All citations in PubMed
Hippocampal calcium dysregulation at the nexus of diabetes and brain aging. Thibault O, Anderson KL, Demoll C, Brewer LD, Landfield PW, Porter NM. Eur J Pharmacol. 2013 Jul 17. doi:pii: S0014-2999(13)00546-3. 10.1016/j.ejphar.2013.07.024.
Effect of high-fat-diet on metabolic indices, cognition, and neuronal physiology in aging F344 rats. Pancani T., Anderson K.L., Brewer L.D., Kadish I., Demoll C., Lanfield P.W., Blalock E.M., Porter N.M., Thibault O. (2013). Neurobiol Aging. 2013 Mar 29.
Long-term pioglitazone improves learning and attenuates pathological markers in a mouse model of AD. Searcy J.L., Phelps J.T., Pancani T., Kadish I., Popovich J., Anderson K.L., Beckett T.L., Murphy M.P., Chen K.-C., Blalock E.M., Porter N.M., Landfield P.W., Thibault O. (2012). Journal of Alzheimer’s Disease, 2012;30(4):943-61.
Reduction in neuronal L-type calcium channel activity in a double knock-in mouse model of Alzheimer’s disease.Thibault O., Pancani T., Landfield P.W., Norris C.M. (2012). Biochimica et Biophysica Acta – Molecular Basis of Disease 2012, 546–549.
Reversal of glial and neurovascular markers of unhealthy brain aging by exercise in middle-aged female mice. Latimer C.S., Searcy J.L., Bridges M.T., Brewer L.D., Popović J., Blalock E.M., Landfield P.W., Thibault O., and Porter N.M. (2011). PLoS ONE 6(10): e26812. doi:10.1371/journal.pone.0026812.
Imaging of a glucose analog, calcium and NADH in neurons and astrocytes: dynamic responses to depolarization and sensitivity to pioglitazone. Pancani T., Anderson K.L., Porter N.M., Thibault O. (2011). doi:10.1016/j.ceca.2011.09.002 Cell Calcium 50, 548-558.
Disrupting Function of FK506-Binding Protein 1b/12.6 Induces the Ca2+-Dysregulation Aging Phenotype in Hippocampal Neurons. Gant J.C., Chen K.-C., Norris C.M., Thibault O., Blalock E.M., Porter N.M., and Landfield P.W. (2011). J. Neurosci. 13(5):1693-1703. PMID:21289178
Effects of long-term pioglitazone treatment on peripheral and central markers of aging. Blalock EM, Phelps JT, Pancani T, Searcy JL, Anderson KL, Gant JC, Popovic J, Avdiushko MG, Cohen DA, Chen KC, Porter NM, Thibault O. PLoS One. 2010 Apr 29;5(4):e10405.
Aging-related gene expression in hippocampus proper compared with dentate gyrus is selectively associated with metabolic syndrome variables in rhesus monkeys. Blalock EM, Grondin R, Chen KC, Thibault O, Thibault V, Pandya JD, Dowling A, Zhang Z, Sullivan P, Porter NM, Landfield PW.
J Neurosci. 2010 Apr 28;30(17):6058-71.
PMID: 20427664 [PubMed - indexed for MEDLINE] Free Article
Distinct modulation of voltage-gated and ligand-gated Ca2+ currents by PPAR-gamma agonists in cultured hippocampal neurons. Pancani T, Phelps JT, Searcy JL, Kilgore MW, Chen KC, Porter NM, Thibault O. J Neurochem. 2009 Jun;109(6):1800-11. Epub 2009 May 11.
Hippocampal and cognitive aging across the lifespan: a bioenergetic shift precedes and increased cholesterol trafficking parallels memory impairment. Kadish I, Thibault O, Blalock EM, Chen KC, Gant JC, Porter NM, Landfield PW. J Neurosci. 2009 Feb 11;29(6):1805-16.
Decreased number of interneurons and increased seizures in neuropilin 2 deficient mice: implications for autism and epilepsy. Gant JC, Thibault O, Blalock EM, Yang J, Bachstetter A, Kotick J, Schauwecker PE, Hauser KF, Smith GM, Mervis R, Li Y, Barnes GN. Epilepsia. 2009 Apr;50(4):629-45. Epub 2008 Jul 24.
Hippocampal 'zipper' slice studies reveal a necessary role for calcineurin in the increased activity of L-type Ca(2+) channels with aging. Norris CM, Blalock EM, Chen KC, Porter NM, Thibault O, Kraner SD, Landfield PW. Neurobiol Aging. 2010 Feb;31(2):328-38. Epub.
Action potential throughput in aged rat hippocampal neurons: regulation by selective forms of hyperpolarization. Gant JC, Thibault O.
Neurobiol Aging. 2009 Dec;30(12):2053-64. Epub 2008 Mar 25. PMID: 18367293 [PubMed - indexed for MEDLINE] Free PMC Article
Expansion of the calcium hypothesis of brain aging and Alzheimer's disease: minding the store.Thibault O, Gant JC, Landfield PW. Aging Cell. 2007 Jun;6(3):307-17. Epub 2007 Apr 26. Review.
Increased vulnerability of hippocampal neurons with age in culture: temporal association with increases in NMDA receptor current, NR2A subunit expression and recruitment of L-type calcium channels. Brewer LD, Thibault O, Staton J, Thibault V, Rogers JT, Garcia-Ramos G, Kraner S, Landfield PW, Porter NM. Brain Res. 2007 Jun 2;1151:20-31. Epub 2007 Mar 12.
Hippocampal expression analyses reveal selective association of immediate-early, neuroenergetic, and myelinogenic pathways with cognitive impairment in aged rats. Rowe WB, Blalock EM, Chen KC, Kadish I, Wang D, Barrett JE, Thibault O, Porter NM, Rose GM, Landfield PW. J Neurosci. 2007 Mar 21;27(12):3098-110.
Electrophysiological mechanisms of delayed excitotoxicity: positive feedback loop between NMDA receptor current and depolarization-mediated glutamate release. Norris CM, Blalock EM, Thibault O, Brewer LD, Clodfelter GV, Porter NM, Landfield PW. J Neurophysiol. 2006 Nov;96(5):2488-500. Epub 2006 Aug 16.
Chronic 1alpha,25-(OH)2 vitamin D3 treatment reduces Ca2+ -mediated hippocampal biomarkers of aging. Brewer LD, Porter NM, Kerr DS, Landfield PW, Thibault O. Cell Calcium. 2006 Sep;40(3):277-86. Epub 2006 Jun 14.
Early and simultaneous emergence of multiple hippocampal biomarkers of aging is mediated by Ca2+-induced Ca2+ release. Gant JC, Sama MM, Landfield PW, Thibault O. J Neurosci. 2006 Mar 29;26(13):3482-90.
The neurobiology of aging. Kelly KM, Nadon NL, Morrison JH, Thibault O, Barnes CA, Blalock EM. Epilepsy Res. 2006 Jan;68 Suppl 1:S5-20. Epub 2005 Dec 28. Review.
Sustained Ca2+-induced Ca2+-release underlies the post-glutamate lethal Ca2+ plateau in older cultured hippocampal neurons. Clodfelter GV, Porter NM, Landfield PW, Thibault O. Eur J Pharmacol. 2002 Jul 5;447(2-3):189-200.
Preface. Ca2+ and neuronal pathology. Verkhratsky A, Landfield PW, Thibault O. Eur J Pharmacol. 2002 Jul 5;447(2-3):115-7.
Group I metabotropic glutamate receptor inhibition selectively blocks a prolonged Ca(2+) elevation associated with age-dependent excitotoxicity. Attucci S, Clodfelter GV, Thibault O, Staton J, Moroni F, Landfield PW, Porter NM. Neuroscience. 2002;112(1):183-94.
Elevated postsynaptic [Ca2+]i and L-type calcium channel activity in aged hippocampal neurons: relationship to impaired synaptic plasticity.
Thibault O, Hadley R, Landfield PW. J Neurosci. 2001 Dec 15;21(24):9744-56.
Expression of alpha 1D subunit mRNA is correlated with L-type Ca2+ channel activity in single neurons of hippocampal "zipper" slices.
Chen KC, Blalock EM, Thibault O, Kaminker P, Landfield PW. Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):4357-62.
Calcium dysregulation in neuronal aging and Alzheimer's disease: history and new directions.Thibault O, Porter NM, Chen KC, Blalock EM, Kaminker PG, Clodfelter GV, Brewer LD, Landfield PW. Cell Calcium. 1998 Nov-Dec;24(5-6):417-33. Review. No abstract available.
Calcium channel density and hippocampal cell death with age in long-term culture. Porter NM, Thibault O, Thibault V, Chen KC, Landfield PW. J Neurosci. 1997 Jul 15;17(14):5629-39.
Aging changes in voltage-gated calcium currents in hippocampal CA1 neurons. Campbell LW, Hao SY, Thibault O, Blalock EM, Landfield PW.
J Neurosci. 1996 Oct 1;16(19):6286-95.
Increase in single L-type calcium channels in hippocampal neurons during aging.Thibault O, Landfield PW. Science. 1996 May 17;272(5264):1017-20.
Single-channel and whole-cell studies of calcium currents in young and aged rat hippocampal slice neurons.Thibault O, Mazzanti ML, Blalock EM, Porter NM, Landfield PW. J Neurosci Methods. 1995 Jun;59(1):77-83.
Low Ba2+ and Ca2+ induce a sustained high probability of repolarization openings of L-type Ca2+ channels in hippocampal neurons: physiological implications.Thibault O, Porter NM, Landfield PW. Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):11792-6.
Mechanisms of neuronal death in brain aging and Alzheimer's disease: role of endocrine-mediated calcium dyshomeostasis. Landfield PW, Thibault O, Mazzanti ML, Porter NM, Kerr DS. J Neurobiol. 1992 Nov;23(9):1247-60. Review.
Hippocampal glucocorticoid receptor activation enhances voltage-dependent Ca2+ conductances: relevance to brain aging. Kerr DS, Campbell LW, Thibault O, Landfield PW. Proc Natl Acad Sci U S A. 1992 Sep 15;89(18):8527-31.
Antagonism of NMDA receptors impairs acquisition but not retention of olfactory memory. Staubli U, Thibault O, DiLorenzo M, Lynch G.
Behav Neurosci. 1989 Feb;103(1):54-60.
Long-lasting physiological effects of bath applied N-methyl-D-aspartate.Thibault O, Joly M, Muller D, Schottler F, Dudek S, Lynch G.
Brain Res. 1989 Jan 2;476(1):170-3.
Chronic administration of a thiol-proteinase inhibitor blocks long-term potentiation of synaptic responses. Staubli U, Larson J, Thibault O, Baudry M, Lynch G. Brain Res. 1988 Mar 15;444(1):153-8.