Title | A Multidimensional Study of Vocal Function Following Radiation Therapy for Laryngeal Cancers. |
Publication Type | Journal Article |
Year of Publication | 2017 |
Authors | Angadi V, Dressler E, Stemple J |
Journal | Ann Otol Rhinol Laryngol |
Volume | 126 |
Issue | 6 |
Pagination | 483-492 |
Date Published | 2017 Jun |
ISSN | 1943-572X |
Keywords | Aged, Auditory Perception, Cohort Studies, Female, Humans, Laryngeal Neoplasms, Larynx, Male, Middle Aged, Pulmonary Ventilation, Radiotherapy, Self-Assessment, Speech Acoustics, Stroboscopy, Vocal Cords, Voice Quality |
Abstract | BACKGROUND: Radiation therapy (XRT) has proven to be an effective curative modality in the treatment of laryngeal cancers. However, XRT also has deleterious effects on vocal function. AIM: To demonstrate the multidimensional nature of deficits in vocal function as a result of radiation therapy for laryngeal cancer. STUDY DESIGN: Cohort study. METHODOLOGY: Vocal function parameters were chosen from the 5 domains of voice assessment to complete a multidimensional assessment battery. Adults irradiated (XRT group) for laryngeal cancers were compared to a control group of individuals with no history of head and neck cancers or radiation therapy. The control group was matched in age, sex, and pack years of smoking. RESULTS: Eighteen participants were recruited for the study. The XRT group demonstrated significantly worse clinical values as compared to the control group across select parameters in the each of the 5 domains of voice assessment. DISCUSSION: Radiation therapy for laryngeal cancers results in multidimensional deficits in vocal function. Notably, these deficits persist long term. In the present study sample, multidimensional deficits were persistent 2 to 7 years following completion of XRT. The observed multidimensional persistent vocal difficulties highlight the importance of vocal rehabilitation in the irradiated larynx cancer population. |
DOI | 10.1177/0003489417702922 |
Alternate Journal | Ann. Otol. Rhinol. Laryngol. |
PubMed ID | 28421833 |