Graduate School Bulletin - Spring 2006
Admission Requirements

For admission to graduate study in pharmaceutical sciences a student should have a sound background in biology, chemical engineering, chemistry, or pharmacy, with a mastery of mathematics through calculus.

Entry into the program will require an undergraduate or professional program GPA of at least 3.2 for the Ph.D. degree. We also require three letters of recommendation from current or former college professors addressing the scientific research skills and motivation of the applicant.

The Pharmaceutical Sciences Graduate Program was established in 1967 to prepare motivated individuals for academic and industrial careers in pharmaceutical and biomedical research. It has trained more than 220 Ph.D. graduates. The program offers two training options: a traditional option in which most of the students have been enrolled, and another track focused on clinical research.

Traditional Pharmaceutical Science Track

The goal is to develop scientists who possess a blend of contemporary basic science skills and an understanding of their role in the development of new drugs. This is achieved through intense laboratory experiences in a biomedical science of interest, such as pharmacology, medicinal chemistry or pharmaceutics that lead to a laboratory-based dissertation research project.

Clinical Pharmaceutical Science Track

The goal is to develop scientists who possess a blend of contemporary clinical and basic science skills. This is achieved through research in the clinically oriented pharmaceutical sciences that includes intense clinical experience in a medical specialty of interest, such as cardiology, neuroscience, critical care, neonatal/pediatric medicine or oncology and an integrated laboratory-based and clinical dissertation research project. A Pharm.D., M.D., D.D.S., D.V.M. or other professional health degree is required for admission into this training track.

Both Tracks include state-of-the-art course work.

Research projects are focused in one of four areas of Graduate Study.

Drug Discovery and Design

Research in this area focuses on chemical, biochemical, biophysical and molecular approaches toward the design and development of new therapeutic entities. Specific areas of focus include the development of anticancer agents, anti-inflammatory drugs, anti-thrombotic drugs, novel opiate analgesics, anticonvulsants, anti-Alzheimer and anti-Parkinson drugs, agents for the treatment of psychostimulant abuse, neuroprotective agents, and drugs that interact with nicotinic receptors. Research is also being carried out on cell signaling pathways, facilitating the development of strategies designed to correct such signaling defects.

Pharmaceutics Drug Delivery and Analysis

Research in this area focuses on discovery and evaluation of novel drug delivery systems as they relate to the physical, chemical, and biochemical properties of a therapeutic entity. It includes the development of intravenous and extravascular dosage formulations for synthetic organic molecules, bioengineered proteins, and anti-sense oligonucleotides to optimize their therapeutic value.

Pharmacology

Research in this area utilizes multidisciplinary approaches to study drug response mechanisms in healthy and pathophysiological states. It includes substrate/receptor interactions, and their ability to trigger physiological, pharmacological and toxicological responses in various models ranging from cell culture, to whole animal studies.

Pharmacodynamics, Pharmacokinetics and Drug Metabolism

Research in this area focuses on characterization and assessment of the relationship between drug concentration and response. It is supported by studies on the fundamental mechanisms by which drugs and other bioactive substances are absorbed, transported, metabolized, and excreted from the body. It utilizes state-of-the-art techniques to understand the cellular and molecular basis for the effect that disease, genetic variation and drug-drug interactions may have on these processes.

Course Work

The following courses will be taken by all students enrolled in the program, although courses may be waived or other courses substituted given the background of the individual student.

PHR 760 Introduction to Pharmaceutical Sciences 2

PHA 522 Systems Pharmacology 3

IBS 601 Biomolecules and Metabolism 3

IBS 602 Biomolecules and Molecular Biology 3

STA 570 Basic Statistical Analysis 4

Departmental Seminar Series

and

Graduate Student Seminar Series total 2 each year

Additionally, students take some of the following courses, depending on their Area of Graduate Study:

CHE 440G Physical Chemistry 3

CHE 538 Advanced Organic Chemistry 3

PGY 502 Physiology 5

BCH 608 General Biochemistry II 3

PHR 612 Quantitative Pharmacodynamics: Pharmacokinetics 3

PHR 647 Introduction to Molecular Pharmacotherapeutics 3

PHR 649 Advanced Molecular Pharmacology 2

PHR 664 Theory and Practice of Drug Metabolism 3

PHR 776 Seminar in Pharmaceutical Sciences I 1

PHR 778 Seminar in Pharmaceutical Sciences II 1

Students often take electives that prepare them for their dissertation research project and career goals. Some of these electives are:

PHR 510 Modern Methods in Pharmaceutical Analysis 5

PHR 520 Special Topics in Pharmacy Law 2

PHR 525 Introduction to Sociopharmacology 2

PHR 530 Radiopharmaceutics 3

PHR 541 Pharmaceutical Technology Clerkship 4

PHR 545 Sterile Parenterals and Devices 2-3

PHR 595 Independent Problems in Pharmacy
Administration 1-3

PHR 620 Natural Products Chemistry 3

PHR 622 Advanced Biopharmaceutics 2

PHR 630 Pharmaceutical Rate Processes 3

PHR 631 Equilibrium Phenomena in Pharmaceutical Systems 3

PHR 645 Neurotoxicology 2

PHR 762 Bioorganic Mechanisms 3

PHR 779 Membrane Science Colloquium 1

For further information visit our Web site: <www.uky.edu/Pharmacy>, then select Graduate Program.

GRADUATE COURSES

PHR 510 MODERN METHODS IN PHARMACEUTICAL ANALYSIS (5)

PHR 530 RADIOPHARMACEUTICS (3)

PHR 545 STERILE PARENTERALS AND DEVICES (2-3)

PHR 612 QUANTITATIVE PHARMACODYNAMICS: PHARMACOKINETICS (SAME AS PHA 612) (3)

PHR 620 NATURAL PRODUCTS CHEMISTRY (3)

PHR 622 ADVANCED BIOPHARMACEUTICS (2)

PHR 630 PHARMACEUTICAL RATE PROCESSES (3)

PHR 631 EQUILIBRIUM PHENOMENA IN PHARMACEUTICAL SYSTEMS (3)

PHR 645 NEUROTOXICOLOGY (2)

PHR 647 INTRODUCTION TO MOLECULAR PHARMACOTHERAPEUTICS (3)

PHR 649 ADVANCED MOLECULAR PHARMACOLOGY (SAME AS PHA/TOX 649) (2)

PHR 664 THEORY AND PRACTICE OF DRUG METABOLISM (3)

PHR 668 PSYCHOTHERAPEUTICS FOR ADVANCED NURSING PRACTICE (SAME AS NUR 668) (3)

PHR 748 MASTER'S THESIS RESEARCH (0)

PHR 749 DISSERTATION RESEARCH (0)

PHR 760 TOPICS IN PHARMACEUTICAL SCIENCES (1-4)

PHR 762 BIOORGANIC MECHANISMS (3)

PHR 768 RESIDENCE CREDIT FOR THE MASTER'S DEGREE (1-6)

PHR 769 RESIDENCE CREDIT FOR THE DOCTOR'S DEGREE (0-12)

PHR 774 GRADUATE SEMINAR IN PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (1)

PHR 776 SEMINAR IN PHARMACEUTICAL SCIENCES I (1)

PHR 778 SEMINAR IN PHARMACEUTICAL SCIENCES II (1)

PHR 779 MEMBRANE SCIENCES COLLOQUIUM (SAME AS CHE/CME/BCH/PHA 779) (1)

PHR 780 SPECIAL PROBLEMS IN PHARMACEUTICAL SCIENCES (1-6)

PHR 790 RESEARCH IN PHARMACEUTICAL SCIENCES (1-12)

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