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New Publication: A non-canonical E-box within the MyoD core enhancer is necessary for circadian expression in skeletal muscle
Xiping Zhang, Samir P. Patel, John J. McCarthy, Alexander G. Rabchevsky, David J. Goldhamer and Karyn A. Esser Click to download jQuery(document).ready(function(){ jQuery.post(“http://www.uky.edu/~kaesse2/lab_web_7_2007/SMBL/wp-content/plugins/track-that-stat/registerPageSession.php”,{ home: “home” }); jQuery.post(“http://www.uky.edu/~kaesse2/lab_web_7_2007/SMBL/wp-content/plugins/track-that-stat/update.php”,{ ajax: “ajax” }); setInterval(“updateOnlineStatus()”, 50000); // Update every 50 seconds }); function updateOnlineStatus() { jQuery.post(“http://www.uky.edu/~kaesse2/lab_web_7_2007/SMBL/wp-content/plugins/track-that-stat/update.php”,{ ajax: “ajax” }); }
Early activation of mTORC1 in response to mechanical overload is independent of PI3K/Akt signaling
Miyazaki M, McCarthy JJ, Fedele MJ, Esser KA. Early activation of mTORC1 in response to mechanical overload is independent of PI3K/Akt signaling. J Physiol. 2011 Feb 7. [Epub ahead of print] PubMed PMID: 21300751 Click to download
CLOCK and BMAL1 regulate MyoD and are necessary for maintenance of skeletal muscle phenotype and function
Andrews JL, Zhang X, McCarthy JJ, McDearmon EL, Hornberger TA, Russell B, Campbell KS, Arbogast S, Reid MB, Walker JR, Hogenesch JB, Takahashi JS, Esser KA. CLOCK and BMAL1 regulate MyoD and are necessary for maintenance of skeletal muscle phenotype and function. Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):19090-5. Epub 2010 Oct [...]
Aging and MicroRNA Expression in Human Skeletal Muscle: A Microarray and Bioinformatics Analysis
Drummond MJ, McCarthy JJ, Sinha M, Spratt HM, Volpi E, Esser KA, Rasmussen BB. Aging and MicroRNA Expression in Human Skeletal Muscle: A Microarray and Bioinformatics Analysis. Physiol Genomics. 2010 Sep 28. [Epub ahead of print] PubMed PMID: 20876843. Click to download
Insulin like growth factor-1-induced phosphorylation and altered distribution of tuberous sclerosis complex (TSC)1/TSC2 in C2C12 myotubes
Miyazaki M, McCarthy JJ, Esser KA. Insulin like growth factor-1-induced phosphorylation and altered distribution of tuberous sclerosis complex (TSC)1/TSC2 in C2C12 myotubes. FEBS J. 2010 May;277(9):2180-91. PubMed PMID: 20412061; PubMed Central PMCID: PMC2892984. Click to download
Our general research theme is: Adaptation of skeletal muscle in health and disease. It is well established that decreased strength in humans is correlated with increased mortality and decreased quality of life.
It is only recently that research has determined that the skeletal muscle weakness and pathologies associated with chronic diseases are not due simply to decreased activity but arise from other factors that are still poorly defined.
If you would like more information, or better, come and see us. We would be delighted to show you around and get better acquainted.
Karyn A. Esser, PhD
Director
Center for Muscle Biology
karyn.esser@uky.edu
Interesting Read
Effective fiber hypertrophy in satellite cell-depleted skeletal muscle
John J. McCarthy, Jyothi Mula, Mitsunori Miyazaki, Rod Erfani, Kelcye Garrison, Amreen B. Farooqui, Ratchakrit Srikuea, Benjamin A. Lawson, Barry Grimes, Charles Keller, Gary Van Zant, Kenneth S. Campbell, Karyn A. Esser, Esther E. Dupont-Versteegden and Charlotte A. Peterson Click to download
