Graduate School Bulletin - Spring 2006

CLINICAL SCIENCES

Graduate study in the clinical sciences is designed to prepare candidates for advanced study and research careers in academics, industry and pharmaceutical laboratories. Initial focus in the program will concentrate on reproductive laboratory sciences and hematology with special emphasis in transplantation immunology.

Admission Requirements

Admission to the graduate program is competitive and is based upon academic background, professional recommendations, performance on the Graduate Record Examination (GRE), experience and, when possible, personal interviews. Students should have completed an undergraduate degree in clinical laboratory sciences; however students will be considered who have degrees in biology, biochemistry, biomedical science, or chemistry. It is recommended that students have completed undergraduate courses in biological sciences, chemistry, and clinical laboratory sciences.

Students will have the opportunity to learn and study with a faculty assembled to deliver this program. Subject areas include fertility, reproductive immunology, andrology, signal transduction, disease mechanisms such as cancer with an emphasis in the leukemias and lymphomas, drug development and experimental therapeutics, hematopoiesis, stem cell biology, and quality assurance and control. The program of study stresses an interdepartmental approach both in the selection of courses and in the pursuit of research. Students are expected to participate in graduate seminars, journal clubs, and research seminars; to interact with visiting scholars, both domestic and international; and to present the results of their research at local, national and international conferences.

Master of Science

The Master of Science degree in Clinical Sciences consists of a track in reproductive laboratory science (RLS) and a track in hematology/transplantation science. A minimum of 30 credit hours is required for the RLS track and includes 11-16 credit hours in math and science followed by 19-21 hours in RLS courses specific for the discipline. All students must complete a research course and clinical practica in andrology and assisted reproductive technology (ART). A total of 37-38 credit hours are required for the hematology/transplantation science track, including a 19-credit hour core and 18-19 hours of courses specific for the discipline. The RLS track is non-thesis, requiring research and both an oral and written research presentation. Both thesis and non-thesis options are offered for the hematology/transplantation track. Selected courses for both tracks are offered via distributive learning. Non-thesis projects are selected by the student in consultation with their Master's committee members. The Thesis option involves basic/applied research under a mentor in the student's scholarly area of interest.

Degree Requirements for Reproductive Laboratory Science track

Math and Science Courses (11-16 credit hours) Statistics (3-4)
Physiology or Pathophysiology (3-4)
Science courses (3-6) depending on background

CSC 528 Laboratory Techniques (2); required for students not having clinical laboratory experience
CSC 615 Reproductive Laboratory Science (1)
CSC 616 Andrology (1)
CSC 617 Reproductive Microbiology and Immunology (1)
CSC 618 Laboratories in Andrology, Reproductive Microbiology & Immunology (1)
CSC 621 Embryology and ART (3)
CSC 624 Gamete & Embryo Cryopreservation (2)
CSC 625 Management, Policy, Ethical & Legal Issues in ART (2)
CSC 625 Andrology Clinical Practicum (2)
CSC 627 ART Clinical Practicum (3)
CSC 628 RLS Seminar (1)
CSC 630 RLS Research (3-5)

Total credits for the Master of Clinical Sciences, RLS track, is 30-35.

Degree Requirements for Hematology/Transplantation Sciences Track

Core Courses (19 credit hours)
CSC 600 Human Pathophysiology (4)
CSC 601 Health Care Policy and Ethics (3)
CSC 602 Clinical Sciences Seminar (taken twice for credit) (1)
CSC 603 Quality Assurance and Laboratory Regulations (4)
CSC 604 Research Methods for the Clinical Sciences (3)
CSC 605 Epidemiology and Biostatistics or
CSC 606 Advanced Laboratory Statistics & Administrative Analysis (3)

Hematology/Transplant Science (18 credit hours)
CSC 670 Histocompatability & Immunogenetics (3)
CSC 671 Molecular Immunopathogenesis (3)
CSC 672 Transplantation Science (3)
CSC 673 Flow Cytometry (3)
CSC 674 Hemopoiesis (3)
CSC 675 Myeloproliferative Disorders (3)
CSC 676 Advanced Hemostasis (3)
CSC 677 Erythrocyte Disorders (3)
CSC 690 Clinical Sciences Thesis Research (0-6)

Total Credits for the Master's Degree, Hematology/Transplantation Science Track, is 37 or 38.

Doctor of Science

The Clinical Sciences doctoral program is designed to produce both academic leaders and researchers in the area of hematology with an emphasis in transplantation science for those individuals with a background in the biological and clinical sciences. The core curriculum is the framework upon which the student builds a foundation for scholarship in the selected area of study. An in-depth course in the biosynthesis, structure and function of macromolecules lays the groundwork for genetic therapy applications and intensive study in hematology and transplantation science.

The program brings together the educational and research expertise of our University faculties in the College of Health Sciences and the College of Medicine. This collaboration will enable graduates to promote academic and clinical leadership in addressing health-related basic research and clinical issues that will increase in importance during the coming decade.

Integral to the scholarship of discovery is a thorough understanding of the analysis and interpretation of data. Course work in the principles, applications and implementation of research theory is an essential component of the doctoral program and requisite to the preparation of scholars as consumers of and contributors to intellectual investigation. These courses in conjunction with the research apprenticeship will prepare students for independent scholarship.

Degree Requirements

(Hematology/Transplantation Science only)

Core Courses (35-40 credit hours)
STA 570 Statistics (4)
STA 672 Design & Analysis of Experiments (2-6)
CSC 602 Clinical Sciences Seminar (taken twice for credit) (1)
CSC 772 Gene Therapy (3)
CSC 774 Biosynthesis, Structure & Function of Macro-
molecules (4)
CSC 787 Teaching Apprenticeship (2)
CSC 789 Research Apprenticeship (2)
CSC 790 Clinical Sciences Dissertation Research (taken two
successive semesters) (9)

Individualized Course of Study (9 credit hours)
(Hematology/Transplantation Science only)
CSC 776 Molecular Genetics & Chromosome Analysis of
Hematopoietic Disorders (3)
CSC 777 Hematopoietic Stem Cell and Bone Marrow
Transplantation: Nontraditional Applications (3)
CSC 778 Clinical Molecular Cytometry (3)

Additional Requirements
Oral and/or Written Comprehensive Examination/Qualifying Exam
Post Qualifying Exam Residency (two semesters)
Dissertation
The Final Examination

Inquiries regarding admission to the Clinical Sciences Graduate Program should be addressed to:

Professor Linda S. Gorman, Director of Graduate Studies
Department of Clinical Sciences
University of Kentucky College of Health Sciences
E-mail: lsgorm0@uky.edu

GRADUATE COURSES

CSC 528 LABORATORY TECHNIQUES FOR NON-CLS STUDENTS (2)

CSC 600 HUMAN PATHOPHYSIOLOGY (4)

CSC 601 HEALTH CARE POLICY AND ETHICS (3)

CSC 602 CLINICAL SCIENCES SEMINAR (1)

CSC 603 QUALITY ASSURANCE AND LABORATORY REGULATIONS (4)

CSC 604 RESEARCH METHODS FOR THE CLINICAL SCIENCES (3)

CSC 605 EPIDEMIOLOGY AND BIOSTATISTICS (3)

CSC 606 ADVANCED LABORATORY STATISTICS AND ADMINISTRATIVE ANALYSIS (3)

CSC 615 REPRODUCTIVE LABORATORY SCIENCE (1)

CSC 616 ANDROLOGY (1)

CSC 617 REPRODUCTIVE MICROBIOLOGY AND IMMUNOLOGY (1)

CSC 618 LABORATORIES IN ANDROLOGY, REPRODUCTIVE MICROBIOLOGY, AND IMMUNOLOGY (1)

CSC 621 EMBRYOLOGY/ASSISTED REPRODUCTIVE TECHNOLOGY (3)

CSC 624 GAMETE AND EMBRYO CRYOPRESERVATION (1)

CSC 625 POLICY, MANAGEMENT, ETHICAL AND LEGAL ISSUES IN ASSISTED REPRODUCTION (2)

CSC 626 ANDROLOGY CLINICAL PRACTICUM (1-2)

CSC 627 ART CLINICAL PRACTICUM (1-3)

CSC 628 RLS SEMINAR (1)

CSC 630 RLS RESEARCH (3-5)

CSC 670 HISTOCOMPATIBILITY AND IMMUNOGENETICS (3)

CSC 671 MOLECULAR IMMUNOPATHOGENESIS (3)

CSC 672 TRANSPLANTATION SCIENCE (3)

CSC 673 FLOW CYTOMETRY (3)

CSC 674 HEMOPOIESIS (3)

CSC 675 MYELOPROLIFERATIVE DISORDERS (3)

CSC 676 ADVANCED HEMOSTASIS (3)

CSC 690 CLINICAL SCIENCES THESIS RESEARCH (1-6)

CSC 749 CLINICAL SCIENCES DISSERTATION RESEARCH (0)

CSC 772 GENE THERAPY (3)

CSC 774 BIOSYNTHESIS, STRUCTURE AND FUNCTION OF MACROMOLECULES (3)

CSC 776 MOLECULAR GENETICS AND CHROMOSOME ANALYSIS OF HEMATOPOIETIC DISORDERS (3)

CSC 777 HEMATOPOIETIC STEM CELL AND BONE MARROW TRANSPLANTION: NONTRADITIONAL APPLICATIONS (3)

CSC 778 CLINICAL MOLECULAR CYTOMETRY (3)

CSC 787 TEACHING APPRENTICESHIP (2)

CSC 789 RESEARCH APPRENTICESHIP (1-4)

CSC 790 CLINICAL SCIENCES DISSERTATION RESEARCH (0-12)

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