monitoring of hemodynamic changes in head and neck tumor during radiation delivery”, OSA Biomedical Optics (BIOMED), Miami, FL, 2012 |
| - | G. Yu, Y. Shang, “Near-infrared Diffuse Optical Spectroscopies for Measurement of Deep Tissue Blood Flow, Oxygenation and Metabolism”, IEEE Biomedical Instrumentation for the Future of Instrumentation International Workshop (FIIW), Oak Ridge National Laboratory, Oak Ridge, TN, 2011 |
| - | Y. Shang, R. Cheng, L. Dong, S. P. Saha, and G. Yu, "Diffuse Optical Detection of Cerebral Ischemia During Carotid Endarterectomy," Conference on Biomedical Optics and 3D Imaging, Technical Digest (CD) (Optical Society of America, 2010), paper BSuD78 |
| - | Y. Shang, Y. Zhao, R. Cheng, L. Dong, D. Irwin, K. R. Swartz, S. S. Salles, and G. Yu, "Diffuse Optical Spectroscopies for Evaluation of Muscle Hemodynamic Enhancements by Electrical Stimulation," Conference on Biomedical Optics and 3D Imaging, Technical Digest (CD) (Optical Society of America, 2010), paper BSuD80 |
| - | G. Yu, Y. Shang, Y. Zhao, R. Cheng, L. Dong, D. Irwin, and S.P. Saha .Portable Optical Tissue Flow Oximeter for Evaluation of Revascularization Effect on Ischemic Muscle Hemodynamics. Conference on Biomedical Optics and 3D Imaging, Technical Digest (CD) (Optical Society of America, 2010), paper JMA90 |
| - | R. Cheng, Y. Shang, D. Kameny, D. Hayes Jr, and G. Yu, "Noninvasive Optical Evaluation of Cerebral Autoregulation in Patients with Obstructive Sleep Apnea," Conference on Biomedical Optics and 3D Imaging, Technical Digest (CD) (Optical Society of America, 2010), paper JMA103 |
| - | S. Cheng, J. Bai, Y. Shang, and L. Peng, "The Simulation of Bone Loss Due to Weightlessness and Bone Recovery Using Finite Element Method," The 4th International Conference on Bioinformatics and Biomedical Engineering (iCBBE 2010), Chengdu, China |
| - | Y. Shang, J. Bai and L. Peng, "The differences of mechanical properties of femur using two material assignment methods based on CT data," 2008 International Conference on BioMedical Engineering and Informatics (BMEI2008), 557-560 (2008) |
| - | Y. Shang, L. Peng and J. Bai, "A three-dimensional orthotropic adaptation algorithm for femur remodeling," World Congress on Medical Physics and Biomedical Engineering 2006 (WC2006), IFMBE Proceedings 14/5, 3038-3040 (2006) |
|
Conference
abstracts (in
chronological
order). |
|
| - | K. Gurley, Y. Shang, G. Yu, “Noninvasive optical quantification of absolute blood flow and oxygen consumption rate in exercising skeletal muscle”, 59th Annual Meeting of American College of Sports and Medicine (ACSM), San Francisco, CA, 2012 |
| - | Y. Shang, R. Cheng, L. Dong, S.J. Ryan, S.P. Saha, and G. Yu, "Use of Diffuse Optical Spectroscopies and Electroencephalogram for Cerebral Monitoring During Carotid Endarterectomy", ECI (Engineering Conference International) conference Advances in Optics for Biotechnology, Medicine and Surgery XII, Naples, FL, USA (2011). |
| - | Y. Shang, Y. Zhao, R. Cheng, L. Dong, S.P. Saha, and G. Yu, "Diffuse Optical Evaluation of Revascularization Effect on Ischemic Muscle Hemodynamics in Lower Extremities", ECI (Engineering Conference International) conference Advances in Optics for Biotechnology, Medicine and Surgery XII, Naples, FL, USA (2011). |
| - | D. Irwin, L. Dong, Y. Shang, R. Cheng, M. Kudrimoti, G. Yu, “Influences of Tissue Absorption and Scattering on Diffuse Correlation Spectroscopy Blood Flow Measurements”, Engineering Conferences International (ECI) conference Advances in Optics for Biotechnology, Medicine and Surgery, Naples, FL, 2011 |
| - | Y. Shang, R. Cheng, L. Dong, S.P. Saha, G. Yu, "Detection of Cerebral Ischemia during Carotid Dendarterectomy using Near-Infrared Diffuse Optics Spectroscopies," 52nd Annual World Congress of the International College of Angiology, Lexington, KY, USA (2010). |
| - | R. Cheng, Y. Shang, G. Yu, S.P. Saha, "Intraoperative Evaluation of Revascularization Effect on Ischemic Muscle Hemodynamics Using Near-infrared Diffuse Optical Spectroscopies," 52nd Annual World Congress of the International College of Angiology, Lexington, KY, USA (2010). |
| - | N. Munk, T.B. Symons, Y. Shang, R. Cheng, G. Yu, "Measuring the Effects of Massage on Skeletal Muscle Blood Flow: A Novel Hybrid Near-Infrared Diffuse Optical Instrument," Conference of Highlighting Massage Therapy in Complementary and Integrative Medicine (CIM) Research, Seattle, Washington, USA (2010). |
| - | Y. Shang, Y. Zhao, R. Cheng, L. Dong, S.P. Saha and G. Yu, "Intraoperative assessment of acute revascularization effect on ischemic muscle perfusion and oxygenation," The International Society for Optical Engineering (SPIE) Photonics West, San Francisco, CA, USA (2010) (oral presentation) |
| - |
Y. Shang,
Y. Zhao, R.
Cheng, D. Irwin,
L. Dong, K. R.
Swartz, S.
Salles, and G.
Yu,
"Noninvasive
Assessment of
Muscle
Hemodynamic
Enhancement by
Electrical
Stimulation
Using Diffuse
Optical
Spectroscopies,"
Fall Annual
Meeting of the
Biomedical
Engineering
Society,
Pittsburgh, PA,
USA, (2009)
(oral
presentation) |
| - | R. Cheng, Y. Shang, Y. Zhao, L. Dong, D. Hayes Jr. , and G. Yu, "Noninvasive Diffuse Optical Evaluation of Cerebral Autoregulation" Fall Annual Meeting of the Biomedical Engineering Society, Pittsburgh, PA, USA, (2009) |
| - | Y. Zhao, Y. Shang, R. Cheng, L. Dong, S. P. Saha, and G. Yu, "Diffuse Optical Monitoring of Revascularization Effect on Skeletal Muscle Perfusion," Fall Annual Meeting of the Biomedical Engineering Society, Pittsburgh, PA, USA (2009) |
| Research Support | ||
| AHA (America Heart Association) Great Rivers Affiliate Postdoctoral Fellowship #11POST7360020 | 7/1/2011-6/30/2013 | PI |
| Development of diffuse optical spectroscopies for monitoring cerebral blood flow and oxygenation in mouse stroke model | ||
| To adapt and use a diffuse optical device for monitoring of cerebral blood flow and oxygenation in mice undergoing repeated transient forebrain ischemia (TFI), which may assist in understanding the TFI mechanism in protection/promotion of stroke. | ||
| R01 CA149274-01 (NIH) | 7/1/2010-6/30/2015 | Participant |
| Diffuse Optical Monitoring of Head and Neck Tumor Therapy | ||
| To develop and test a low-cost clinical-level optical instrument that can quickly assess head/neck tumor hemodynamic/metabolic status and responses to radiation therapy in early stages of cancer therapy. | ||
| R21-AG-034279 (NIH) | 9/15/2009-8/31/2011 | Participant |
| Contribution of Altered Muscle Hemodynamics to Fatigability in Older Persons with and without Fibromyalgia | ||
| To identify defects in muscle physiology of older fibromyalgia (FM) patients, as well as older healthy but fatigable individuals, which may contribute to this symptom. | ||
| AHA (America Heart Association) BGIA #2350015 | 7/1/2009-6/30/2011 | Participant |
|
A Portable
Optical Flow-Oximeter
for Assessment
of Cerebral
Hemodynamics and
Metabolism
during
Obstructive
Sleep Apnea
(OSA) |
||
|
To develop a
high-throughput,
portable, and
easy-to-use
optical device for simultaneous
monitoring
multiple
cerebral
physiological
parameters
during sleep in
patients with
obstructive
sleep apnea
(OSA). |
||