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Local In Vivo Measures of Muscle Lipid and Oxygen Consumption Change in Response to Combined Vitamin D Repletion and Aerobic Training in Older Adults.

TitleLocal In Vivo Measures of Muscle Lipid and Oxygen Consumption Change in Response to Combined Vitamin D Repletion and Aerobic Training in Older Adults.
Publication TypeJournal Article
Year of Publication2019
AuthorsD Thomas T, Schnell DM, Redzic M, Zhao M, Abraha H, Jones D, Brim H, Yu G
JournalNutrients
Volume11
Issue4
Date Published2019 Apr 25
ISSN2072-6643
KeywordsAged, Dietary Supplements, Exercise, Female, Humans, Lipid Metabolism, Male, Middle Aged, Muscle, Skeletal, Oxygen Consumption, Vitamin D
Abstract

Intramyocellular (IMCL), extramyocellular lipid (EMCL), and vitamin D deficiency are associated with muscle metabolic dysfunction. This study compared the change in [IMCL]:[EMCL] following the combined treatment of vitamin D and aerobic training (DAT) compared with vitamin D (D), aerobic training (AT), and control (CTL). Male and female subjects aged 60-80 years with a BMI ranging from 18.5-34.9 and vitamin D status of ≤32 ng/mL (25(OH)D) were recruited to randomized, prospective clinical trial double-blinded for supplement with a 2 × 2 factorial design. Cholecalciferol (Vitamin D) (10,000 IU × 5 days/week) or placebo was provided for 13 weeks and treadmill aerobic training during week 13. Gastrocnemius IMCL and EMCL were measured with magnetic resonance spectroscopy (MRS) and MRI. Hybrid near-infrared diffuse correlation spectroscopy measured hemodynamics. Group differences in IMCL were observed when controlling for baseline IMCL ( = 0.049). DAT was the only group to reduce IMCL from baseline, while a mean increase was observed in all other groups combined ( = 0.008). IMCL reduction and the corresponding increase in rVO at study end ( = 0.011) were unique to DAT. Vitamin D, when combined with exercise, may potentiate the metabolic benefits of exercise by reducing IMCL and increasing tissue-level VO in healthy, older adults.

DOI10.3390/nu11040930
Alternate JournalNutrients
PubMed ID31027191
PubMed Central IDPMC6521174
Grant ListR21AG046762 / NH / NIH HHS / United States
T32 DK007778 / DK / NIDDK NIH HHS / United States
P20 GM121327 / GM / NIGMS NIH HHS / United States
1P20GM121327-01 / NH / NIH HHS / United States
UL1TR001998 / NH / NIH HHS / United States
P30 CA177558 / CA / NCI NIH HHS / United States
T32DK007778-16 / NH / NIH HHS / United States