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ebox cannonical xping

A non-canonical E-box within the MyoD core enhancer is necessary for circadian expression in skeletal muscle

Xiping Zhang, Samir P. Patel, John J. McCarthy, Alexander G. Rabchevsky, David J. Goldhamer and Karyn A. Esser Click to download

Featured McCarthy SatCells

Effective fiber hypertrophy in satellite cell-depleted skeletal muscle

John J. McCarthy, Jyothi Mula, Mitsunori Miyazaki, Rod Erfani, Kelcye Garrison, Amreen B. Farooqui, Ratchakrit Srikuea, Benjamin A. Lawson, Barry Grimes, Charles Keller, Gary Van Zant, Kenneth S. Campbell, Karyn A. Esser, Esther E. Dupont-Versteegden and Charlotte A. Peterson Click to download

featured mits mtor

Early activation of mTORC1 in response to mechanical overload is independent of PI3K/Akt signaling

Miyazaki M, McCarthy JJ, Fedele MJ, Esser KA. Early activation of mTORC1 in response to mechanical overload is independent of PI3K/Akt signaling. J Physiol. 2011 Feb 7. [Epub ahead of print] PubMed PMID: 21300751Click to download

featured circadian xping

CLOCK and BMAL1 regulate MyoD and are necessary for maintenance of skeletal muscle phenotype and function

Andrews JL, Zhang X, McCarthy JJ, McDearmon EL, Hornberger TA, Russell B, Campbell KS, Arbogast S, Reid MB, Walker JR, Hogenesch JB, Takahashi JS, Esser KA. CLOCK and BMAL1 regulate MyoD and are necessary for maintenance of skeletal muscle phenotype and function. Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):19090-5. Epub 2010 Oct [...]

Welcome from the Director

The Center for Muscle Biology was formally established in June 2008 to support and integrate basic, clinical and translational research on striated and smooth muscle throughout the University of Kentucky.

Center Members have active research programs in multiple areas of muscle biology including aging, congestive heart failure, sepsis, metabolic disease, arthritis and cancer.

Please investigate the links on this site and contact us if you would like more information, or better, come and see us. We would be delighted to show you around and get better acquainted.
 Karyn Esser, Center Director
Karyn A. Esser, PhD
Director
Center for Muscle Biology
karyn.esser@uky.edu

Interesting Read

FoxO1 induces apoptosis in skeletal myotubes in a DNA-binding-dependent manner

McLoughlin, T.J., S.M. Smith, H. Wang, T.G. Unterman and K.A.Esser.  FoxO1 induces apoptosis in myotubes in a DNA binding dependent manner. Am.J.Physiol: Cell, Jun 24. Epub, PMID: 19553561Click to download

Mechanotransduction and the regulation of protein synthesis in skeletal muscle

Hornberger TA, Esser KA. Mechanotransduction and the regulation of protein synthesis in skeletal muscle. Proc Nutr Soc. 2004 May;63(2):331-5. Review. PubMed PMID: 15294051Click here to download