Title | Starring or Supporting Role? Satellite Cells and Skeletal Muscle Fiber Size Regulation. |
Publication Type | Journal Article |
Year of Publication | 2018 |
Authors | Murach KA, Fry CS, Kirby TJ, Jackson JR, Lee JD, White SH, Dupont-Versteegden EE, McCarthy JJ, Peterson CA |
Journal | Physiology (Bethesda) |
Volume | 33 |
Issue | 1 |
Pagination | 26-38 |
Date Published | 2018 Jan 01 |
ISSN | 1548-9221 |
Keywords | Animals, Extracellular Matrix, Humans, Hypertrophy, Muscle Fibers, Skeletal, Muscle, Skeletal, Satellite Cells, Skeletal Muscle |
Abstract | Recent loss-of-function studies show that satellite cell depletion does not promote sarcopenia or unloading-induced atrophy, and does not prevent regrowth. Although overload-induced muscle fiber hypertrophy is normally associated with satellite cell-mediated myonuclear accretion, hypertrophic adaptation proceeds in the absence of satellite cells in fully grown adult mice, but not in young growing mice. Emerging evidence also indicates that satellite cells play an important role in remodeling the extracellular matrix during hypertrophy. |
DOI | 10.1152/physiol.00019.2017 |
Alternate Journal | Physiology (Bethesda) |
PubMed ID | 29212890 |
PubMed Central ID | PMC5866409 |
Grant List | F32 AR071753 / AR / NIAMS NIH HHS / United States R01 AG049806 / AG / NIA NIH HHS / United States R01 AR060701 / AR / NIAMS NIH HHS / United States |