Online Graduate Advanced Pathophysiology Course


(for college credit given by your university)

Pre-Requisite: Must be a current graduate student enrolled at an institution

Interested in taking the course? Follow these steps to begin:

  1. Have your faculty member or advisor complete the faculty approval form and return to Aimee Hatfield at : Download faculty approval form here
  2. Once you have submitted the faculty approval form, register online at 
  3. After our office has received your registration, you will be emailed instructions to access and begin the online course

Click here to download course syllabus


This class uses technology to enhance active construction of knowledge. It is an online course that will be available to students through the college/university where they are enrolled.The class time will be asynchronous with students using two specific pathophysiologic websites, pathophysiologic videos and assignments per module.

Course Description 
This course is designed to present an orientation to disease as disordered physiology. It is intended to enable advanced practice nurses to understand how and why the symptoms and signs of various conditions appear. In approaching disease as disordered physiology, this course analyzes the mechanism(s) of production of the symptoms and signs of different disease syndromes. In doing so, it recognizes the student’s and practitioner’s need to understand the mechanism(s) underlying the disease and its clinical manifestations so that rational therapies can be devised. Thus, appropriate screening and diagnostic laboratory evaluative methods will also be included.

Course Objectives
The advanced practice nurse should possess a well-grounded understanding of normal physiologic and pathologic mechanisms of disease that serves as one primary component of the foundation for clinical assessment, decision making and management. The graduate should be able to relate this knowledge to “interpreting changes in normal function that result in symptoms indicative of illness” and in assessing an individual’s response to pharmacologic management of illness. At the completion of this course, students will have the knowledge and skills to:

  • compare and contrast physiologic changes over the life span;
  • analyze the relationship between normal physiologic and pathological phenomena produced by altered states across the life span;
  • synthesize and apply current research-based knowledge regarding pathological changes in selected disease states;
  • describe the developmental physiology, normal etiology, pathogenesis, and clinical manifestations of commonly found/seen altered health states;
  • analyze physiologic responses to illness and treatment modalities;
  • analyze data with respect to diagnosing client problems.


Teaching/Learning Methods 
This course will be taught using a combination of 10 modules and specific World-Wide Web sites. The assumption is made that all students have access to computer facilities, the Internet, a web browser (current Firefox or IE) or higher, Adobe Acrobat and Adobe Flash Player installed, a color printer, and an E-mail address. Since active learning is required, students are expected to complete all assignments in a timely manner. However, this is student directed and no time limits are set within the technology.



After completing the Pre-Approval form

  • Adv. Pathophysiology for college credit (Modules 1-10) - $500


The Internet and Websites: The Internet has been portrayed with a variety of images. Allusions are made to road systems (“the electronic superhighway”), Star Treck adventurers (“internauts in space”), and to a world community (the “electronic global village”). An exciting way to learn about pathophysiology is by using the Internet and different WEB SITES. For any of the different body systems or sites, the Internet offers a broad array of academic and academic related resources:

 · professional and governmental archives and databases

· on-line journals

· access to commercial databases and abstract services

· professional discussion via news groups, mailing lists, and discussion groups

· academic and public library catalogs

· grant listings and deadlines

· directories of researchers and research projects funded by federal government

· conference announcements and calls for papers

· academic, government and industry job announcements

· faculty biographies and university


The module activities (assignments) will come from two major Web-Sites:

1. The Internet Patholophysiology Laboratory for Medical Education This web-based resource includes over 1900 images along with text, tutorials, laboratory exercises, and examination items for self-assessment that demonstrates pathophysiologic concepts

2. This web-based resource lists pathophysiological conditions alphabetically, related terms, a main article, related medical procedures/tests, related news and updates, and related diseases and treatments.

For ease, please bookmark these two sites


There is one posttest for each module which consists of questions from the modules and the two web sites. Each posttest is designed to test your understanding of the material in the module. By completing all of the modules and the final exam with an 80% or more, you will get 3 hours of credit certified by the University of Kentucky. You can only take each posttest twice. The modules are worth 80% of the course grade and the final exam 20%

There are 600 points in the course. The final letter grade will be computed from a percentage of correct questions. The percentage grade will be sent to your school and your letter grade will be computed based on the policy of your school. 

For example: 
600 points = 100 percent 
540 points = 90 percent 
480 points = 80 percent


Web-Based Learning 
To take this course, each student must:

  • have Internet access;
  • register for the course;
  • follow instructions;
  • set up an account;
  • receive an enrollment key for the course.



Pathophysiology: The Biological Basis for Disease in in Adults and Children McCance & Huether. 7th edition Mosby/Elsevier.ISBN: 978-0-323088541 2014. This is the book I recommend, however, any other advanced pathophysiology book will be acceptable.

Module Topics and Assignments



Major Topic

Module 1

Introduction to General Pathology: Mechanisms of Disease

Pathophysiological conditions from Web sites 1 and 2, Post-test 1

Module 2

Hematologic Disorders

Pathophysiological conditions from Web sites 1 and 2, Post-test 2

Module 3

Cardiovascular Physiology

Pathophysiological conditions from Web sites 1 and 2, Post-test 3

Module 4

Renal Pathophysiology

​ Pathophysiological conditions from Web sites 1 and 2, Post-test 4

Module 5

Respiratory Pathophysiology

​ Pathophysiological conditions from Web sites 1 and 2, Post-test 5

Module 6

Endocrine and Metabolic Disorders

Pathophysiological conditions from Web sites 1 and 2, Post-test 6

Module 7

Disorders of the Reproductive Systems

Pathophysiological conditions from Web sites 1 and 2, Post-test 7

Module 8

Fluid and Electrolyte Disorders

Pathophysiological conditions from Web sites 1 and 2, Post-test 8

Module 9

Gastrointestinal Pathophysiology

​ Pathophysiological conditions from Web sites 1 and 2, Post-test 9

Module 10

Neurological Disorders

Pathophysiological conditions from Web sites 1 and 2, Post-test10 

  Final Examination Syllabus for Web-based pathophysiology course


Contact: Aimee Hatfield at or (859) 323-3851.