The third exam will cover Chapters 1–8 in Klein. The following guidelines are not meant to be complete or comprehensive lists of the information you are expected to know.
You are expected to have command of all the material covered on the first and second exams.
You should be able to determine whether a given reaction is a substitution or an elimination.
You should be able to determine whether the reaction conditions for a substitution or elimination reaction are basic or acidic.
You should understand, and be able to explain, which of the SN1, SN2, E1, and E2 mechanisms can occur under basic or acidic conditions.
You should understand, and be able to explain, what factors affect the nucleophilicity and basicity of a lone-pair-bearing atom in a compound.
You should understand, and be able to explain, how the structure of an electrophile affects the rates of its reactions by the SN1, SN2, E1, and E2 mechanisms.
Given starting materials for a reaction, you should be able to predict and draw the major product of the reaction, indicating the correct C(sp3) or alkene stereochemistry, if appropriate.
Given starting materials and products of a substitution or elimination reaction, you should be able to draw a reasonable mechanism for the reaction in the format required by ACE.
Given a target compound, you should be able to use substitution or elimination reactions to design a synthesis of this compound from simpler starting materials, and you should be able to draw the synthesis in the format required by ACE.
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