Title | Macrophage Regulation of Muscle Regrowth From Disuse in Aging. |
Publication Type | Journal Article |
Year of Publication | 2019 |
Authors | Reidy PT, Dupont-Versteegden EE, Drummond MJ |
Journal | Exerc Sport Sci Rev |
Volume | 47 |
Issue | 4 |
Pagination | 246-250 |
Date Published | 2019 10 |
ISSN | 1538-3008 |
Keywords | Aging, Animals, Exercise Therapy, Humans, Immunotherapy, Macrophages, Models, Animal, Muscle, Skeletal, Muscular Atrophy |
Abstract | Skeletal muscle immune cells, such as macrophages, are necessary for proper regrowth after muscle disuse. We suggest that the important role of macrophages concerning muscle regrowth after disuse is divergent compared with young mice (i.e., dysregulated) during the recovery period. Modulation of macrophages may be a promising future therapeutic target to enhance the impaired muscle growth during recovery from disuse in older adults. |
DOI | 10.1249/JES.0000000000000201 |
Alternate Journal | Exerc Sport Sci Rev |
PubMed ID | 31525165 |