Title | Long-term survival after pneumonectomy for non-small-cell lung cancer. |
Publication Type | Journal Article |
Year of Publication | 2013 |
Authors | Kalathiya RJ, Davenport D, Saha S |
Journal | Asian Cardiovasc Thorac Ann |
Volume | 21 |
Issue | 5 |
Pagination | 574-81 |
Date Published | 2013 Oct |
ISSN | 1816-5370 |
Keywords | Academic Medical Centers, Adult, Aged, Carcinoma, Non-Small-Cell Lung, Chemoradiotherapy, Adjuvant, Chemotherapy, Adjuvant, Female, Humans, Kaplan-Meier Estimate, Kentucky, Lung Neoplasms, Male, Middle Aged, Neoadjuvant Therapy, Pneumonectomy, Radiotherapy, Adjuvant, Registries, Retrospective Studies, Risk Factors, Survivors, Time Factors, Treatment Outcome |
Abstract | OBJECTIVE: to investigate long-term survival in patients who underwent pneumonectomy for non-small-cell lung cancer at the University of Kentucky Medical Center. METHODS: we retrospectively reviewed 100 consecutive pneumonectomy cases from 1998 to 2009 at the University of Kentucky. We were able to obtain follow-up data on 99 of 100 patients. RESULTS: overall 1-, 2-, and 5-year survival was 66%, 48%, and 32%, respectively. The 1-, 2-, and 5- survival for left pneumonectomy was 76%, 55%, and 40%, respectively, compared to 56%, 44%, and 22%, respectively, for right pneumonectomy. The median survival for left pneumonectomy was 2.4 years compared to 1.2 years for right pneumonectomy (p = 0.056). The 5-year survival for patients diagnosed with stage I disease was 34%, compared to 19% for stage II disease, and 38% for stage III disease. The 5-year survival for patients who underwent neoadjuvant therapy was 31% compared to 39% for patients who received adjuvant therapy and 29% for patients who received surgery alone. These results were also not statistically significant. CONCLUSION: neoadjuvant therapy did not adversely affect long-term survival in our study. When compared to left pneumonectomy, right pneumonectomy for non-small-cell lung cancer is associated with adverse postoperative outcomes as well as poorer long-term survival. |
DOI | 10.1177/0218492312467025 |
Alternate Journal | Asian Cardiovasc Thorac Ann |
PubMed ID | 24570560 |