-
- Statistical Methodology in Alzheimer's Disease
Research
-
- Scientific Program Schedule
-
- Richard Kryscio & Frederick Schmitt, University of Kentucky:
Conference Co-Chairs
-
Friday, May 15 -- Radisson Hotel, Lexington, KY
Noon - 1:00 p.m.: Registration
1:00 - 1:15p.m.: Opening Remarks
William R. Markesbery, Director, University of Kentucky, ADRC
Creighton Phelps, National Institute on Aging
1:15 - 3:00p.m.: Invited papers Session I: Measurement Issues (Gerald vanBelle,
Chair)
Measurement of progression in Alzheimer's disease: a clinician's perspective
-- Douglas Gelb, University of Michigan:
Cognitive, behavioral, and functional change in Alzheimer;s patients followed over time
-- Richard C. Mohs, Mount Sinai School of Medicine
Reliability of neuropsychological tests with bounded range
-- Gerald vanBelle and Alice Arnold, University of Washington, Seattle
3:00 - 3:15 p.m.: Break
3:15 - 5:15 p.m.: Poster Session I:
Application of item response theory models to cognitive measures
-- Jeanne A. Teresi, et al., Cloumbia University
Development of measurements of cognitive function for cross-cultural studies
-- Kathleen S. Hall, et al., Indiana University
Modeling decline in cognitive test scores using different cognitive measures and
statistical models
-- Xinhua Liu, et al., Columbia University
Balanced distributed database design in a clinical and research environment
-- Eszter Gombosi, et al., University of Michigan
Data Management in a cross-culutural study
-- R. John Roberts, et al., Indiana University
Alzheimer's Disease; Change over time in MMSE, SPECT.
-- J. Wesson Ashford, et al., University of Kentucky
Evaluating the stability of the clinical dementia rating in a multi-center clinical
trial
-- Kimberly Schafer, et al, University of California, San Diego
Fitting the trilinear model for decline in Alzheimer's disease
-- James Schmeidler, et al., Mount Sinai School of Medicine
Saturday, May 16
7:45 - 8:30 a.m.: Continental Breakfast (provided)
8:30 - 10:15 a.m.: Invited Session II: Longitudinal Methodology. (Ron
Thomas, Chair)
Longitudinal assessment of an Alzheimer cohort using the Mini-Mental State Examination
and Matti Dementia Rating Scale
-- Douglas Galsako, et al., University of California, San Diego
Statistical analysis of repeated-measures data with drop-outs
-- Roderick J. Little, University of Michigan
Statistical methodology for assessing cognitive decline in Alzheimer's disease from
longitudinal data
-- Ronald J. Thomas, University of California, San Diego
10:30 - noon: Contributed papers: parallel sessions
Session A: (David Wekstein, Chair)
Longitudinal measures of cerebral volume in patients with Alzheimer's disease
-- Charles DeCarli, University of Kansas
Application of item response theory to developing a global functioning measure with
linear measurement properties
-- Dan Mungas & Bruce R. Reed, University of California, Davis
Assessing relative accuracies of screening tests in the same two-stage epidemiological
study for Alzheimer's disease
-- Xiao-Hua Zhou, Indiana University
Antioxidants and memory in the elderly
-- Anthony J. Perkins, et al., Indiana University
Estimating odds ratios adjusting for misclassification in Alzheimer's disease risk
factor assessment
-- Christine L. Emsley, et al., Indiana University
Characterizing types of heterogeneity in AD: states vs. traits
-- Joy L. Taylor, et al., Stanford University
Session B: (Frederick Schmitt, Chair)
A change point model for estimating the onset of cognitive decline in preclinical
Alzheimer's disease
-- Charles B. Hall, University of Connecticut; Richard B. Lipton and Martin Sliwinski,
Albert Einstein College of Medicine; Walter F. Stewart, Johns Hopkins University
Time Intervals between evaluations in incidence studies of dementia - effects of
mortality and loss to follow-up.
-- Siu L. Hui, et al., Indiana University
Estimating the incidence of Alzheimer's disease from longitudinal two-phasee sampling
-- Sujuan Gao, et al., Indiana University
The impact of special care units on the quality of life of demented elderly: modeling
the covariance structure in a multicenter national collaborative study
-- Eva Petkova & Jeanne Teresi, columbia University
Assessing clinically meaningful cognitive change in the individual Alzheimer's disease
patient
-- Stephen M. Sawrie, et al., University of Alabama at Birmingham
Factor structure and reliability of Alzheimer's disease assessment scale in
multi-center trial of tacrine
-- S. Talwalker & S.J. Gracon, Searle R&D, Monsanto, and Parke-Davis
Pharmaceutical
Noon - 1:30 p.m.: Conference Sponsored Lunch (provided)
1:30 - 3:15 p.m.: Invited Panel Session: Promoting interactions with basic
scientists and clinicians (J. Philip Miller, Chair)
Steven D. Edland, University of Washington, Seattle
J. Philip Miller, washington University, St. Louis
Frederick Schmitt, University of Kentucky
Diane Cronin-Stubbs, Rush Institute on Aging
3:15 - 3:30 p.m.: Break
3:30 - 5:00 p.m.: Poster Session II
On permissibility of covariogram models with applications to analyzing human brain
functional data
-- Ivo D. Dinov, et al., Florida State University and University of California, Los
Angeles
Sensitivity and specificity of a screening instrument for dementia used in the
Honolulu-Asia Aging Study
-- Grant Izmirlian, et al., National Institute on Aging and the Honolulu-Asia Aging Study
Modeling mental status changes using the CERAD data.
-- Marta mendiondo, et al., University of Kentucky
Random effects models of longitudinal Alzheimer's disease data: a cautionary note
-- J. Kevin Milliken & Steven D. Edland, University of Washington
Combinative rank based tests for comparing incidence rates and time of death in
Alzheimer's disease patients
-- Robin Mukherjee & Myron N. Chang, University of Florida
Does an interaction between smoking and drinking influence the risk of Alzheimer's
disease? Results from three Canadian data sets.
-- Suzanne L. tyas, University of Manitoba, John J. Koval, University of Western Ontario,
and Linda L. Pederson, Morehouse School of Medicine
Sunday, May 17
8:30 - 9:00 a.m.: Continental Breakfast (provided)
9:00 - 10:30 a.m.: Invited Papers Session III: Community Surveys. (Dwight
Brock, Chair)
Community-based studies of Alzheimer's disease: statistical challenges in design and
analysis
-- Laurel A. Beckett, Rush Alzheimer's Disease Center, Rush Institute for Healthy Aging
Projecting the incidence and prevalence of Alzheimer's disease
-- Ron Brookmeyer, Johns Hopkins University
Practical and conceptual issues related to the accurate estimate of incidence: the
Honolulu-Asia Aging Study
-- Lon White, et al., University of Hawaii and National Institute on Aging
10:30 - 10:45 a.m.: Break
10:45 - 11: 45 a.m.: Invited Session III (continued)
Lifetime risk of dementia and Alzheimer's disease
-- Ralph D'Agnostino, et al., Boston university
Dementia mortality in the U.S.: results of the 1986 national mortality followback
survey
-- Douglas J. Lanska, University of Kentucky
11:45 - noon: Closing Remarks: Richard J. Kryscio, University of
Kentucky