News & Events

Larry Kranking named CEO of Coldstream Laboratories Inc.

LEXINGTON KY (August 23, 2010) — Larry Kranking has been named the new President and CEO of Coldstream Laboratories Inc. (CLI), the largest sterile pharmaceutical manufacturing facility in Kentucky.


Kranking, who comes to CLI from Aveta Lifesciences-usa in Valparaiso, Ind., has 38 years of experience as a pharmaceutical executive leading start-up companies and implementing innovative regulatory strategies. Kranking will head a staff of 70 who provide full service GMP sterile manufacturing services for international biotech and pharmaceutical clients who require small batches of product for use in pre-clinical trials to commercial distribution.


"Larry is an internationally recognized industry leader who has helped develop the guidelines that define today's biopharma manufacturing world," said Len Heller, chairman of the board of CLI. "Larry also brings expertise in the area of ANDA drug development which will be important to CLI as we move into our fourth year of operation," said Heller, who also serves as the University of Kentucky Vice President for Commercialization & Economic Development.


"CLI is in an excellent position to expand our customer base and services as we leverage the University of Kentucky's position as a premier research institution and global leader in cancer research and drug development," said Larry Kranking, whose business operations experience includes the startup of cGMP manufacturing facilities for Boehringer Ingelheim and Eisai Inc. "We want to position Coldstream Laboratories as the bridge between drug discovery and commercial business."


Kranking replaces Joe Wyse who transitioned CLI from the University of Kentucky Center for Pharmaceutical Science & Technology to a private business in 2007. "Joe has done a tremendous job the past three years navigating all of the issues and regulations inherent in a start-up business and a cGMP pharma operation while starting to build an international client base," said Heller.


Coldstream Laboratories Inc., located at the Coldstream Research Campus, is wholly owned by the University of Kentucky through the University of Kentucky Research Foundation.

Coldstream's barn owls fledge, nesting box installed

LEXINGTON, KY (July 28, 2010) — Coldstream's temporary tenants, a pair of federally protected barn owls and their chicks, have fledged and a permanent nesting box has been installed. Barn owls have what scientists call a high "nest fidelity," meaning they often return to the same nest each year.


Barnowl"The owls will come back and find their nest has been closed up and hopefully they will find our box to be suitable since it's so close (to the original nest)," said Kate Heyden, an avian biologist with the Kentucky Department of Fish and Wildlife Resources. The new nesting box was installed near the owl's original nest near the top of the Lexhold building and provides a plywood space 2.5 ft. wide and 1ft. high.


"I watched one of the chicks take its first flight," Heydon said. "It flew to the rooftop ... of the building, then took many small flights from there to build up its strength."


She said the owl family might still be seen around the building for the next month or so and the adults will stay in the area through the winter. The owls were first discovered in June by a construction worker who was completing final detailing on the building. Wildlife officials were called in and construction halted until the young birds flew away.


Biologists think the numbers of barn owls are decreasing because the owls like to nests in old trees with hollow spaces or in hay barns or other old buildings that are becoming increasingly scarce.

New body temperature alert patch allows athletes and others to "beat the heat"

Editor's note: ionX International Inc. is headquartered at UK's Coldstream Research Campus. Read more on ionX and the iDot patch in Business Lexington.


LEXINGTON, KY (June 25, 2010) — After being stuck in gyms and indoor workout facilities during the frigid winter months, cyclists and runners are filling parks and roadways, relishing the warmer weather. Baseball diamonds and golf courses are teeming with players, and spring training is in full swing on high school and college athletic fields across the country. And while the shift to the outdoors is always welcome after a long winter, the sun can quickly warm to the point of danger for those who play — and work — in the heat of day.


To serve as a first line of defense against overheating and possible hyperthermia, ionX International has recently launched its Body Temperature Alert Patch, an early warning device, designed to help prevent heat stroke and potentially save lives. As the wearer's core body temperature increases, the disposable, single-use ionX Alert Patch changes from black to bright yellow, warning the wearer if and when there is a danger of overheating. Once the individual has cooled to a non-risk temperature, the patch will return to the original color. (The patch will change color again when the body temperature increases to an elevated level.) By mid- to late-June, the ionX Alert Patch will be available at more than 550 retail outlets nationwide, including The Sports Authority and select Hibbett Sports.


Easy-to-use ionX Alert Patch signals a "first warning"
The patented nano-polymer technology of the Alert Patch responds to core body temperature changes, allowing it to indicate rise and fall of temperature. When the wearer's core temperature reaches elevated levels, the Alert Patch begins to change from black to yellow. At a risk point, the patch turns a noticeable yellow that is easily visible, even from a distance as far away as the sidelines. The patch does not react to external temperatures or humidity; and since the inks do not wear out, the patch will continue to change color and measure body temperature as long as it is worn.


With the same characteristics and application of a bandage, the Alert Patch is round, elastic and waterproof, staying securely in place during physical activity. Due to the nature of the adhesive, the patch is designed for a single use. To accurately measure core temperature, the Alert Patch is placed on an area with blood vessels or capillaries close to the surface of the skin on the neck artery; the bicep just before the inner elbow; the inner forearm just before inner elbow; or the wrist just before the hand.


Dog days of summer can have tragic consequences
Summer can bring heat waves with unusually high temperatures that last for days or even weeks. Nearly 700 people in the U.S. die each year from exposure to heat (with thousands more treated in emergency situations), and heat stroke is the third-leading cause of death for high school athletes. Naturally, hotter weather can be even more devastating: The United States experienced an intense heat wave in the summer of 1980, resulting in nearly 1,700 deaths from heat-related illness. And in the summer of 2003, tens of thousands of Europeans died during a similar heat wave. But heat-related illnesses and fatalities are completely preventable if a person knows he or she is close to overheating and takes steps to reduce their heat exposure.


Human beings suffer heat-related illness when the body's temperature control system is overloaded. The body normally cools itself by sweating. In certain conditions, such as high humidity, sweating doesn't cool the body effectively and body temperature rises rapidly, which can damage the brain or other vital organs. Other factors that can limit the body's ability to regulate temperature include old age, obesity, fever, dehydration, heart disease, poor circulation, sunburn and drug or alcohol use.


About ionX International, Inc.
Lexington, Kentucky-based ionX International, Inc. is wholly owned by Ionx Capital Holdings, Inc. (ICH), a diversified, private-equity company engaged in product development. The Body Temperature Alert Patch is one of many new technologies created for improved health and wellness by ICH.

Allylix featured in The Economist

LEXINGTON, KY (June 24, 2010) — Allylix is featured in this week's edition of The Economist in a special section titled "A special report on the human genome: Inhuman genomes." Allylix, a biotechnology firm, licensed its original technology from UK's College of Agriculture and today uses it for the low cost production of high-value terpene products through yeast fermentation. UK is part of the original investors in Allylix through Kentucky Technology Inc. and the Bluegrass Angel Fund. Individual Bluegrass Angels are also original 2004 investors and joined national investors in 2007 for a $3.35 million B round of funding. Allylix has business offices in San Diego, Ca. and research and development laboratories at UK's Coldstream Research Campus. See for additional information.

Protected Barn Owls nest at Coldstream

barnowlLEXINGTON, KY (June 4, 2010) — UK's Coldstream Research Campus has new, though temporary, tenants. Protected under the federal Migratory Bird Treaty Act, a pair of nesting barn owls is raising four barn owl chicks in a nest at the top of the Lexhold building off Aristides Boulevard.


The owls were first discovered by a construction worker who was completing the building's "eyebrow," an architectural feature that runs across the top of the building. Wanting to be good environmental stewards, Bill Bishop, who is overseeing the completion of the building, and construction manager Bill Borregard contacted the state fish and wildlife experts to identify the birds.


The preservation of barn owls is a major concern in much of the U.S. including Kentucky. The birds traditionally nest in hollowed out tree cavities. As these become increasingly scarce, however, the owls have moved to barns and other structures adjoining vast pastoral spaces.


According to Kate Heyden, an avian biologist with the Kentucky Department of Fish and Wildlife Resources, there are currently only 10 known nests in Kentucky. Construction on the Lexhold building will be delayed until the end of June when it is expected that all of the barn owl chicks will leave the nest. An agreement has also been made to install an owl box on top of the eyebrow as barn owls often return to the same spot to nest again.

FEMA leases space at Coldstream Research Campus

LEXINGTON, KY (June 2, 2010) — The Federal Emergency Management Administration (FEMA) has leased space at the University of Kentucky's Coldstream Research Campus following Kentucky's designation as a major disaster area May 11. Approximately 61,000 square feet in the Lexhold Technology Building off Aristides Boulevard will serve as a central coordinating location for the 300 FEMA professionals who have been mobilized for federal recovery operations in affected Kentucky counties.


According to Len Heller, UK's vice president for Commercialization and Economic Development, FEMA selected Coldstream because of its location at the intersection of I-75 and I-64.


The FEMA Web site is reporting that people in 61 Kentucky counties are eligible for individual assistance (assistance to individuals and households) following the May 1 severe storms, flooding, mudslides, and tornadoes.


FEMA and the Kentucky Division of Emergency Management are operating disaster recovery centers around Kentucky. Please note that the facility at Coldstream is not a disaster recovery center. Additional information is available at and or by calling toll-free 800-621-FEMA (3362) (for TTY call 800-462-7585).

USEF Drug Testing and Research Lab will relocate to Coldstream Research Campus

LEXINGTON, KY (April 5, 2010) — The drug testing and research lab for the United States Equestrian Federation will relocate from Ithaca, N.Y. to UK's Coldstream Research Campus by the end of the year. According to UK Vice President for Commercialization & Economic Development Len Heller, "USEF will move their research and testing operations into a re-fitted, 7,500 sq. ft. lab space in the Kentucky Technology Center complex at Coldstream called the mini campus."


The USEF is headquartered at the Kentucky Horse Park and drug tests and licenses equestrian competitions of all levels across the country, in addition to training, selecting and funding the U.S. Equestrian Team. "The decision to bring the lab to Lexington has to do with many things including being headquartered here, but it also has to do with being part of the legacy of the World Equestrian Games this fall," says USEF CEO John Long.


The 2010 Alltech FEI World Equestrian Games will be held at the Kentucky Horse Park September 25 to October 10. The new USEF testing lab at Coldstream Research Campus is anticipated to bring 12 jobs paying an average $26 an hour including benefits.

Governor Beshear announces expansion of Lexington pharmaceutical company

FRANKFORT, Ky. (December 14, 2009) Gov. Steve Beshear and Cabinet for Economic Development representatives today joined community and company officials to announce Lexington-based Summit Biosciences, a specialty pharmaceuticals business and client of the Lexington Innovation and Commercialization Center, will expand its operation creating 22 new jobs and investing over $5 million in the Commonwealth. Seventeen of the projected new jobs are high-tech positions with an average annual salary of more than $64,000.


Summit develops and manufactures generic prescription and new over-the-counter (OTC) pharmaceutical products administered to patients by means of a nasal spray. The company plans to submit the first of several applications to the U.S. Food & Drug Administration (FDA) in mid-2010 in order to receive approval to manufacture and market its generic products starting in 2011 and 2012.


“The creation and retention of jobs for Kentuckians continues to be a top priority of my administration,” said Gov. Beshear. “During these difficult economic times, I am especially pleased to announce that 22 new quality jobs will now be available in Lexington. The drugs under development by Summit Biosciences take advantage of an increasingly popular medication delivery method, which can help boost the company’s sales and lead to the creation of many new high-tech jobs in Kentucky.”


The company is also developing new OTC nasal spray products for which it will apply for patents and plans to begin manufacturing in the first quarter of 2010. Several patent applications are expected to be filed in 2010 relating to the company’s OTC products.


To date, Summit has secured a partnership with a publicly traded generic-drug manufacturing company to jointly develop generic versions of five FDA-approved nasal spray products, including one to treat osteoporosis and others used to treat migraine headaches. The company has also secured a contract manufacturing agreement with a company to develop and make a new nasal spray product to treat pain.


“We are pleased with the excellent progress we have made thus far toward commercializing our products, reducing healthcare costs and creating jobs,” said Greg Plucinski, chief operating officer at Summit Biosciences. “We secured our first partnership agreement in June, completed the acquisition of our fully equipped manufacturing facility in August and are currently focused on developing our pipeline products.”


The Kentucky Economic Development Finance Authority (KEDFA) preliminarily approved Summit Biosciences for funding up to $250,000 in the form of a forgivable loan from the Cabinet for Economic Development’s High-Tech Pools, which are used to build technology-based and research-intensive companies and projects. KEDFA also preliminarily approved Summit Biosciences for tax incentives up to $500,000 under the Kentucky Business Investment (KBI) program. KBI incentives can be earned through corporate income tax credits and wage assessments.


“The support from the state and city will contribute immensely toward our greater goals as we bring lower-cost generic and innovative nasal spray products to market,” added Plucinski. “We look forward to receiving additional support and are proud to contribute to job creation and reducing the cost of healthcare through the growth of Summit Biosciences.”


“Today’s announcement illustrates the potential of our healthcare and our high-tech sectors and the enormous benefit of being the hometown of the University of Kentucky and its outstanding College of Pharmacy,” said Lexington Mayor Jim Newberry. “The nationally ranked College has long been a leader in the development of nasal delivery systems, and Summit Biosciences has funded portions of this research. The good jobs that will be created by Summit also illustrates the strength of an economic development process that involves government, the University and the private sector.”


“Summit Biosciences is the type of company that will make a great impact on the Bluegrass region,” said Commerce Lexington President & CEO Bob Quick. “Summit is working diligently on developing products that will reduce healthcare costs, as well as creating high-tech jobs for our citizens. The Bluegrass Business Development Partnership has worked closely with Summit, and we are excited to welcome them to Lexington.”


For more information on Summit Biosciences, visit A community profile for Lexington can be viewed at:


The Kentucky Cabinet for Economic Development is the primary state agency in Kentucky responsible for creating new jobs and new investment in the state. New business investment in Kentucky in 2008 totaled nearly $1.7 billion with the creation of more than 7,750 new jobs. Information on available development sites, workforce training, incentive programs, community profiles, small business development and other resources is available at

Governor Beshear unveils plans, drawings of New Eastern State Hospital

LEXINGTON, KY (Oct. 30, 2009) − Governor Steve Beshear has unveiled plans and artist renderings of a new Eastern State Hospital facility, to be built on a site at the University of Kentucky's (UK) Coldstream Research Campus in Lexington. Construction on the project is scheduled to begin in July 2010.


The 230-bed, approximately 300,000 square foot replacement facility will provide a modern setting for inpatient psychiatric treatment, along with specialized services for individuals with acquired brain injuries, individuals with psychiatric disabilities requiring nursing facility level of care and forensic mental health services.


In addition to the inpatient hospital, the new Eastern State Hospital campus will include three 11,000 square foot personal care homes, each with 16 beds that will offer a less restrictive level of care that promotes patients' return to a community setting. These personal care homes will provide residential psychiatric services and serve as a step-down from the acute care setting.


"Unveiling the plans and drawings for this new facility puts us yet another step closer to the day in which we open the doors of the new Eastern State Hospital, transforming how Kentucky cares for individuals with mental health needs," said Gov. Beshear.


The $129 million facility will replace the 185-year-old Eastern State Hospital, the second oldest psychiatric hospital in the country. The project involves a unique agreement between UK, Bluegrass Community and Technical College (BCTC), the state and the city of Lexington in which Eastern State will move from its campus on Newtown Pike to the Coldstream Research Campus location; BCTC will move from UK’s Lexington campus to the current Eastern State location; and UK will take over BCTC’s location on Cooper Drive, also providing UK with additional parking.


"This new hospital, and the move of Bluegrass Community and Technical College to the former Eastern State site, represents a huge leap ahead for Lexington and for the Commonwealth," Lexington Mayor Jim Newberry said. "The new hospital underscores Lexington's lead role in providing advanced health care throughout Kentucky and across the nation. Construction projects are ongoing or planned in the near future at every major hospital in town. Lexington is also a national leader in education, and this new campus will complete our higher education triangle downtown, giving BCTC the room it needs to grow so that it can provide our region and the country with the highly trained work force necessary to compete in a global economy."


"This is an exciting moment for the Commonwealth," said UK President Lee T. Todd Jr. "Not only will this collaborative effort provide Eastern State Hospital with a modern, world-class facility that it needs, but it will also provide an exciting new tenant to UK's ever-growing Coldstream Research Campus."


The design will be finalized over the next several months, with the bidding process for the construction tentatively scheduled for approximately June 2010. Substantial completion of the facility is anticipated in 2012. The facility will be Leadership in Energy and Environmental Design (LEED) Certified, meaning it will meet the highest green building and performance measures.


"We are particularly excited about the expansion of services the new facility will allow," said Cabinet for Health and Family Services Secretary Janie Miller. "For example, the addition of neuro-behavioral beds and geriatric-nursing facility beds will create the opportunity for individuals with acquired brain injuries and elderly patients with severe mental illness to receive needed inpatient psychiatric treatment closer to their family and natural support setting."


Eastern State Hospital serves an average of 2,000 patients per year from 80 Kentucky counties. The primary counties served include Boyle, Madison, Franklin, Kenton and Fayette, ranging from 65 to 279 patients annually.

Lexington ranks 6th for best mid-sized metro to launch a small business

Editors note: Lexington has ranked sixth for best mid-sized metro area to launch a small business according to's 2009 report. The annual report ranks large, mid and small metro areas based on economic growth, affordable workers and few forclosures. All statistics are for the full Metropolitan Statistical Area. For a complete list of data sources, see's "How we picked the Best Places."


By Maya Payne Smart,, Best Places to Launch: The best metro areas for small business startups


LEXINGTON, KY (Oct. 14, 2009) − Lexington puts a unique spin on 4-H: Horses, health care, high-tech and higher education make up its diversified economy.


Known as the Thoroughbred Capital of the World, Lexington is home to horse farms that handle more than $750 million in horse sales annually. The region is expected to reap another $150 million in economic activity when hundreds of thousands of visitors come to town for the 2010 World Equestrian Games in September 2010. The city's revitalization efforts have reached warp speed in preparation for the event: New music venues and restaurants are sprouting, along with fresh parks and biking and walking trails.


Even in the absence of major events, Lexington knows how to draw a crowd. Residents throughout the eastern third of Kentucky travel miles to reach its retail stores and three major hospitals, all of which have begun major expansion projects.


The University of Kentucky, Transylvania University and another dozen colleges, universities and technical colleges educate workers for Lexington's growing tech sector, which includes strong Lexmark, IBM and Hewlett-Packard presences.


Local businesspeople say the municipal government is undergoing a vast restructuring to eliminate redundancies and improve communication, which promises an even more welcoming environment for business owners.


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