Olivier Thibault Ph.D.Pyramidal neuron calcium imaging

Concomitant glucose and calcium imaging during synaptic activation in the slice

 

 

 

 

 

 

 

 

 

 

 

 


Welcome to the Thibault research group at the University of Kentucky

Current lab interests include identifying the underlying mechanisms through which individual components of peripheral metabolic dysregulation (particularly hyperinsulinemia and hypercholesterolemia) impact brain function.

We focus on behavioral, electrophysiological, molecular, as well as calcium and glucose imaging techniques to identify alterations in neuronal function during aging and in Alzheimer's disease animal models.

We have modified the beta subunit of the insulin receptor and are currently delivering it to neurons and soon to animal models of aging.

We are on our third intranasal insulin study to offset cognitive decline with brain aging and the results are looking excellent!