Title | Neurocognitive basis of repetition deficits in primary progressive aphasia. |
Publication Type | Journal Article |
Year of Publication | 2019 |
Authors | Lukic S, Mandelli MLuisa, Welch A, Jordan K, Shwe W, Neuhaus J, Miller Z, H Hubbard I, Henry M, Miller BL, Dronkers NF, Gorno-Tempini MLuisa |
Journal | Brain Lang |
Volume | 194 |
Pagination | 35-45 |
Date Published | 2019 07 |
ISSN | 1090-2155 |
Keywords | Aged, Aphasia, Primary Progressive, Cognition, Female, Humans, Male, Memory, Short-Term, Middle Aged, Temporal Lobe |
Abstract | Previous studies indicate that repetition is affected in primary progressive aphasia (PPA), particularly in the logopenic variant, due to limited auditory-verbal short-term memory (avSTM). We tested repetition of phrases varied by length (short, long) and meaning (meaningful, non-meaningful) in 58 participants (22 logopenic, 19 nonfluent, and 17 semantic variants) and 21 healthy controls using a modified Bayles repetition test. We evaluated the relation between cortical thickness and repetition performance and whether sub-scores could discriminate PPA variants. Logopenic participants showed impaired repetition across all phrases, specifically in repeating long phrases and any phrases that were non-meaningful. Nonfluent, semantic, and healthy control participants only had difficulty repeating long, non-meaningful phrases. Poor repetition of long phrases was associated with cortical thinning in left temporo-parietal areas across all variants, highlighting the importance of these areas in avSTM. Finally, Bayles repetition phrases can assist classification in PPA, discriminating logopenic from nonfluent/semantic participants with 89% accuracy. |
DOI | 10.1016/j.bandl.2019.04.003 |
Alternate Journal | Brain Lang |
PubMed ID | 31055171 |
PubMed Central ID | PMC6669076 |
Grant List | P50 AG023501 / AG / NIA NIH HHS / United States U01 AG052943 / AG / NIA NIH HHS / United States R01 NS100440 / NS / NINDS NIH HHS / United States K24 DC015544 / DC / NIDCD NIH HHS / United States R01 DC016345 / DC / NIDCD NIH HHS / United States R03 DC013403 / DC / NIDCD NIH HHS / United States P01 AG019724 / AG / NIA NIH HHS / United States R01 DC016291 / DC / NIDCD NIH HHS / United States R56 NS050915 / NS / NINDS NIH HHS / United States R01 NS050915 / NS / NINDS NIH HHS / United States |